Abstract:BackgroundInducible nitric oxide synthase (iNOS) is associated with inflammation and osteoclastic differentiation in periodontal disease. This study was conducted to compare the time‐dependent variation in iNOS production between the gingiva and other periodontal tissues and to explore the potential association with C‐reactive protein (CRP) in early periodontal disease.MethodsLigature‐induced periodontal disease models (0–14 days) were established in wild‐type and CRP knockout rats. Changes in CRP, iNOS, and a… Show more
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