Templated growth of calcium phosphate on tyrosine derived microtubules and their biocompatibility

Spear, Rose L.; Tamayev, Robert; Fath, Karl R.; Banerjee, Ipsita A.

doi:10.1016/j.colsurfb.2007.05.025

Cited by 21 publications

(12 citation statements)

References 57 publications

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“…These needle-like structures are prominently visible in the adhesion variation and are typically measured to be 200–600 nm in length and 20–25 nm in height as can be concluded from AFM cross-section images (Figure ). We suggest that these needle-like structures are composed of PP-Tyr structures which have grown to larger sizes as compared to the nanoscale features seen on the PP-Tyr film and reported in the literature. , These studies suggest the formation of tubular structures based upon tyrosine is possible under vacuum deposition conditions and a similar phenomenon may be occurring in our plasma deposition process . These structures are likely seen on the surface of the film as sublimation will continue for a short time after the heating crucible and plasma are switched off while the crucible cools.…”

Section: Resultssupporting

confidence: 65%

Plasma-Enhanced Copolymerization of Amino Acid and Synthetic Monomers

et al. 2012

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In this paper we report the use of plasma-enhanced chemical vapor deposition (PECVD) for the simultaneous deposition and copolymerization of an amino acid with other organic and inorganic monomers. We investigate the fundamental effects of plasma-enhanced copolymerization on different material chemistries in stable ultrathin coatings of mixed composition with an amino acid component. This study serves to determine the feasibility of a direct, facile method for integrating biocompatible/active materials into robust polymerized coatings with the ability to plasma copolymerize a biological molecule (L-tyrosine) with different synthetic materials in a dry, one-step process to form ultrathin coatings of mixed composition. This process may lead to a method of interfacing biologic systems with synthetic materials as a way to enhance the biomaterial-tissue interface and preserve biological activity within composite films.

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Section: Resultssupporting

confidence: 65%

Plasma-Enhanced Copolymerization of Amino Acid and Synthetic Monomers

et al. 2012

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“…Individual stock solutions (8 mM) of the bis(N-alpha-amido-threonine)-1,3 propane dicarboxylate monomers were prepared in buffer solutions 24 …”

Section: Self-assemblymentioning

confidence: 99%

“…Nanotubes and microtubes self-assembled from peptide bolaamphiphiles (amino acid head groups covalently bound via hydrocarbon chain), exhibit several different properties that make them promising biomaterial candidates, including facile self-assembly in aqueous solutions and adaptability to functionalization for increased biocompatibility (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The peptide head groups can be readily modified in order to manipulate and potentially alter the properties of the self-assembled micro and nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly and Growth of Smart Cell‐Adhesive Mucin‐Bound Microtubes

et al. 2009

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%Microtubular structures were self-assembled in aqueous media from a newly synthesized bolaamphiphile, bis(N-a-amido-threonine)-1,3-propane dicarboxylate. The self-assembly process was examined at varying pH. The formed microtubes were then functionalized with the highly glycosylated protein mucin. In nature, the O-linked saccharides of mucin are generally associated with Thr or Ser residues of protein scaffolds. In this work, peptide microtubes with threonine functionality were prepared synthetically in order to enhance the affinity of the microtubes toward mucin, thus mimicking natural proteins. After binding the mucin to the microtubes, we investigated the biocompatibility of those materials by conducting in vitro cell attachment, cell proliferation, and cytotoxicity studies using normal rat kidney (NRK) cells. The studies revealed that the biomaterials were nontoxic, biocompatible, and showed significant adhesion to the cells. It is well known that natural mucins may degrade into their motifs; however, upon binding to the surface of microtubes, their stability may be increased. Because mucin is one of the major components of mucoadhesion, and various types of mucins are ubiquitous in human tissues, such mucin-bound microtubes may potentially be used as mucoadhesive materials for targeted drug delivery and improve the localization of drugs.

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“…Peptide nanotubes and microtubes are a relatively new class of self assembled materials that have attracted a lot of interest for drug delivery applications due to their biocompatibility as well as ability to be functionalized. 111,112 Recently, Banerjee et al 113 have demonstrated the ability of the microtubes formed of bolaamphiphile, bis(N-a-amido-threonine)-1,5-pentane dicarboxylate as drug release vehicles for ellagic acid (EA, a plant polyphenol known for its wide-range of health benefits). The release of EA from microtubules was found to be both pH and concentration dependent and the EA-loaded microtubules were found to be biocompatible with mammalian normal rat kidney cells.…”

Section: Tubulesmentioning

confidence: 99%

Self assembled materials: design strategies and drug delivery perspectives

Verma

Hassan

2013

Phys. Chem. Chem. Phys.

122

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Self assembly of small molecules in complex supramolecular structures provides a new avenue in the development of materials for drug delivery applications. Owing to the low aqueous solubility of various drugs, an effective delivery system is often required to reach sufficient drug bioavailability and/or to facilitate clinical use. Micelles, amphiphilic gels, vesicles (liposomes), nanodisks, cubosomes, colloidosomes, tubules, microemulsions, lipid particles, polyelectrolyte capsules etc. are some of the intriguing structures formed via self assembly. As well as enabling improved solubilization, such materials can be tuned to offer a range of other advantages, including controlled or stimuli sensitive drug release, protection from drug hydrolysis and chemical or enzymatic degradation, a reduction in toxicity, improvement of drug availability, prevention of RES uptake or selective targeting to organelles etc. Such multiple functionalities can be brought together by self assembly of different functional molecules. This route offers a cost effective means of developing drug delivery carriers tailored to specific needs. Our current understanding of the microstructure evolution of self assembled materials will go a long way towards designing/selecting molecules to create well defined structures. We believe that most of the potential resources mentioned above are untapped and that there is a need to further strengthen research in this area to fully exploit their potential. Selective cross linking of core or shell, stimuli sensitive amphiphiles, prodrug amphiphiles, antibody coupled amphiphiles etc. are only some of the new approaches for the development of effective drug delivery systems via self assembly.

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Templated growth of calcium phosphate on tyrosine derived microtubules and their biocompatibility

Cited by 21 publications

References 57 publications

Plasma-Enhanced Copolymerization of Amino Acid and Synthetic Monomers

Plasma-Enhanced Copolymerization of Amino Acid and Synthetic Monomers

Self‐Assembly and Growth of Smart Cell‐Adhesive Mucin‐Bound Microtubes

Self assembled materials: design strategies and drug delivery perspectives

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