Temporal and climate characteristics of respiratory syncytial virus bronchiolitis in neonates and children in Sousse, Tunisia, during a 13-year surveillance

Brini, Inès; Bhiri, S; Ijaz, Munazza; Bouguila, Jihéne; Nouri-Merchaoui, S.; Boughammoura, L.; Sboui, H.; Hannachi, Naila; Boukadida, Jalel

doi:10.1007/s11356-018-3922-x

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…It is known that cold temperatures facilitate the survival and spread of viruses more easily [ 22 ]. Tunisia is characterized by high humidity intervals > 60% [ 23 ]. Specific Tunisian climate parameters could explain outbreaks timings and strains identified.…”

Section: Discussionmentioning

confidence: 99%

Severe influenza A in a Tunisian ICU sentinel SARI centre: Epidemiological and clinical features

et al. 2022

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Introduction Influenza A virus infection is a contagious acute respiratory infection which mostly evolves in an epidemic form, less frequently as pandemic outbreaks. It can take a severe clinical form that needs to be managed in intensive care unit (ICU). The aim of this study was to describe the epidemiological and clinical aspects of influenza A, then to determine independent predictive factors of ICU mortality in Abderrahmen Mami hospital, Ariana, Tunisia. Methods It was a single-center study, including all hospitalized patients in intensive care, between November 1st, 2009 and October 31st, 2019, with influenza A virus infection. We recorded demographic, clinical and biological data, evolving features; then multivariate analysis of the predictive factors of ICU mortality was realized. Results During the study period (10 consecutive seasons), 120 patients having severe Influenza A were admitted (Proportion = 2.5%) from all hospitalized patients, with a median age of 48 years and a gender-ratio of 1.14. Among women, 14 were pregnant. Only 7 patients (5.8%) have had seasonal flu vaccine during the year before ICU admission. The median values of the Simplified Acute Physiology Score II, Acute Physiologic and Chronic Health Evaluation II and Sepsis-related Organ Failure Assessment were respectively 26, 10 and 3. Virus strains identified with polymerase chain reaction were H1N1 pdm09 (84.2%) and H3N2 (15.8%). Antiviral therapy was prescribed in 88 (73.3%) patients. A co-infection was recorded in 19 cases: bacterial (n = 17) and aspergillaire (n = 2). An acute respiratory distress syndrome (ARDS) was diagnosed in 82 patients. Non-invasive ventilation (NIV) was conducted for 72 (60%) patients with success in 34 cases. Endotracheal intubation was performed in 59 patients with median duration of invasive mechanical ventilation 8 [3.25–13] days. The most frequent complications were acute kidney injury (n = 50, 41.7%), shock (n = 48, 40%), hospital-acquired infections (n = 46, 38.8%) and thromboembolic events (n = 19, 15.8%). The overall ICU mortality rate was of 31.7% (deceased n = 38). Independent predictive factors of ICU mortality identified were: age above 56 years (OR = 7.417; IC95% [1.474–37.317]; p = 0.015), PaO2/FiO2 ≤ 95 mmHg (OR = 9.078; IC95% [1.636–50.363]; p = 0.012) and lymphocytes count ≤ 1.325 109/L (OR = 10.199; IC95% [1.550–67.101]; p = 0.016). Conclusion Influenza A in ICU is not uncommon, even in A(H1N1) dominant seasons; its management is highly demanding. It is responsible for considerable morbi-mortality especially in elderly patients.

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Section: Discussionmentioning

confidence: 99%

Severe influenza A in a Tunisian ICU sentinel SARI centre: Epidemiological and clinical features

et al. 2022

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“…In contrast, the Edendale site is in a sub-tropical climatic zone. Several studies have explored climatic relationships to RSV seasonality but none have described an association between climate and severity of illness [24][25][26][27] . Similarly, studies have explored air pollution with respect to seasonality and epidemics of RSV but we did not have data on air pollution [28] .…”

Section: Risk Factors For Rsv-associated Sari Among Children Aged <5 ...mentioning

confidence: 99%

Risk factors for severe respiratory syncytial virus-associated respiratory tract infection in a high HIV prevalence setting, prior to the SARS-CoV-2 pandemic, South Africa, 2012 – 2018

