Temperature-responsive and multi-responsive grafted polymer brushes with transitions based on critical solution temperature: synthesis, properties, and applications

Stetsyshyn, Yurij; Raczkowska, Joanna; Harhay, Khrystyna; Gajos, Katarzyna; Melnyk, Yuriy; Dąbczyński, Paweł; Shevtsova, Tetiana; Budkowski, Andrzej

doi:10.1007/s00396-020-04750-0

Cited by 48 publications

(66 citation statements)

References 168 publications

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“…According to Peng et al [ 59 ], the functionalization of CS may increase its water solubility, which may explain the higher homogeneity of CS3-PLA surface. Furthermore, other authors have reported that with increasing molecular weight compounds, the reaction between their end-group and the complementary group on the substrate surface becomes less efficient, which may have a significant role in microbial adhesion and cell growth [ 32 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

et al. 2021

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Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections. Polylactic acid (PLA) and its composites are currently used for the construction of IMDs. In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw). The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation. For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa. Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw. The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA. Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.

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Section: Discussionmentioning

confidence: 99%

Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

et al. 2021

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“…The ultimate goal of such studies is to create materials and products, which are better suitable for diverse applications in biomedicine. In the past few years, such materials were created on the basis of the nanocoatings [ 1 , 2 , 3 ], grafted polymer brushes [ 4 , 5 , 6 , 7 ], nanotubes [ 8 , 9 , 10 , 11 ], hydrogels [ 12 , 13 ], organic and inorganic nanoparticles [ 14 , 15 ], and others. To improve biological action of polymeric materials, they are often modified in different manners.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO3 Nanoparticles on Different Cell Lines

et al. 2021

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In the present work, we have successfully prepared and characterized novel nanocomposite material exhibiting temperature-dependent surface wettability changes, based on grafted brush coatings of non-fouling poly(di(ethylene glycol)methyl ether methacrylate) (POEGMA) with the embedded CaCO3 nanoparticles. Grafted polymer brushes attached to the glass surface were prepared in a three-step process using atom transfer radical polymerization (ATRP). Subsequently, uniform CaCO3 nanoparticles (NPs) embedded in POEGMA-grafted brush coatings were synthesized using biomineralized precipitation from solutions of CaCl2 and Na2CO3. An impact of the low concentration of the embedded CaCO3 NPs on cell adhesion and growth depends strongly on the type of studied cell line: keratinocytes (HaCaT), melanoma (WM35) and osteoblastic (MC3T3-e1). Based on the temperature-responsive properties of grafted brush coatings and CaCO3 NPs acting as biologically active substrate, we hope that our research will lead to a new platform for tissue engineering with modified growth of the cells due to the release of biologically active substances from CaCO3 NPs and the ability to detach the cells in a controlled manner using temperature-induced changes of the brush.

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“…This is based on the light or heat triggered formation of a highly reactive species such as radicals derived from surface coupled initiators, which are able to start the polymerization mostly via addition reactions to multiple bonds. Compared to the “grafting to” mentioned approach, grafting from polymerizations leads to higher grafting densities and film thicknesses [ 1 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Surface-Immobilized Photoinitiators for Light Induced Polymerization and Coupling Reactions

2022

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Straightforward and versatile surface modification, functionalization and coating have become a significant topic in material sciences. While physical modification suffers from severe drawbacks, such as insufficient stability, chemical induced grafting processes efficiently modify organic and inorganic materials and surfaces due to covalent linkage. These processes include the “grafting from” method, where polymer chains are directly grown from the surface in terms of a surface-initiated polymerization and the “grafting to” method where a preformed (macro)-molecule is introduced to a preliminary treated surface via a coupling reaction. Both methods require an initiating species that is immobilized at the surface and can be triggered either by heat or light, whereas light induced processes have recently received increasing interest. Therefore, a major challenge is the ongoing search for suitable anchor moieties that provide covalent linkage to the surface and include initiators for surface-initiated polymerization and coupling reactions, respectively. This review containing 205 references provides an overview on photoinitiators which are covalently coupled to different surfaces, and are utilized for subsequent photopolymerizations and photocoupling reactions. An emphasis is placed on the coupling strategies for different surfaces, including oxides, metals, and cellulosic materials, with a focus on surface coupled free radical photoinitiators (type I and type II). Furthermore, the concept of surface initiation mediated by photoiniferters (PIMP) is reviewed. Regarding controlled radical polymerization from surfaces, a large section of the paper reviews surface-tethered co-initiators, ATRP initiators, and RAFT agents. In combination with photoinitiators or photoredox catalysts, these compounds are employed for surface initiated photopolymerizations. Moreover, examples for coupled photoacids and photoacid generators are presented. Another large section of the article reviews photocoupling and photoclick techniques. Here, the focus is set on light sensitive groups, such as organic azides, tetrazoles and diazirines, which have proven useful in biochemistry, composite technology and many other fields.

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Temperature-responsive and multi-responsive grafted polymer brushes with transitions based on critical solution temperature: synthesis, properties, and applications

Cited by 48 publications

References 168 publications

Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO3 Nanoparticles on Different Cell Lines

Surface-Immobilized Photoinitiators for Light Induced Polymerization and Coupling Reactions

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