Temperature Management Methods for Selective Brain Hypothermia in Variable Metabolism

Abstract

Brain hypothermia is widely operated to prevent peripheral healthy brain tissue from secondary damage, caused by increased brain temperature due to hypermetabolism around the damaged areas. Selective brain hypothermia is a new clinical technique of brain hypothermia for a brain disorder. Appropriate solution in a controlled temperature is directly infused into the artery to cool down a brain tissue through some catheters. While the brain temperature is controlled quickly, the body temperature has to be kept within a prescribed range by re‐warmed cerebrovascular blood return to the systemic circulation. As metabolic changes in the brain is variable due to the complex behavior of the disease state with the treatment effect. . In the present study two adaptive control methods as adaptive‐gain control and Fuzzy‐adaptive control are provided to carry out for precise temperature control for selective brain hypothermia. Several kinds of mathematical brain models with cerebrovascular damage are specially used to evaluate our temperature control methods. The effectiveness of the management of the brain temperature is demonstrated for four kinds control laws and five mathematical clinical brain models. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.