Temperature-responsive cationic block copolymers as nanocarriers for gene delivery

Calejo, Maria Teresa; Cardoso, Ana M.; Kjøniksen, Anna–Lena; Zhu, Kaizheng; Morais, Catarina M.; Sande, Sverre Arne; Lima, Maria C. Pedroso de; Jurado, Amália S.; Nyström, Bo

doi:10.1016/j.ijpharm.2013.03.028

Cited by 36 publications

(31 citation statements)

References 39 publications

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“…214,216,217 The pros and cons of the above-mentioned approaches can be considered in three areas: production, safety, and efficiency, which are described in Table 3.…”

Section: Temperature Responsive Nanocarriers For Cargo Deliverymentioning

confidence: 99%

“…Copolymerization of PNIPAAm with other biodegradable polymers (hydrophilic or hydrophobic blocks) would not only partially overcome this drawback but also could alter the LCST of PNI-PAAm. 74,76,216,224–226 A short summary of examples of thermosensitive polymers as gene delivery systems including their features and applications is provided in Table 4.…”

Section: Temperature Responsive Nanocarriers For Cargo Deliverymentioning

confidence: 99%

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Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

314

203

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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“…214,216,217 The pros and cons of the above-mentioned approaches can be considered in three areas: production, safety, and efficiency, which are described in Table 3.…”

Section: Temperature Responsive Nanocarriers For Cargo Deliverymentioning

confidence: 99%

Section: Temperature Responsive Nanocarriers For Cargo Deliverymentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

314

203

View full text Add to dashboard Cite

show abstract

“…2). Moreover, promoted endocytosis and endosomal escape have been confirmed by other systems due to introduction of hydrophobic segments [23,24,35,36]. Accordingly, high-efficiency in vitro and in vivo gene transfection by MPMs at 37 C was observed as compared with SPMs at same N/P ratios likely due to the combined effect of formation of PNIPAM-b-PAsp(DET) micelle architecture, heterogeneous hydrophobic/hydrophilic surface of the polyplex micelles, as well as improved pDNA condensation and micellar stability.…”

Section: Discussionmentioning

confidence: 67%

“…2D). Heterogeneous surfaces on the polyplex micelles could introduce some notable properties including improved pDNA condensation and micellar stability by hydrophobic segments [23,35,36], better protection from nuclease digestion, and enhanced resistance against protein adsorption [37e40] (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas

Feng

Chen

et al. 2015

Biomaterials

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“…Stimuli-responsive polymers have received extensive attention in biotechnological and biomedical applications, especially in drug delivery systems [1,2] and gene delivery carriers [3,4].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Temperature- and pH Dually-responsive Poly(β-amino ester)

Lu¹,

Yang²,

Li³

et al. 2017

dtetr

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Stimuli-responsive polymers have undoubtedly been of great interest in the past few decades due to a variety of potential applications in biomedical territory but their non-degradability limits their in vivo applications. Herein, we report a novel dual-stimuli responsive pH-and temperature-responsive poly(β-amino ester). The pH/temperature sensitivities are interrelated and can be easily tuned by the PEG-diacrylate chain length and the percentage of biamines in the feed ratio. These dually-responsive polymers are very useful in drug delivery.

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Temperature-responsive cationic block copolymers as nanocarriers for gene delivery

Cited by 36 publications

References 39 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas

Biodegradable Temperature- and pH Dually-responsive Poly(β-amino ester)

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