Temperature sensitive contact lenses for triggered ophthalmic drug delivery

Ocular Drug Delivery Role of Contact Lenses

“…61,62 Vitamin E loaded silicone contact lenses provided anaesthetic release for about 1-7 days and released 0.5 mg of lidocaine and thus could be very useful for postoperative pain control after corneal surgery such as the photorefractive keratectomy.Vitamin E loaded silicone ISSN 0972-0200 hydrogel contact lenses released 0.5 mg of lidocaine 63 and provided cyclosporine release within the therapeutic window for a period of about a month. 64 Similarily, contact lenses release of 0.5 to 0.7 mg of timolol was reported by Jung et al 25 …”

“…25 The simplest way to incorporate a drug into SCLs is to soak preformed lenses in the drug solution. Conventional soft contact lenses have the ability to absorb a number of drugs when the lenses are pre soaked in the drug solution, subsequently releasing them into the post lens lacrimal fluid.…”

A New Preparation Method for Ophthalmic Drug Nanoparticles

“…Techniques were planned to transform nanoparticles from lipophilic to hydrophilic and to down-regulate irritation to the eye. Preparations that include nanoparticles could be very useful for the extended delivery of ophthalmic drugs [2, 27,28]. Preparations that include nanoparticles have been used to deliver ocular drugs to target sites in the treatment of many eye diseases as summarized in Table 1 [13,29].…”

Nanomedicine and its role in Ophthalmology

“…37,38,39 Nanoparticle-drug loaded contact lenses were studied by Chauhan et al They observed extended drug delivery, better corneal bioavailability and improved patient compliance. 40 Molecularly-imprinted silicone hydrogel contact lenses were prepared by Byrne et al for delivery of small molecule such as ketotifen fumarate and large molecules such as high molecular weight hyaluronic acid and found better bioavailabilty.…”