Temperature-Sensitive Hybrid Microgels with Magnetic Properties

Pich, Andrij; Bhattacharya, Sanchita; Lü, Yan; Boyko, Volodymyr; Adler, Hans‐Juergen P.

doi:10.1021/la040084f

Cited by 137 publications

(115 citation statements)

References 21 publications

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“…In particular, microgels containing thermoresponsive PVCL and a hydrophobic monomer, acetoxy ethylmethacrylate, were prepared and loaded with the nanoparticles. These microgels showed thermoresponsive swelling/deswelling whilst stabilizing the suspension of nanoparticles [157].…”

Section: Particlesmentioning

confidence: 99%

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Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Particlesmentioning

confidence: 99%

“…Pitch et al demonstrated the stabilisation of magnetite nanoparticles by a thermoresponsive polymer [157]. In particular, microgels containing thermoresponsive PVCL and a hydrophobic monomer, acetoxy ethylmethacrylate, were prepared and loaded with the nanoparticles.…”

Section: Particlesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…The effects of the magnetic fields on strain (Faidley et al 2010), shape (Raikher and Stolbov 2005;Zrínyi et al 1997), water retention François et al 2007), stiffness (Mitsumata et al 1999), and the effect of the polymeric matrix on the structural and magnetic properties (Longo et al 2012) have been reported. Because of these properties, ferrogels have many potential applications in the fields of pharmaceutics and medicine as biomembranes, biosensors, artificial muscles, and matrices for drug delivery, among others (Furukawa et al 2003;Gonzalez et al 2012;Liu et al 2006;Mao et al 2005;Miyata et al 2002;Pich et al 2004;Qiu and Park 2001;Sivudu and Rhee 2009).…”

Section: Introductionmentioning

confidence: 99%

Magnetic properties study of iron-oxide nanoparticles/PVA ferrogels with potential biomedical applications

et al. 2013

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A study of the magnetic behavior of maghemite nanoparticles (NPs) in polyvinyl alcohol (PVA) polymer matrices prepared by physical crosslinking is reported. The magnetic nanocomposites (ferrogels) were obtained by the in situ co-precipitation of iron salts in the presence of PVA polymer, and subsequently subjected to freezing-thawing cycles. The magnetic behavior of these ferrogels was compared with that of similar systems synthesized using the glutaraldehyde. This type of chemical crosslinking agents presents several disadvantages due to the presence of residual toxic molecules in the gel, which are undesirable for biological applications. Characteristic particle size determined by several techniques are in the range 7.9-9.3 nm. The iron oxidation state in the NPs was studied by X-ray absorption spectroscopy. Mössbauer measurements showed that the NP magnetic moments present collective magnetic excitations and superparamagnetic relaxations. The blocking and irreversibility temperatures of the NPs in the ferrogels, and the magnetic anisotropy constant, were obtained from magnetic measurements. An empirical model including two magnetic contributions (large NPs slightly departed from thermodynamic equilibrium below 200 K, and small NPs at thermodynamic equilibrium) was used to fit the experimental magnetization curves. A deviation from the superparamagnetic regime was observed. This deviation was explained on the basis of an interacting superparamagnetic model. From this model, relevant magnetic and structural properties were obtained, such as the magnitude order of the dipolar interaction energy, the NPs magnetic moment, and the number of NPs per ferrogel mass unit. This study contributes to the understanding of the basic physics of a new class of materials that could emerge from the PVA-based magnetic ferrogels.

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“…[1][2][3][4][5] They are widely applied in many fields, including biomaterials, sensor, drug delivery, and separation. [6][7][8][9][10][11] The spherical polyelectrolyte brushes (SPBs), prepared by photoemulsion polymerization, are stable colloid systems and sensitive to stimulations through functional polymer chains and modified cores.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of bifunctional spherical polyelectrolyte brushes

Cang

Zhang

Fang

et al. 2016

Designed Monomers and Polymers

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In this work, we prepared two kinds of dual-responsive spherical polyelectrolyte brushes (SPBs) with narrow distribution, of which cores were composed of polystyrene and grafting from copolymers of poly(N-isopropyl acrylamide-co-acrylic acid) (P(NIPAM-AA)) and poly(acrylic acid-co-N,N-diethyl acrylamide) (P(AA-DEA)), respectively. Both kinds of SPBs could response to pH and temperature stimulations by swelling/deswelling shell and electrophoretic mobility (EPM) changes. The low critical solution temperature of SPBs can be fine-tuned in the range of 28-45 ℃ at pH 3-9. Due to the different reactivity of comonomers (NIPAM and AA or DEA and AA), the acrylic acid (AA) unties were distributed at the inner shell of P(AA-DEA) and outer shell of P(NIPAM-AA), respectively, which led to different responses toward pH, temperature, and ionic strength, such as the abnormal 'salt effect' of P(AA-DEA) at low ionic strength and lower shell shrinkage ratio (SR) of P(NIPAM-AA). The dye adsorption in SPBs further confirmed the distribution of AA units.

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Temperature-Sensitive Hybrid Microgels with Magnetic Properties

Cited by 137 publications

References 21 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

Magnetic properties study of iron-oxide nanoparticles/PVA ferrogels with potential biomedical applications

Fabrication and characterization of bifunctional spherical polyelectrolyte brushes

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