Moyes,

Tempia,

Walaza

et al. 2024

Preprint

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Background Identifying risk factors for respiratory syncytial virus (RSV)–associated severe acute respiratory illness (SARI) will assist with targeting vaccine interventions. Methods Using surveillance data from South Africa (2012-2018). We compared the characteristics of individuals with RSV-associated ILI (reference group) to those with RSV-associated SARI to describe factors associated with SARI using a multivariable analysis. Results RSV was detected in 6% (483/7792) of ILI cases and 15% (844/5672) of SARI cases. Factors associated with SARI in children included age <2 months, compared to age 2–4 years (adjusted odds ratio (aOR) 54.4; 95% confidence interval (CI) 23.5–125.8), malnutrition (aOR 1.9; 95% CI 1.2–3.2), prematurity (aOR 2.4; 95% CI 1.3–4.6) and living with HIV (LWH) (aOR 22.5; 95% CI 2.9–174.3). In individuals ≥5 years, factors associated with SARI included age ≥65 years compared to age 5–24 years (aOR 10.7; 95% CI 1.1–107.5), symptom duration ≥5 days (aOR 2.7; 95% CI 1.1–6.3), underlying illness (aOR 2.7; 95% CI 1.5–26.1) and LWH (aOR 16.8, 95% CI: 4.8–58.2). Conclusion Individuals at the extremes of age and those with identified risk factors a might benefit most from RSV prevention interventions.

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“…After all, the impact of climatic factors (including temperature, precipitation and humidity) on viral circulation and in particular for respiratory syncytial virus (RSV) bronchiolitis have been statistically analysed for some time to help determine the optimal timing of appropriate strategies to prevent RSV outbreaks, taking into account the specific climatic parameters of a given area [ 117 ].…”

Section: Sars-cov-2 and Pollutionmentioning

confidence: 99%

Air Pollution and COVID-19: A Possible Dangerous Synergy for Male Fertility

Montano

Donato

Bianco

et al. 2021

IJERPH

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Several studies indicate that semen quality has strongly declined in the last decades worldwide. Air pollution represents a significant co-factor with the COVID-19 impact and has negative effects on the male reproductive system, through pro-oxidant, inflammatory and immune-dysregulating mechanisms. It has recently been reported that chronic exposure to PM2.5 causes overexpression of the alveolar ACE2 receptor, the entry route of SARS-CoV-2 into the organism shared by the lungs and testis where expression is highest in the body. In the testis, the ACE2/Ang-(1–7)/MasR pathway plays an important role in the regulation of spermatogenesis and an indirect mechanism of testicular damage could be due to the blockade of the ACE2 receptor by SARS-CoV-2. This prevents the conversion of specific angiotensins, and their excess causes inflammation with the overproduction of cytokines. PM2.5-induced overexpression of the alveolar ACE2 receptor, in turn, could increase local viral load in patients exposed to pollutants, producing ACE2 receptor depletion and compromising host defenses. By presenting an overall view of epidemiological data and molecular mechanisms, this manuscript aims to interpret the possible synergistic effects of both air pollution and COVID-19 on male reproductive function, warning that the spread of SARS-CoV-2 in the fertile years may represent a significant threat to global reproductive health. All of this should be of great concern, especially for men of the age of maximum reproductive capacity, and an important topic of debate for policy makers. Altered environmental conditions, together with the direct and indirect short- and long-term effects of viral infection could cause a worsening of semen quality with important consequences for male fertility, especially in those areas with higher environmental impact.

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Temporal and climate characteristics of respiratory syncytial virus bronchiolitis in neonates and children in Sousse, Tunisia, during a 13-year surveillance

Cited by 6 publications

References 36 publications

Severe influenza A in a Tunisian ICU sentinel SARI centre: Epidemiological and clinical features

Severe influenza A in a Tunisian ICU sentinel SARI centre: Epidemiological and clinical features

Risk factors for severe respiratory syncytial virus-associated respiratory tract infection in a high HIV prevalence setting, prior to the SARS-CoV-2 pandemic, South Africa, 2012 – 2018

Air Pollution and COVID-19: A Possible Dangerous Synergy for Male Fertility

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