Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma

Boffetta, Paolo; Goldfarb, David G.; Zeig‐Owens, Rachel; Kristjansson, Dana; Li, Jiehui; Brackbill, Robert M.; Farfel, Mark R.; Cone, James E.; Yung, Janette; Kahn, Amy R.; Qiao, Baozhen; Schymura, Maria J.; Webber, Mayris P.; Prezant, David J.; Dasaro, Christopher R.; Todd, Andrew C.; Hall, Charles B.

doi:10.1016/j.xjidi.2021.100063

Cited by 2 publications

(3 citation statements)

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“…Demonstrating the importance of long‐term follow‐up studies with adequate statistical power, our recent pooled analysis of three cohorts of WTC workers showed that greater intensity of WTC exposure was associated with an increased risk of melanoma, prostate, thyroid, and tonsil cancers 9 . Additionally, two recent analyses of melanoma and prostate cancer in WTC responders found significantly shorter latency/induction periods from time of WTC exposure to onset of illness, when compared to previous reports 10,11 . These cancers are characterized as well by disparities by race and ethnicity.…”

Section: Introductionmentioning

confidence: 86%

“…9 Additionally, two recent analyses of melanoma and prostate cancer in WTC responders found significantly shorter latency/induction periods from time of WTC exposure to onset of illness, when compared to previous reports. 10,11 These cancers are characterized as well by disparities by race and ethnicity. In particular, the incidence of prostate cancer is higher in Blacks and that of melanoma and thyroid and oropharyngeal cancer is higher in Whites.…”

Section: Introductionmentioning

confidence: 99%

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Cancer incidence in World Trade Center rescue and recovery workers by race and ethnicity

Khalifeh,

Goldfarb,

Zeig‐Owens

et al. 2023

American J Industrial Med

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IntroductionIt is unclear whether differences in health outcomes by racial and ethnic groups among World Trade Center (WTC) rescue and recovery workers reflect those of the population of New York State (NYS) or show distinct patterns. We assessed cancer incidence in WTC workers by self‐reported race and ethnicity, and compared it to population figures for NYS.MethodsA total of 61,031 WTC workers enrolled between September 11, 2001 and January 10, 2012 were followed to December 31, 2015. To evaluate the association between race/ethnicity and cancer risk, Poisson regression analysis was used to estimate hazard ratios (HR) adjusted for WTC exposure, age, calendar year, sex and, for lung cancer, cigarette smoking.ResultsIn comparison to Whites, Black workers had a higher incidence of prostate cancer (HR = 1.99, 95% CI = 1.69−2.34) and multiple myeloma (HR = 3.57, 95% CI = 1.97−6.45), and a lower incidence of thyroid (HR = 0.41, 95% CI = 0.22−0.78) and colorectal cancer (HR = 0.57; 95% CI = 0.33−0.98). Hispanic workers had a higher incidence of liver cancer (HR = 4.03, 95% CI = 2.23−7.28). Compared with NYS population, White workers had significantly higher incidence of prostate cancer (HR = 1.26, 95% CI = 1.18−1.35) and thyroid cancer (HR = 1.80, 95% CI = 1.55−2.08), while Black workers had significantly higher incidence of prostate cancer (HR = 1.22, 95% CI = 1.05−1.40).ConclusionCancer incidence in WTC workers generally reflects data from the NYS population, but some differences were identified that merit further investigation.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Cancer incidence in World Trade Center rescue and recovery workers by race and ethnicity

Khalifeh,

Goldfarb,

Zeig‐Owens

et al. 2023

American J Industrial Med

Self Cite

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“…In total, 247 incident cases of cutaneous melanoma were observed among White RRWs (the numbers of cases among non‐White RRWs were too small to analyze) 37 . No increase in the incidence of melanoma was detected during 2002 through 2004; however, beginning in 2005, a 34% increased risk was observed compared with the NYS reference population (HR, 1.34; 95% CI, 1.18‐1.52).…”

Section: Published Reports On Wtc‐rrws From the Combined Cohortmentioning

confidence: 99%

Cancer risk among World Trade Center rescue and recovery workers: A review

Boffetta

Hall

Todd

et al. 2022

CA A Cancer J Clinicians

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Twenty years after the September 11th, 2001 terrorist attacks, the association between exposures present at the World Trade Center (WTC) site and the risk of several specific types of cancer has been reported among rescue and recovery workers. The authors' objective was to conduct an updated review of these data. Most studies have found elevated rates of both prostate and thyroid cancers compared with rates in the general population, and some have reported statistically significant differences for the rates of all cancers as well. Studies including a larger combined cohort of WTC-exposed rescue and recovery workers from 3 main cohorts have since replicated findings for these cancers, with additional years of follow-up. Among this combined cohort, although a lower-than-expected standardized incidence ratio for all cancers was observed, WTC exposure was also related to an increased risk of cutaneous melanoma and tonsil cancer. Importantly, another study found that WTCexposed rescue and recovery workers who are enrolled in the federally funded medical monitoring and treatment program experienced improved survival post-cancer diagnosis compared with New York state patients with cancer. On the basis of these combined cohort studies, the full effect of WTC exposure on cancer risk is becoming clearer. Consequently, the authors believe that surveillance of those with WTC exposure should be continued, and in-depth analysis of epidemiologic, molecular, and clinical aspects of specific cancers in these workers should be pursued.

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Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma

Cited by 2 publications

References 55 publications

Cancer incidence in World Trade Center rescue and recovery workers by race and ethnicity

Cancer incidence in World Trade Center rescue and recovery workers by race and ethnicity

Cancer risk among World Trade Center rescue and recovery workers: A review

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