Temporal Aspects of the Regulation of Corpus Luteum Function by Luteinizing Hormone, Prolactin and Placental Luteotrophin During the First Half of Pregnancy in the Rat<sup>1</sup><sup>2</sup>

Morishige, Walter K.; Rothchild, I.

doi:10.1210/endo-95-1-260

Cited by 223 publications

(78 citation statements)

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“…Recoveries from the effects were observed beginning in Week 3 and there were no detrimental effects detectable in Week 4. The decrease in the number of corpora lutea at 30 and 40 mg/kg in Week 1 might be related to the early embryonic deaths observed in this study (Morishige and Rothchild, 1974).…”

Section: Fertilitymentioning

confidence: 59%

A Time-Course Characterization of Male Reproductive Toxicity in Rats Treated With Methyl Methanesulphonate (Mms)

et al. 2005

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-Methyl methanesulphonate (MMS), a potent alkylating agent and testicular toxicant, was orally administered to rats for 5 days at doses of 20, 30, and 40 mg/kg. During the recovery period of 5 weeks, males were evaluated for multiple endpoints such as organ weights, fertility, and sperm parameters. The 5-week recovery periods are designated as follows: Day 1 (1 day after final treatment); Week 1, Week 2, Week 3, Week 4, and Week 5 (first, second, third, fourth, and fifth week after final treatment). A clear time-course of dominant lethals was observed. The peak severities of the dominant lethals were observed in Week 2. It was judged that the most sensitive cellular targets for the dominant lethals are late spermatids. Sperm examination revealed a clear time-course and dose-dependent changes in the frequency of sperm morphological abnormalities. The peak severities of the sperm morphological alterations in cauda epididymis were observed in Week 4. Sensitive cellular stages for the induction of sperm morphological abnormalities were judged to be late spermatocytes and early spermatids. The most frequently observed type of morphologically abnormal spermatozoa was tailless sperm, followed by no-hook head sperm. Although the initial cause for both sperm morphological alterations and dominant lethals was suggested to be genetic insult to the germ cells, there were no obvious relationships observed between these two findings.

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Section: Fertilitymentioning

confidence: 59%

A Time-Course Characterization of Male Reproductive Toxicity in Rats Treated With Methyl Methanesulphonate (Mms)

et al. 2005

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“…The finding that CL were heavier in unilaterally ovariectomized rats suggests that they were subjected to a greater luteotrophic stimulus. The actual stimulus for this, and indeed for the normal increase in progesterone levels after Day 10, is uncertain but it occurs at a time of increasing dominance of placental over pituitary luteotrophins (Morishige & Rothchild, 1974). The unilaterally ovariectomized rats exhibited placental hypertrophy which has been observed in a number of experimental situations likely to have increased the demand for luteotrophins (Csapo & Csapo, 1973;Petropoulos, 1973 (Meyer & Bruce, 1979b) but this may have been due to 2 of the 5 rats in the present study having only 3 CL.…”

Section: Plasma Progesterone Concentrationsmentioning

confidence: 58%

Rate of ovarian progesterone secretion and peripheral plasma progesterone levels in unilaterally ovariectomized, pregnant rats

Meyer¹,

Bruce²

1982

Reproduction

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“…The rat has a very efficient reproductive system, which utilizes PRL as a luteotrophic factor [32]. The rat has no luteal phase during its normal ovulatory cycle and ovulates at 4-5 day intervals if the female does not have a chance to mate with a male.…”

Section: Discussionmentioning

confidence: 99%

A cDNA Encoding a New Member of the Rat Placental Lactogen Family, PL-I mosaic (PL-Im).

et al. 1994

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Abstract. We have isolated a cDNA encoding a novel placental lactogen (PL), PL-I mosaic (PL-Im), by screening the cDNA library in ,ZAP of the mid-pregnant (day 12) rat placenta. The cDNA comprised an open reading frame of 687 by encoding 229 amino acids, in which there were two putative Nglycosylation sites. Northern blot analysis showed that PL-Im mRNA was expressed specifically during mid-pregnancy (days 10 and 12) in the rat placenta. The cDNA was highly homologous with those of other rat PL family members; in particular, the homology among PL-Im, PL-I (mid-pregnancy-specific) and PL-Iv (late-pregnancy-specific) was over 90%. Interestingly, the nucleotide sequence of PL-Im cDNA was a mosaic of PL-I and PL-Iv and it did not possess its own particular sequence. As the genomic pattern determined using Southern blot analysis of PL-Im was distinct from that of PL-I and PLIv, the encoded area of PL-Im appears to be independent of those of PL-I and PL-Iv on the gene. In the dendrogram of the rat PL family constructed on the basis of the nucleotide sequence homologies, PL-Im was located between PL-Iv and PL-I in the process of molecular evolution. Therefore, PL-Im has a unique cDNA structure and may be a principal factor in the molecular evolution of PLs.

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Temporal Aspects of the Regulation of Corpus Luteum Function by Luteinizing Hormone, Prolactin and Placental Luteotrophin During the First Half of Pregnancy in the Rat¹²

Cited by 223 publications

References 0 publications

A Time-Course Characterization of Male Reproductive Toxicity in Rats Treated With Methyl Methanesulphonate (Mms)

A Time-Course Characterization of Male Reproductive Toxicity in Rats Treated With Methyl Methanesulphonate (Mms)

Rate of ovarian progesterone secretion and peripheral plasma progesterone levels in unilaterally ovariectomized, pregnant rats

A cDNA Encoding a New Member of the Rat Placental Lactogen Family, PL-I mosaic (PL-Im).

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Temporal Aspects of the Regulation of Corpus Luteum Function by Luteinizing Hormone, Prolactin and Placental Luteotrophin During the First Half of Pregnancy in the Rat12

Cited by 223 publications

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A Time-Course Characterization of Male Reproductive Toxicity in Rats Treated With Methyl Methanesulphonate (Mms)

A Time-Course Characterization of Male Reproductive Toxicity in Rats Treated With Methyl Methanesulphonate (Mms)

Rate of ovarian progesterone secretion and peripheral plasma progesterone levels in unilaterally ovariectomized, pregnant rats

A cDNA Encoding a New Member of the Rat Placental Lactogen Family, PL-I mosaic (PL-Im).

Contact Info

Product

Resources

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Temporal Aspects of the Regulation of Corpus Luteum Function by Luteinizing Hormone, Prolactin and Placental Luteotrophin During the First Half of Pregnancy in the Rat¹²