Template Synthesized Molecularly Imprinted Polymer Nanotube Membranes for Chemical Separations

Abstract

In this report, we describe the synthesis of a molecularly imprinted polymer (MIP) nanotube membrane, using a porous anodic alumina oxide (AAO) membrane by surface-initiated atom transfer radical polymerization (ATRP). The use of a MIP nanotube membrane in chemical separations gives the advantage of high affinity and selectivity. Furthermore, because the molecular imprinting technique can be applied to different kinds of target molecules, ranging from small organic molecules to peptides and proteins, such MIP nanotube membranes will considerably broaden the application of nanotube membranes in chemical separations and sensors. This report also shows that the ATRP route is an efficient procedure for the preparation of molecularly imprinted polymers. Furthermore, the ATRP route works well in its formation of MIP nanotubes within a porous AAO membrane. The controllable nature of ATRP allows the growth of a MIP nanotube with uniform pores and adjustable thickness. Thus, using the same route, it is possible to tailor the synthesis of MIP nanotube membranes with either thicker MIP nanotubes for capacity improvement or thinner nanotubes for efficiency improvement.

Molecularly imprinted polymers by reversible addition–fragmentation chain transfer precipitation polymerization for preconcentration of atrazine in food matrices

“…The main including reversible addition-fragmentation chain transfer (RAFT) polymerization, metal-catalyzed atom transfer radical polymerization (ATRP), nitroxide-mediate polymerization (NMP) and iniferter, due to their intrinsic advantages over conventional free radical polymerization, such as producing well-defined polymers with predictable molecular, low polydispersity, controlled composition and functionality [17]. RAFT polymerization, the ideal candidate for CLRP has also been applied for MIPs preparation because of its versatility and simplicity.…”

Plastic antibody for DNA damage: fluorescent imaging of BPDE–dG adducts in genomic DNA

“…24,[31][32][33] Atom transfer radical polymerization (ATRP), a novel living/ controlled radical polymerization technique, has been successfully used for the fabrication of nanoscaled MIPs with ordered structures and improved binding properties. 33,35,36 ATRP allows polymers to be grown in a controlled, piece-by-piece fashion, and enables researchers to create a wide range of polymers with site specic tailored functionalities for various applications. [34][35][36][37] The aim of this study is to fabricate a high-affinity plastic antibody for benzo[a]pyrene diol epoxide (BPDE)-DNA adducts, a DNA damage product produced by benzo[a]pyrene (B[a]P) exposure, using an initiator for continuous activator regeneration-atom transfer radical polymerization (ICAR-ATRP).…”

“…33,35,36 ATRP allows polymers to be grown in a controlled, piece-by-piece fashion, and enables researchers to create a wide range of polymers with site specic tailored functionalities for various applications. [34][35][36][37] The aim of this study is to fabricate a high-affinity plastic antibody for benzo[a]pyrene diol epoxide (BPDE)-DNA adducts, a DNA damage product produced by benzo[a]pyrene (B[a]P) exposure, using an initiator for continuous activator regeneration-atom transfer radical polymerization (ICAR-ATRP). B[a]P is a carcinogenic polycyclic aromatic hydrocarbon that can be metabolized in vivo into a reactive metabolite BPDE.…”

Quartz crystal microbalance study of the kinetics of surface initiated polymerization

“…For example, polymer brushes via SIP rendered stability to dispersed nano-particles and colloids [4][5][6][7][8][9] , minimized nonspecific protein adsorption, improved biocompatibility [10][11][12][13][14][15] , and acted as matrix for biosensors [16][17][18] and separation applications [19][20][21][22] . SIP also opened new ways for nano/micro-fabrication [23][24][25][26][27][28] , altered fluid behavior in nano/micro-fluidic devices [29][30][31] , and was found in other exotic applications [32][33][34][35] .…”