Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity

Wang, Fang; Qi, Xiongwei; Geng, Jiahong; Liu, Xiaoyan; Liu, Dong; Zhang, Hui; Zhang, Peng; He, Xiaoyun; Li, Baowei; Li, Zhijia; Yu, Rongmin; Yang, Xiaoying; Wang, Guangshuo

doi:10.1016/j.molliq.2021.118000

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…Interestingly, what can be clearly seen is that during the application of the AC magnetic field, the main release of ibuprofen occurred in the early stages of the process. This result shows a faster drug release and/or higher efficiency compared to the ones observed on similar stimulus-responsive Fe 3 O 4 –SiO 2 nanocarriers, and independent of the triggering agent used during the desorption process are the pH − and electric or magnetic fields. − Therefore, to study the dynamics of this process, the cumulative release efficiency of the drug was determined by measuring the amount of ibuprofen accumulated 2, 4, 6, 10, 25, and 30 min after the absorption process had ended (Figure d). In this case, the cumulative drug release at sink condition efficiency was measured during an isothermal process at 37 °C and the magnetic hyperthermia process.…”

Section: Resultsmentioning

confidence: 83%

Fe₃O₄–SiO₂ Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

et al. 2022

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Hybrid magnetic nanoparticles made up of an iron oxide, Fe 3 O 4 , core and a mesoporous SiO 2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and sol−gel approaches and using organic molecules as a porous scaffolding template. The system presents a mean particle diameter of 30( 5) nm (9 nm magnetic core diameter and 10 nm silica shell thickness) with superparamagnetic behavior, saturation magnetization of 32 emu/g, and a significant AC magnetic-field-induced heating response (SAR = 63 W/g Fed 3 Od 4 , measured at an amplitude of 400 Oe and a frequency of 307 kHz). Using ibuprofen as a model drug, the specific surface area (231 m 2 /g) of the porous structure exhibits a high molecule loading capacity (10 wt %), and controlled drug release efficiency (67%) can be achieved using the external AC magnetic field for short time periods (5 min), showing faster and higher drug desorption compared to that of similar stimulus-responsive iron oxide-based nanocarriers. In addition, it is demonstrated that the magnetic fieldinduced drug release shows higher efficiency compared to that of the sustained release at fixed temperatures (47 and 53% for 37 and 42 °C, respectively), considering that the maximum temperature reached during the exposure to the magnetic field is well below (31 °C). Therefore, it can be hypothesized that short periods of exposure to the oscillating field induce much greater heating within the nanoparticles than in the external solution.

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Section: Resultsmentioning

confidence: 83%

Fe₃O₄–SiO₂ Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

et al. 2022

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“…h‐Fe 3 O 4 was synthesized by a template‐free solvothermal approach 20 . As illustrated in Figure 1A, CO(NH 2 ) 2 generally decomposes and generates CO 2 and NH 3 under hydrothermal conditions.…”

Section: Methodsmentioning

confidence: 99%

Enhanced microwave absorption performance of geopolymer composites by incorporating hollow Fe₃O₄ nanospheres

Ding,

Bai,

Wang

et al. 2023

Int J Applied Ceramic Tech

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Hollow Fe3O4 nanospheres (h‐Fe3O4) with tunable sizes were synthesized and proposed as fillers to prepare microwave absorbing geopolymer (GP) composites. We studied the effect of different sizes of h‐Fe3O4 on microwave absorption (MA). The MA performance was enhanced as the size of h‐Fe3O4 in GP decreased. Furthermore, the GP composites containing h‐Fe3O4 achieved better MA capability than their counterparts containing solid Fe3O4 nanospheres (s‐Fe3O4) of the same size. The GP composites with a small size of h‐Fe3O4 exhibited the best minimum reflection loss (RLmin) of −39.3 dB at 14.0 GHz and an effective absorption bandwidth (EAB) of 4.8 GHz at 2.2 mm. The outstanding MA capability, possibly as a result of improved dielectric loss and magnetic loss together with well‐matched impedance, demonstrated that GP composites are competitive construction materials when MA is critical. The radar cross section (RCS) simulation was conducted to assess the MA performance of composite materials in practical environments.

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“…The in vitro cytotoxicity tests demonstrated the neglected effect of the delivery system on cell viability, while only the DOX-loaded nanosphere displayed a cytotoxic effect on selected cancer cells. In continuing these studies, hollow mesoporous Fe 3 O 4 nanospheres were acquired without incorporating a template [27]. The hollow structure, mesoporous shell, and rough surface facilitated high DOX loading capacity without using high initial drug concentration.…”

Section: New Hybrid Systems For Potential Targeted Deliverymentioning

confidence: 99%

Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery

Kurczewska,

Dobosz

2024

Applied Sciences

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Magnetite-based nanoparticles are of constant interest in the scientific community as potential systems for biomedical applications. Over the years, the ability to synthesize diverse systems based on iron (II, III) oxide nanoparticles has been mastered to maximize their potential effectiveness in the targeted delivery of active substances in cancer therapy. The present review explores recent literature findings that detail various magnetic nanosystems. These encompass straightforward designs featuring a polymer coating on the magnetic core and more intricate matrices for delivering chemotherapeutic drugs. This paper emphasizes novel synthetic approaches that impact the efficacy and progress of anticancer investigations, specifically targeting a particular cancer type. The research also delves into combinations with alternative treatment methods and diagnostic approaches. Additionally, it highlights a critical aspect—the interaction with cells—identifying it as the least developed aspect in current research on these systems.

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Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity

Cited by 12 publications

References 32 publications

Fe₃O₄–SiO₂ Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

Fe₃O₄–SiO₂ Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

Enhanced microwave absorption performance of geopolymer composites by incorporating hollow Fe₃O₄ nanospheres

Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery

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Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity

Cited by 12 publications

References 32 publications

Fe3O4–SiO2 Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

Fe3O4–SiO2 Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

Enhanced microwave absorption performance of geopolymer composites by incorporating hollow Fe3O4 nanospheres

Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery

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Fe₃O₄–SiO₂ Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

Fe₃O₄–SiO₂ Mesoporous Core/Shell Nanoparticles for Magnetic Field-Induced Ibuprofen-Controlled Release

Enhanced microwave absorption performance of geopolymer composites by incorporating hollow Fe₃O₄ nanospheres