Template Synthesis of Novel 14-Membered Tetraazamacrocyclic Transition Metal Complexes: Dna Cleavage and Antimicrobial Studies

Abstract

A new series of 14 membered tetraazamacrocyclic complexes of type [ML]X 2 , where M=Ni(II), Co(II), Cu(II), Zn(II), Hg(II), VO(IV), Cd(II) and Mn(II); X 2 = 2Cl-; SO 4 2-, have been synthesized by incorporating an N 4 donor site via. the template condensation of o-phenylenediamine, formaldehyde, p-anisidine and metal salt. The structural features of the complexes have been confirmed by spectral and analytical data. From the data, a square-planar geometry around the central metal ion has been suggested except VO(IV) complex which has square-pyramidal geometry. The antimicrobial screening data show good results. From the nuclease activity of the above metal complexes, it is inferred that only the copper and nickel complexes cleave DNA through redox chemistry.

Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde

“…Also, at 3483 cm -1 , the band was attributed to ]OH in the ligand (H-MFMAQ) which disappeared in its metal complexes indicating deprotonation of the OH moiety during coordination [17]. The new bands at 543-552, 433-438, and 412-416 cm −1 were assigned to M-O (carbonyl), M-O (phenol), M-N (azomethine) and (M-Cl) in the metal complexes spectra were observed [15,17]. The IR results showed that the metal was harmonized through one nitrogen atom (azomethine group) and three oxygen atoms (deprotonated hydroxyl group, carbonyl group, and furan ring) besides chlorine atoms.…”

“…The reduction of is caused by complex formation by the delocalization of the d-electron cloud on the ligand, which in turn causes the covalent bond formation. The data shows the Co(II) complex has covalent character in the metal ligand " " bond [15]. H-MFMAQ 3483br -1712m 1637m 1618m ---1 --1693w 1621m 1600m 543m 433w 416m 2 --1698m 1622m 1600w 548s 434w 412w 3 -3320br 1695s 1622m 1605w 552m 438m 414m 4 -3300r 1693m 1625sh 1602m 547m 434m 41 m 5 -3320br 1697m 1624m 1605m 552m 437m 413m 6 -3300r 1696m 1625m 1604m 549m 435m 414m 7 -3318br 1698m 1623m 1603m 547m 438m 415m sh: sharp, m: medium, br: broad, s: small, and w: weak.…”

“…obtained by utilizing the correlation = (complex)/ (free ion), where (free ion) for Ni(II) is 1041 cm -1 [15]. The value of lies at 0.27.…”

“…The Zn(II) complex [Zn(MFMAQ)Cl(H 2 O)]⋅2.5H 2 O is diamagnetic as predictable and its geometry is most likely octahedral likewise Mn(II), Cu(II), Ni(II), and Co(II) complexes of H-MFMAQ ligand [15].…”

Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

“…The bands appeared in the region of 450-434 cm −1 were assigned to ] (M-N) for complexes 1-4, indicating that the imine and pyrimidine nitrogen atoms are involved coordination with central metal ions [19]. The bands observed in the region of 497-502 cm −1 were assigned to ] (M-O) for complexes 1-4, indicating that the phenolic oxygen atom was involved in coordination with central metal ions [20].…”