Temperature Instability of ReNu With MoistureLoc

Bullock, John D.; Warwar, Ronald E.; Elder, B. Laurel; Northern, William I.

doi:10.1001/archopht.126.11.1493

Cited by 27 publications

(5 citation statements)

References 21 publications

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“…After extended periods of storage, the disinfecting efficacy of polyhexanide-based MPSs may decrease due to the accumulation of polyhexanide on the CL material or CL case [70,92]; iii. higher storage temperatures can lead to decreased disinfecting efficacies [93]; longer storage times of open hydrogen-peroxide-based CL care solutions can lead to a decrease of the hydrogen peroxide concentration and thus decreased disinfecting efficacy.…”

Section: Discussionmentioning

confidence: 99%

In-vitroanalysis of the microbicidal activity of 6 contact lens care solutions

et al. 2012

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BackgroundContact lens-related infections are often associated with inadequate contact lens hygiene, and therefore, contact lens care products should be able to sufficiently minimise the amount of pathogens that are responsible for these infections. In 2001, the EN ISO 14729 was introduced to ensure adequate disinfection efficacy of contact lens care solutions, but this norm has recently been criticised.MethodsIn this study, six frequently used contact lens care solutions were retested according to the Stand Alone Test of the EN ISO 14729 (2001). The Stand Alone Test is a quantitative suspension test. In addition, the products were tested in a modified setting adding an organic load. The load was a mixture of human blood serum, lysozyme, and mucine, which resembles tear fluid.ResultsThe criteria of the Stand Alone Test recommended in EN ISO 14729 were only met by Aosept Plus. This 3% hydrogen-peroxide-based contact lens care solution attained a reduction factor of > 5 log units for bacteria and > 4 for fungi in all cases. Two further contact lens care solutions, Blue Vision and Optifree Replenish, met the criteria of a reduction factor of > 3 log units for bacteria and > 1 log unit for fungi, but only in the presence of artificial tear fluid. The three remaining products did not exhibit adequate disinfecting efficacy, at least against one of the tested microorganisms.ConclusionsThrough the observation that the artificial tear fluid used in this study influences the disinfecting efficacy of contact lens care solutions, especially that of multi-purpose solutions, in a different way than does albumin, mucine, or even the organic load suggested in EN ISO 14729, it becomes obvious that the test conditions in the EN ISO 14729 should be revised in order to create more realistic conditions, e.g., by using a more realistic artificial tear fluid. Furthermore, we suggest adapting the EN ISO 14729 to the European test hierarchy for chemical disinfectants and antiseptics, which consists of three test phases and also requests meeting stricter criteria in order to pass the test. Unless the test conditions guarantee a sufficient reduction of potential pathogens, the risk of contact lens-related microbial keratitis and other infections will remain for the users.

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Section: Discussionmentioning

confidence: 99%

In-vitroanalysis of the microbicidal activity of 6 contact lens care solutions

et al. 2012

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“…All of our cases were related to use of EzriCare artificial tears, and 3 EzriCare bottles were brought in for culture that yielded XDR isolates (excluding partial polymyxin B sensitivity in case 9). Various incidents of contaminated ocular medications predate the 2023 artificial tear recall, including the 2005 Fusarium keratitis-linked Bausch & Lomb recall of contact lens disinfectant and the 2007 Acanthamoeba keratitis–linked Advanced Medical Optics recall of contact lens solution …”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis

Tribin,

Lieux,

Maestre-Mesa

et al. 2024

JAMA Ophthalmol

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ImportanceEvaluation of the microbiological diagnostic profile of multidrug-resistant Pseudomonas aeruginosa keratitis and potential management with rose bengal–photodynamic antimicrobial therapy (RB-PDAT) is important.ObjectiveTo document the disease progression of carbapenemase-resistant P aeruginosa keratitis after an artificial tear contamination outbreak.Design, Setting, and ParticipantsThis retrospective observation case series included 9 patients 40 years or older who presented at Bascom Palmer Eye Institute and had positive test results for multidrug-resistant P aeruginosa keratitis between January 1, 2022, and October 31, 2023.Main Outcomes and MeasuresEvaluation of type III secretion phenotype, carbapenemase-resistance genes blaGES and blaVIM susceptibility to antibiotics, and in vitro and in vivo outcomes of RB-PDAT against multidrug-resistant P aeruginosa keratitis.ResultsAmong the 9 patients included in the analysis (5 women and 4 men; mean [SD] age, 73.4 [14.0] years), all samples tested positive for exoU and carbapenemase-resistant blaVIM and blaGES genes. Additionally, isolates were resistant to carbapenems as indicated by minimum inhibitory concentration testing. In vitro efficacy of RB-PDAT indicated its potential application for treating recalcitrant cases. These cases highlight the rapid progression and challenging management of multidrug-resistant P aeruginosa. Two patients were treated with RB-PDAT as an adjuvant to antibiotic therapy and had improved visual outcomes.Conclusions and RelevanceThis case series highlights the concerning progression in resistance and virulence of P aeruginosa and emphasizes the need to explore alternative therapies like RB-PDAT that have broad coverage and no known antibiotic resistance. The findings support further investigation into the potential effects of RB-PDAT for other multidrug-resistant microbes.

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“…Fusarium species are ubiquitous filamentous fungi that are the most common organism implicated in fungal keratitis, particularly in tropical regions . In 2006, an epidemic of Fusarium keratitis was reported in contact lens wearers who were using Bausch & Lomb ReNU with MoistureLoc (Bauch & Lomb) contact lens solution in the United States and Asia . Many of these patients had severe vision loss, and more than one-third ultimately required corneal transplant for visual rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

“…Many of these patients had severe vision loss, and more than one-third ultimately required corneal transplant for visual rehabilitation. Fusarium has also been recognized as an emerging systemic pathogen in individuals with immunosuppression that is associated with a high mortality rate and little evidence to guide therapy …”

Section: Introductionmentioning

confidence: 99%

Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis

et al. 2017

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; for the Mycotic Ulcer Treatment Trial Group IMPORTANCE Fusarium keratitis is common and often results in poor outcomes. No new treatments since natamycin have become available. OBJECTIVE To explore the role of adjuvant oral voriconazole on clinical outcomes in Fusarium keratitis. DESIGN, SETTING, AND PARTICIPANTS In this prespecified subgroup analysis of a multicenter, double-masked, placebo-controlled randomized clinical trial, 240 patients from the Aravind Eye Care System in India,

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Temperature Instability of ReNu With MoistureLoc

Cited by 27 publications

References 21 publications

In-vitroanalysis of the microbicidal activity of 6 contact lens care solutions

In-vitroanalysis of the microbicidal activity of 6 contact lens care solutions

Clinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis

Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis

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