Temperature-responsive and biocompatible nanocarriers based on clay nanotubes for controlled anti-cancer drug release

Hemmatpour, Hamoon; Haddadi‐Asl, Vahid; Burgers, Thomas; Yan, Feng; Stuart, Marc C. A.; Reker‐Smit, Catharina; Vlijm, Rifka; Salvati, Anna; Rudolf, Petra

doi:10.1039/d2nr06801j

Cited by 11 publications

(3 citation statements)

References 82 publications

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“…On the other hand, thermal stimulation has a vasodilating effect and alters the permeability of tumor cell membranes, thus facilitating the delivery of antitumor drugs and local drug concentration, and enhancing the antitumor effect. Heat-sensitive materials are usually temperature-controlled by a temperature-sensitive material in a nanosystem, which triggers a change in the nanosystem upon warming, triggering drug release [92,93]. Typically, thermosensitive nanosystems remain stable at 37°C and can trigger rapid drug delivery after reaching 40-42°C, minimizing drug leakage due to blood circulation and metabolism at the tumor site [31].…”

Section: Temperature-responsive Nanocarriersmentioning

confidence: 99%

Shoot the Arrow at the Target: Innovative Stimulus-Responsive Smart Nanocarriers for Cancer Therapy

Liu,

He,

Liu

2024

Preprint

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With the breakthroughs and innovative developments in nanotechnology, research on the application of nanomedicine in cancer therapy has so far seen tremendous expansion and success. Intelligent stimulus-responsive nanocarriers are an emerging field of research and have great interest in cancer therapy owing to the fascinating properties such as excellent targeting function, high drug loading capacity, and targeted on-demand release properties. Responsive nanomaterials can be designed and constructed according to the dosing context and therapeutic needs, at the same time, activated by internal bio-stimuli (pH, redox, and enzymes) and/or external stimuli (ultrasound, light, temperature, and magnetic), respectively. What’s more, smart nanocarriers are also utilized for the precise and controllable release of antitumor drugs from cancer tissues and cells to achieve efficient diagnosis and treatment of tumors. Deeply investigated, responsive nanocarriers have attracted considerable attention due to their ability to release precisely at tumor-specific sites. Herein, we review the recent advances of novel stimuli-responsive nanocarriers in the field of cancer therapy. Finally, the challenges and application prospects of smart nanocarriers are further elaborately discussed.

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Section: Temperature-responsive Nanocarriersmentioning

confidence: 99%

Shoot the Arrow at the Target: Innovative Stimulus-Responsive Smart Nanocarriers for Cancer Therapy

Liu,

He,

Liu

2024

Preprint

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“…Drug delivery systems are recognized as efficient adjuvant therapy for bone tumors to avoid the strong side effects caused by conventional chemotherapy − and also to probe the tumor and surrounding area to obtain images for monitoring potential events associated. , Clinical studies have shown that nanomaterials loaded with antitumor drugs can circumvent the side effects caused by systemic administration to the greatest extent compared to free drugs. − These nanocarriers can improve drug permeability by sensing environmental stimuli (such as pH, temperature, magnetism, and ultrasound), enhancing the permeability retention effect, and lengthening circulation time to realize passive targeting. − …”

Section: Introductionmentioning

confidence: 99%

Titanium Carbide MXene Quantum Dots-Modified Hydroxyapatite Hollow Microspheres as pH/Near-Infrared Dual-Response Drug Carriers

Liu,

Pan,

Gan

et al. 2023

Langmuir

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Titanium carbide MXene quantum dots (MQDs) possess intrinsic regulatory properties and selective toxicity to cancer cells. Here, MDQs were selected for the modification of hydroxyapatite (HA) microspheres, and MXene quantum dots-modified hydroxyapatite (MQDs-HA) hollow microspheres with controllable shapes and sizes were prepared as bone drug carriers. The results show that the prepared MQDs-HA hollow microspheres had a large BET surface area (231.2 m 2 /g), good fluorescence, and low toxicity. In addition, MQDs-HA showed a mild storage−release behavior and good responsiveness of pH and near-infrared (NIR). Thus, the MQDs-HA hollow microspheres have broad application prospects in the field of drug delivery and photothermal therapy.

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“…In a recent work, Hemmatpour et al [17] have synthesized a drug loaded carrier based on the surface modi ed HNT. For this purpose, polydopamine was coated on the surface of HNT, then atom transfer radical polymerization (ATRP) agent was adhered on the surface, and nally poly(N-isopropylacrylamide) (PNIPAM) chains were grown on the surface via a grafting from approach.…”

Section: Introductionmentioning

confidence: 99%

Surface modification of halloysite nanotube with an amine terminated block copolymer

Jafazadeh,

Haddadi-Asl

2023

Preprint

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The surface modification of halloysite nanotube can make it a very prospering vehicle for cancer drug delivery. In the present study, the surface of HNT clay was modified with a copolymer of polyacrylic acid (PAA) and polyaniline (PANI). The copolymer was decorated on the surface via a grafting from strategy. To fulfill this, the surface was firstly modified with an organosilane component, and then with a chain transfer agent (CTA). Later, the copolymer was grown on the surface via subsequent stages of reversible addition fragmentation chain transfer (RAFT) and oxidative polymerizations. The successful formation of copolymer on HNT surface was corroborated by spectroscopic analyses including FTIR and 1HNMR. The morphology of the polymer grafted HNT was studied using electron microscopes, i.e. SEM and TEM, and the results revealed that nanostructures with respective mean diameter and length of 40 and 100 nm possessing polymer coating on the interior and exterior surfaces were obtained. The structural analysis with XRD verified the crystalline structure of HNT was almost preserved in the presence of copolymer graft and only the interlayer distances were increased. The thermal study via DSC confirmed that the copolymer grafted HNT possessed glass transition, melting, and degradation peaks. And TGA analysis unveiled that HNT grafted with copolymer represented higher thermal stability comparing that one grafted with pristine PAA. Moreover, quantitative results of TGA substantiated that more that 59% copolymer was grafted onto HNT surface.

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Temperature-responsive and biocompatible nanocarriers based on clay nanotubes for controlled anti-cancer drug release

Abstract: Administration of temperature-responsive drug carriers that release anticancer drugs at high temperatures can benefit the hyperthermia therapies because of the synergistic effect of anticancer drug molecules and high temperature on...

Cited by 11 publications

References 82 publications

Shoot the Arrow at the Target: Innovative Stimulus-Responsive Smart Nanocarriers for Cancer Therapy

Shoot the Arrow at the Target: Innovative Stimulus-Responsive Smart Nanocarriers for Cancer Therapy

Titanium Carbide MXene Quantum Dots-Modified Hydroxyapatite Hollow Microspheres as pH/Near-Infrared Dual-Response Drug Carriers

Surface modification of halloysite nanotube with an amine terminated block copolymer

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