“…It should also be noted that a difference in the temperature‐induced susceptibility change between fat and aqueous tissues leads to significant temperature error . Moreover, any nonwater signal component, such as fat, needs to be suppressed in order to avoid erroneous phase calculation unless the fat signal is used as an internal reference for measuring water PRF in MR spectroscopy (MRS) . Despite these drawbacks, PRF shift thermometry using the phase mapping method is the only clinically available noninvasive temperature imaging modality for HIFU.…”