Templating Route for Mesostructured Calcium Phosphates with Carboxylic Acid- and Amine-Type Surfactants

Abstract

Mesostructured calcium phosphates constructed by ionic frameworks were synthesized using carboxylic acid- and amine-type surfactants in mixed solvent systems of ethanol and water. A lamellar mesostructured calcium phosphate was prepared using palmitic acid as an anionic surfactant, as in the case using n-alkylamines. A wormhole-like mesostructured calcium phosphate can be obtained using dicarboxyl N-lauroyl- l-glutamic acid, whose headgroup is larger than that of palmitic acid. Similar mesostructured product was obtained using 4-dodecyldiethylenetriamine with a large headgroup containing two primary amine groups. Interactions of carboxyl and primary amino groups in the surfactant molecules with inorganic species are quite important for the formation of mesostructured calcium phosphates. The Ca/P molar ratio of mesostructured calcium phosphates was strongly affected by the molecular structure of surfactants containing carboxyl and primary amino groups. Ca-rich materials can be obtained using carboxylic acid-type surfactants (Ca/P approximately 1.7) rather than amine-type surfactants (Ca/P approximately 1.0).

Mesoporous calcium phosphate using casein as a template: Application to bovine serum albumin sorption

“…In general, ordered mesoporous pore arrangement and narrow pore distribution are not observed in conventional calcium phosphate [25]. Some studies demonstrated that nanosized Hap has a high surface functional properties, resulting in better cell adhesion and cell-matrix interactions [2,24].…”

Smart Soft‐Templating Synthesis of Hollow Mesoporous Bioactive Glass Spheres

“…The formation rate of HA is influenced by the content of Ca 2 + ions and phosphorus. [28,29] Recently,s everalm esoporousc alcium phosphates have been reported, [30][31][32] in which ap hase transformation to the most thermodynamically stable HA is promoted. [29,33,34] The formation of HA crystal was confirmed by XRD measurements.…”

Block-copolymer-assisted synthesis of hydroxyapatite nanoparticles with high surface area and uniform size

“…Ye et al prepared hollow HA nanospheres and nanotubes using polymeric micelles of P123 and Tween-60 as templates [11]. Mesoporous HP [12] and ordered mesostructured calcium phosphate [13][14][15][16] were also synthesized using surfactants as structure-directing agents.…”