Temperature responsive hydrogel with reactive nanoparticles

Xiao, Li; Isner, Austin B.; Hilt, J. Zach; Bhattacharyya, Dibakar

doi:10.1002/app.38335

Cited by 23 publications

(19 citation statements)

References 61 publications

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“…A MWCNT (>95% MWCNT U.S. Research Nanomaterials) solution was made by mixing 10 g of MWCNT with 200 mL of 1 M HNO 3 . The MWCNT solution was then sonicated for 2.5 h. The solution was left overnight and then decanted with filter paper.…”

Section: Paam-mwcnt Compositementioning

confidence: 99%

Electromechanical Properties of Carbon Nanotube Infused Polyacrylamide Hydrogel

et al. 2014

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Typically, electroresponsive hydrogels have either a high electrical conductivity with little swelling or large swelling with low conductivity. This paper investigates a method of maintaining high swelling capabilities and increasing electrical conductivity by infusing multiwalled carbon nanotubes (MWCNTs) into a hydrolyzed polyacrylamide hydrogel. Various concentrations of MWCNT and Nafion solutions infused into the hydrogel were investigated. Optical microscopy analysis showed aggregates of carbon nanotube bundles at the macroscale, whereas electron microscopy revealed homogeneous dispersion of carbon nanotube in the polymer matrix at the microscale. Electrical conductivity measurements demonstrated an increase from 0.02 to 0.11 mS cm -1 with infused MWCNT. The MWCNT-infused hydrogels demonstrated a 400% increase in deswelling capabilities during an applied electrical stimulus compared to a noninfused hydrogel. In conclusion, infusing the MWCNT into the hydrogel increased its electrical conductivity, which allows the hydrogel to deswell more rapidly with an applied electrical bias without compromising its mechanical or swelling properties. C

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Section: Paam-mwcnt Compositementioning

confidence: 99%

Electromechanical Properties of Carbon Nanotube Infused Polyacrylamide Hydrogel

et al. 2014

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“…In our previous publication[48], PNIPAAm-PAA hydrogel has been used as support to immobilized nanoparticles and used in the degradation of toxic chloro-organics with improved reactivity by the temperature responsive polymer. In this work, the hydrogel was filled within the membrane to increase the mechanical strength and can be used under convective flow to reduce the mass transfer resistance.…”

Section: Resultsmentioning

confidence: 99%

Development of bench and full-scale temperature and pH responsive functionalized PVDF membranes with tunable properties

Xiao

Isner

Waldrop

et al. 2014

Journal of Membrane Science

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Temperature and pH responsive polymers (poly(N-isopropylacrylamide) (PNIPAAm), and polyacrylic acid, PAA) were synthesized in one common macrofiltration PVDF membrane platform by pore-filling method. The microstructure and morphology of the PNIPAAm-PVDF, and PNIPAAm-FPAA-PVDF membranes were studied by attenuated total reflectance Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The membrane pore size was controlled by the swelling and shrinking of the PNIPAAm at the temperature around lower critical solution temperature (LCST). The composite membrane demonstrated a rapid and reversible swelling and deswelling change within a small temperature range. The controllable flux makes it possible to utilize this temperature responsive membrane as a valve to regulate filtration properties by temperature change. Dextran solution (Mw=2,000,000g/mol, 26 nm diameter) was used to evaluate the separation performance of the temperature responsive membranes. The ranges of dextran rejection are from 4% to 95% depending on the temperature, monomer amount and pressure. The full-scale membrane was also developed to confirm the feasibility of our bench-scale experimental results. The full-scale membrane also exhibited both temperature and pH responsivity. This system was also used for controlled nanoparticles synthesis and for dechlorination reaction.

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“…This idea of incorporating particles into hydrogel for detoxification purposes has been demonstrated by early studies454647. We propose to shape the PEG matrix encapsulated with PDA nanoparticles into a designer structure using 3D printing, a disruptive technology that is finding promising applications in creating unique 3D devices and tissue constructs4849.…”

Section: Discussionmentioning

confidence: 99%

Bio-inspired detoxification using 3D-printed hydrogel nanocomposites

Gou¹,

et al. 2014

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Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of nanoparticles for detoxification often leads to nanoparticle accumulation in the liver, posing a risk of secondary poisoning especially in liver-failure patients. Here we present a liver-inspired three-dimensional (3D) detoxification device. This device is created by 3D printing of designer hydrogels with functional polydiacetylene nanoparticles installed in the hydrogel matrix. The nanoparticles can attract, capture and sense toxins, while the 3D matrix with a modified liver lobule microstructure allows toxins to be trapped efficiently. Our results show that the toxin solution completely loses its virulence after treatment using this biomimetic detoxification device. This work provides a proof-of-concept of detoxification by a 3D-printed biomimetic nanocomposite construct in hydrogel, and could lead to the development of alternative detoxification platforms.

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Temperature responsive hydrogel with reactive nanoparticles

Cited by 23 publications

References 61 publications

Electromechanical Properties of Carbon Nanotube Infused Polyacrylamide Hydrogel

Electromechanical Properties of Carbon Nanotube Infused Polyacrylamide Hydrogel

Development of bench and full-scale temperature and pH responsive functionalized PVDF membranes with tunable properties

Bio-inspired detoxification using 3D-printed hydrogel nanocomposites

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