Tempest about T-lymphocyte apheris in Crohn's disease

Clinical trial: five or ten cycles of granulocyte–monocyte apheresis show equivalent efficacy and safety in ulcerative colitis

“…6,8 Several studies have indicated that GMA apheresis is effective in inducing remission in patients with IBD even after failure of conventional treatments. [9][10][11] Conventional apheresis treatment for inflammatory bowel diseases (IBDs) in the European Union uses 5 consecutive weekly treatments as standard. 12 However, in other countries, 10 or more GMA apheresis treatments are often used in patients with active UC.…”

Lymphocyte and macrophage interleukin receptors in inflammatory bowel disease: a more selective target for therapy?

“…T lymphocyte depletion may be of benefit in treatment of patients with steroid resistant Crohn's disease. 63 The recent report of the onset of complete remission in a patient with severe Crohn's disease as CD4 counts fell as a result of HIV infection underlined the important role of CD4 helper T cells in the pathogenesis of this disease.3064 (A similar phenomenon has recently been described in rheumatoid arthritis.65) This raises the possibility that depletion of specific lymphocyte subsets may be useful in treatment. Monoclonal antibodies against CD4 have been used successfully in treatment of inflammatory bowel disease in a pilot study.66…”