Template Polymerization

Połówiński, S.

doi:10.1002/0471440264.pst465

Cited by 18 publications

(25 citation statements)

References 75 publications

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“…This encoding makes such polymers "tuned" on the specific pattern and thus predetermines the ability of the polymer to recognize the surface pattern. 13 The studies of heteropolymer adsorption on chemically heterogeneous surfaces have been performed with analytical, numerical, and experimental techniques. [14][15][16][17][18][19] Chakraborty and co-workers reported on the theoretical and simulation studies regarding the recognition ability of random heteropolymers interacting with multifunctional surfaces.…”

Section: Introductionmentioning

confidence: 99%

Recognition of complex patterned substrates by heteropolymer chains consisting of multiple monomer types

Kriksin

Khalatur

Khokhlov

2006

The Journal of Chemical Physics

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We propose a statistical mechanical model of surface pattern recognition by heteropolymers with quenched monomer sequence distribution. The chemically heterogeneous pattern consists of different adsorption sites specifically distributed on a surface. The heteropolymer sequence is complementary with respect to the pattern. The concepts of recognition probability and recognition temperature are introduced. The algorithm for calculating the recognition probability is based on efficient recurrence procedures for evaluating the single-chain partition function of a chain macromolecule consisting of multiple monomer types, which interact with multiple types of adsorption sites. The temperature dependencies of the recognition probability are discussed. We address the critical role of the commensurability between the heteropolymer sequence and the distribution of the surface adsorbing sites on the polymer adsorption. Also, we address the question of how many types of monomer units in the heteropolymer are required for unambiguous recognition of compact target patterns. It is shown that perfect pattern recognition can be achieved for the strong-adsorption regime in the case of specifically structured compact patterns with multifunctional adsorption sites and heteropolymers with multiple monomer types when the degeneracy of the ground state is suppressed. The pattern recognition ability increases with the number of different types of monomer units and complementary adsorption sites. For random heteropolymers and patterns, the free energy change associated with the recognition process decreases linearly with increasing this number. Correlated random heteropolymers are capable of recognizing related patterns on a random background.

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Section: Introductionmentioning

confidence: 99%

Recognition of complex patterned substrates by heteropolymer chains consisting of multiple monomer types

Kriksin

Khalatur

Khokhlov

2006

The Journal of Chemical Physics

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“…Specific interaction between a polymer and a solid substrate is a key ingredient of the problem related to understanding how the polymer can recognize a target surface having a designated pattern. 11 In recent years, studies of polymer adsorption onto homogeneous flat and curved surfaces, [12][13][14][15][16][17][18][19] homopolymer and heteropolymer adsorption onto disordered and ordered patterned surfaces [20][21][22][23] have been reported ͑for recent reviews, see Refs. A large number of techniques for creation of patterned surfaces are known.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of multiblock copolymers onto a chemically heterogeneous surface: A model of pattern recognition

Kriksin

Khalatur

Khokhlov

2005

The Journal of Chemical Physics

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We present a statistical mechanical model, which is used to investigate the adsorption behavior of two-letter (AB) copolymers on chemically heterogeneous surfaces. The surfaces with regularly distributed stripes of two types (A and B) and periodic multiblock copolymers (Al)B(l))(x) are studied. It is assumed that A(B)-type segments selectively adsorb onto A(B)-type stripes. It is shown that the adsorption strongly depends on the copolymer sequence distribution and the arrangement of selectively adsorbing regions on the surface. The polymer-surface binding proceeds as a two-step process. At the first step, the copolymer having short blocks adsorbs onto the surface as an effective homopolymer, which does not feel chemical pattern. At the second step, when the polymer-surface attraction is sufficiently strong, the adsorbed chain adjusts its equilibrium conformation to reach the perfect bound state, thereby demonstrating ability for pattern recognition. The key element of this mechanism is the redistribution of strongly adsorbed copolymer diblocks A(l)B(l), which behave as surfactants, between multiple AB interfaces separating A and B stripes on the adsorbing surface. Such redistribution is accompanied by a well-pronounced decrease in the system entropy. We have found that marked pattern recognition is possible for copolymers with relatively short blocks at high polymer/surface affinities, beyond the adsorption threshold.

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“…Diffusion involves migration of water into preexisting or dynamically formed spaces between hydrogel chains. Swelling of the hydrogel involves larger scale segmental motion resulting, ultimately, in an increased distance of separation between hydrogel chains [29]. …”

Section: Resultsmentioning

confidence: 99%

Biopolymeric Formulations for Biocatalysis and Biomedical Applications

Elnashar

Kahil

2014

BioMed Research International

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Three gel disks formulations prepared using chitosan (Chito) or polyethylenimine (PEI) followed by glutaraldehyde were prepared for biocatalysis and biomedical applications. The carriers have been used to immobilize lactase covalently and it was evaluated in terms of enzyme loading capacity and enzyme kinetics (km and Vmax). The Km of the Chito formulation was almost half that of the PEI formulations, which is favored in industries. On the other hand, the gel disks were evaluated in terms of their swelling kinetics and the gels' morphology using SEM. The mechanism of the three gels' swelling was also studied and it was found to be non-Fickian, where the mechanism of transport depends on both the diffusion and polymer relaxation, which are controlling the overall rate of water uptake. The Chito formulation was 2–5 folds and PEI formulations were 33–62 folds in terms of the swelling rate constant and the diffusion rate, respectively. These results were highly supported by the SEM. This study will help scientists to design the right polymer network for enzymes immobilization as well as control the surface area and the swelling power of the polymers for different applications such as drug delivery systems and tissue engineering.

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Template Polymerization

Cited by 18 publications

References 75 publications

Recognition of complex patterned substrates by heteropolymer chains consisting of multiple monomer types

Recognition of complex patterned substrates by heteropolymer chains consisting of multiple monomer types

Adsorption of multiblock copolymers onto a chemically heterogeneous surface: A model of pattern recognition

Biopolymeric Formulations for Biocatalysis and Biomedical Applications

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