Temporal associations between sleep slow oscillations, spindles and ripples

Oyanedel, Carlos N.; Durán, Ernesto; Niethard, Niels; Inostroza, Marion; Born, Jan

doi:10.1111/ejn.14906

Cited by 48 publications

(49 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to previous observations in dHPC (Maingret et al, 2016; Molle et al, 2006; Oyanedel et al, 2020; Peyrache et al, 2011; Peyrache et al, 2009; Sirota et al, 2003), vHPC SWR occurrences were moderately increased around UP–DOWN transitions (reached maxima 105 ± 88 ms prior to delta peaks in post-cond. NREM, n= 14 rats; Figure 4I).…”

Section: Resultssupporting

confidence: 89%

De-novointer-regional coactivations of pre-configured local ensembles support memory

Miyawaki

Mizuseki

2021

Preprint

View full text Add to dashboard Cite

Neuronal ensembles in the amygdala, ventral hippocampus, and prefrontal cortex are involved in fear memory; however, how the inter-regional ensemble interactions support memory remains elusive. Using multi-regional large-scale electrophysiology in the aforementioned structures of fear-conditioned rats, we demonstrated that local ensembles activated during fear memory acquisition were inter-regionally coactivated during subsequent sleep, which relied on brief bouts of fast network oscillations. During memory retrieval, coactivations reappeared, accompanying fast oscillations. Ensembles contributing to inter-regional coactivation were configured prior to memory acquisition in the amygdala and prefrontal cortex but developed through experience in the hippocampus. Our observation suggests that elements of a given memory are instantly encoded within various brain regions in a pre-configured manner, whereas hippocampal ensembles and the network for inter-regional integration of the distributed information develop in an experience-dependent manner to form a new memory, which is consistent with hippocampal memory index hypothesis.

show abstract

Section: Resultssupporting

confidence: 89%

De-novointer-regional coactivations of pre-configured local ensembles support memory

Miyawaki

Mizuseki

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Thus, the positive and subsequent negative threshold crossing represented the onset and end of a spindle event, respectively. Previous studies showed that with this criteria larger spindle events are identified that typically occur in parallel in both hemispheres (e.g., Oyanedel et al, 2020).…”

Section: Detection Of Sleep Slow Oscillations and Spindlesmentioning

confidence: 99%

Cell-Type-Specific Dynamics of Calcium Activity in Cortical Circuits over the Course of Slow-Wave Sleep and Rapid Eye Movement Sleep

2021

Self Cite

View full text Add to dashboard Cite

Sleep shapes cortical network activity, fostering global homeostatic down-regulation of excitability while maintaining or even up-regulating excitability in selected networks in a manner that supports memory consolidation. Here we used two-photon calcium imaging of cortical layer 2/3 neurons in sleeping male mice to examine how these seemingly opposing dynamics are balanced in cortical networks. During slow-wave sleep (SWS) episodes, mean calcium activity of excitatory pyramidal (Pyr) cells decreased. Simultaneously, however, variance in Pyr population calcium activity increased, contradicting the notion of a homogenous down-regulation of network activity. Indeed, we identified a subpopulation of Pyr cells distinctly up-regulating calcium activity during SWS, which were highly active during sleep spindles known to support mnemonic processing. REM episodes following SWS were associated with a general down-regulation of Pyr cells -including the subpopulation of Pyr cells active during spindles -which persisted into following stages of sleep and wakefulness. Parvalbumin-positive inhibitory interneurons (PV-In) showed an increase in calcium activity during SWS episodes, while activity remained unchanged during REM sleep episodes. This supports the view that down-regulation of Pyr calcium activity during SWS results from increased somatic inhibition via PV-In, whereas down-regulation during REM sleep is achieved independently of such inhibitory activity. Overall, our findings show that SWS enables up-regulation of select cortical circuits (likely those which were involved in mnemonic processing) through a spindle-related process, whereas REM sleep mediates general down-regulation, possibly through synaptic renormalization. Significance Sleep is thought to globally down-regulate cortical excitability and, concurrently, to upregulate synaptic connections in neuron ensembles with newly encoded memory, with upregulation representing a function of sleep spindles. Using in-vivo two-photon calcium imaging in combination with surface EEG recordings, we classified cells based on their calcium activity during sleep spindles. Spindle-active pyramidal cells persistently increased calcium activity during slow wave sleep (SWS) episodes while spindle-inactive cells decreased calcium activity. Subsequent rapid-eye movement (REM) sleep episodes profoundly reduced calcium activity in both cell clusters. Results indicate that SWS allows for a spindle-related differential upregulation of ensembles whereas REM sleep functions to globally down-regulate networks.

show abstract

“…Slow waves (SWs) are the predominant cortical rhythm during nonrapid eye movement sleep and anesthesia ( 1 , 2 ). Since they were first characterized three decades ago, SWs have been linked to a variety of brain functions, including memory consolidation ( 3 – 6 ), homeostatic synaptic plasticity ( 7 ), and grouping of other oscillatory events ( 8 – 10 ). Macroscopic recordings (scalp electroencephalogram [EEG]) have revealed that spontaneous global SWs occur approximately once per second (∼1 Hz) and propagate in a stereotypical front-to-back topography through the entire cortex ( 11 ).…”

mentioning

confidence: 99%

Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally

Rosenthal

Raut

Bowen

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Slow waves (SWs) are globally propagating, low-frequency (0.5- to 4-Hz) oscillations that are prominent during sleep and anesthesia. SWs are essential to neural plasticity and memory. However, much remains unknown about the mechanisms coordinating SW propagation at the macroscale. To assess SWs in the context of macroscale networks, we recorded cortical activity in awake and ketamine/xylazine-anesthetized mice using widefield optical imaging with fluorescent calcium indicator GCaMP6f. We demonstrate that unilateral somatosensory stimulation evokes bilateral waves that travel across the cortex with state-dependent trajectories. Under anesthesia, we observe that rhythmic stimuli elicit globally resonant, front-to-back propagating SWs. Finally, photothrombotic lesions of S1 show that somatosensory-evoked global SWs depend on bilateral recruitment of homotopic primary somatosensory cortices. Specifically, unilateral lesions of S1 disrupt somatosensory-evoked global SW initiation from either hemisphere, while spontaneous SWs are largely unchanged. These results show that evoked SWs may be triggered by bilateral activation of specific, homotopically connected cortical networks.

show abstract

Temporal associations between sleep slow oscillations, spindles and ripples

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 48 publications

References 70 publications

De-novointer-regional coactivations of pre-configured local ensembles support memory

De-novointer-regional coactivations of pre-configured local ensembles support memory

Cell-Type-Specific Dynamics of Calcium Activity in Cortical Circuits over the Course of Slow-Wave Sleep and Rapid Eye Movement Sleep

Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally

Contact Info

Product

Resources

About