Temperature-Induced Surface Effects on Drug Nanosuspensions

Aleandri, Simone; Schönenberger, Monica; Niederquell, Andreas; Kuentz, Martin

doi:10.1007/s11095-017-2300-6

Cited by 11 publications

(2 citation statements)

References 33 publications

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“…For this measurement, it is necessary to immerse the samples in a thermal bath that maintains the sample chamber of the instrument at 37°C. 16 , 23 …”

Section: Parameters Evaluated Reflecting Characteristics Of Nanosuspe...mentioning

confidence: 99%

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Nanosuspension-Based Drug Delivery Systems for Topical Applications

Aldeeb,

Wilar,

Suhandi

et al. 2024

IJN

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Nanosuspensions have garnered recent attention as a promising strategy for mitigating the bioavailability challenges of hydrophobic drugs, particularly those characterized by poor solubility in both aqueous and organic environments. Addressing solubility issues associated with poorly water-soluble drugs has largely resolved the need to enhance drug absorption and bioavailability. As mucosal formulations and topical administration progress in the future, nanosuspension drug delivery, straightforward formulation techniques, and versatile applications will continue to be subjects of interest. Nanosuspensions have undergone extensive scrutiny in preparation for topical applications, encompassing ocular, pulmonary, and dermal usage. Among the numerous methods aimed at improving cutaneous application, nanocrystals represent a relatively recent yet profoundly intriguing approach. Despite the increasing availability of various nanosuspension products, primarily designed for oral administration, only a limited number of studies have explored skin permeability and drug accumulation in the context of nanosuspensions. Nevertheless, the scant published research unequivocally underscores the potential of this approach for enhancing cutaneous bioavailability, particularly for active ingredients with low to medium solubility. Nanocrystals exhibit increased skin adhesiveness in addition to heightened saturation solubility and dissolution rate, thereby augmenting cutaneous distribution. The article provides a comprehensive overview of nanosuspensions for topical application. The methodology employed is robust, with a well-defined experimental design; however, the limited sample size raises concerns about the generalizability of the findings. While the results demonstrate promising outcomes in terms of enhanced drug delivery, the discussion falls short of addressing certain limitations. Additionally, the references largely focus on recent studies, but a more diverse inclusion of historical perspectives could offer a more holistic view of the subject.

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“…For this measurement, it is necessary to immerse the samples in a thermal bath that maintains the sample chamber of the instrument at 37°C. 16 , 23 …”

Section: Parameters Evaluated Reflecting Characteristics Of Nanosuspe...mentioning

confidence: 99%

“…Upon dermal absorption, medications can exert their effects locally, regionally, or systemically at various target sites. 23 , 24 These considerations have led to the perception that drug delivery through the skin is a compelling yet challenging research area. The principal obstacle is overcoming the skin’s remarkable impermeability.…”

Section: Introductionmentioning

confidence: 99%

Nanosuspension-Based Drug Delivery Systems for Topical Applications

Aldeeb,

Wilar,

Suhandi

et al. 2024

IJN

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An Enthalpy-Balance Model for Timewise Evolution of Temperature during Wet Stirred Media Milling of Drug Suspensions

et al. 2022

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Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry

Peltonen

2018

Advanced Drug Delivery Reviews

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The number of poorly soluble drug candidates is increasing, and this is also seen in the research interest towards drug nanoparticles and (nano-)cocrystals; improved solubility is the most important application of these nanosystems. In order to confirm the functionality of these nanoparticles throughout their lifecycle, repeatability of the formulation processes, functional performance of the formed systems in pre-determined way and system stability, a thorough physicochemical understanding with the aid of necessary analytical techniques is needed. Even very minor deviations in for example particle size or size deviation in nanoscale can alter the product bioavailability, and the effect is even more dramatic with the smallest particle size fractions. Also, small particle size sets special requirements for the analytical techniques. In this review most important physicochemical properties of drug nanocrystals and nano-cocrystals are presented, suitable analytical techniques, their pros and cons, are described with the extra input on practical point of view.

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Temperature-Induced Surface Effects on Drug Nanosuspensions

Abstract: The combined usage of analytical surface methods provides the basis for a better understanding of phenomena that take place on drug surfaces. Such understanding is of importance for pharmaceutical development to achieve desirable quality attributes of nanosuspensions.

Cited by 11 publications

References 33 publications

Nanosuspension-Based Drug Delivery Systems for Topical Applications

Nanosuspension-Based Drug Delivery Systems for Topical Applications

An Enthalpy-Balance Model for Timewise Evolution of Temperature during Wet Stirred Media Milling of Drug Suspensions

Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry

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