2018
DOI: 10.1080/23328940.2018.1475831
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Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms

Abstract: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by demyelination of the central nervous system (CNS). The exact cause of MS is still unknown; yet its incidence and prevalence rates are growing worldwide, making MS a significant public health challenge. The heterogeneous distribution of demyelination within and between MS patients translates in a complex and varied array of autonomic, motor, sensory and cognitive symptoms. Yet a unique aspect of MS is the highly prevalent (60-80… Show more

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Cited by 60 publications
(54 citation statements)
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“…The mechanisms behind this phenomenon include changes in the axons affected by the demyelination and also in the ion channels due to the changes in the body temperature that result in diminished or blocked transmission through those fibers. Preeminently lesions in the brainstem rather than in the hypothalamus would be involved (3). Cold sensitivity is also causing worsening of symptoms among patients, with a higher proportion of them complaining about it during winter than during cold baths, demyelinating lesions in the hypothalamus being primarily involved (3).…”
Section: Autonomic Dysfunctions In Ms Patientsmentioning
confidence: 99%
See 2 more Smart Citations
“…The mechanisms behind this phenomenon include changes in the axons affected by the demyelination and also in the ion channels due to the changes in the body temperature that result in diminished or blocked transmission through those fibers. Preeminently lesions in the brainstem rather than in the hypothalamus would be involved (3). Cold sensitivity is also causing worsening of symptoms among patients, with a higher proportion of them complaining about it during winter than during cold baths, demyelinating lesions in the hypothalamus being primarily involved (3).…”
Section: Autonomic Dysfunctions In Ms Patientsmentioning
confidence: 99%
“…Preeminently lesions in the brainstem rather than in the hypothalamus would be involved (3). Cold sensitivity is also causing worsening of symptoms among patients, with a higher proportion of them complaining about it during winter than during cold baths, demyelinating lesions in the hypothalamus being primarily involved (3).…”
Section: Autonomic Dysfunctions In Ms Patientsmentioning
confidence: 99%
See 1 more Smart Citation
“…Overwhelming new information has been recently published about the immunological background of this disease, and new drugs are being developed, based on this information. Thermoregulatory dysfunction in multiple sclerosis is becoming the new focus of interest [4]. Chapter 42, written by Scott L. Davis, Ollie Jay and Thad E. Wilson, summarizes the present knowledge of thermoregulatory dysfunction in this disease and gives inspiration for further research to better understand the increased temperature sensitivity in multiple sclerosisa major determinant of the quality of life of these patients.…”
Section: Section Vii: Thermoregulation In Neurological Diseasementioning
confidence: 99%
“…Heat sensitivity is especially prevalent in those with multiple sclerosis , where 60 to 80% of people report worsening neurological symptoms as body temperature rises. Elevated body temperature typically occurs via a combination of warm environments (passive) and physical activity (active), which may predispose neurology patients to greater negative effects on overall health; excess heat also exacerbates fatigue, cognitive impairment, and balance loss (Christogianni et al 2018 ). Motor neuron diseases , such as amyotrophic lateral sclerosis, are also at increased risk of heat-related illness due to a combination of altered thermoregulatory capacity in the severely disabled, and cognitive deficit (Dupuis et al 2018 ).…”
mentioning
confidence: 99%