Magnetic tunnel junctions (MTJs) are promising devices for heat-assisted magnetic recording technology. Quantum transport of nanoscale double-barrier MTJs with a middle La0.7Sr0.3MnO3 (LSMO) layer (DBMTJs-LSMO) is investigated by the non-equilibrium Green’s function formalism. The thermopower is described in the linear response regime. The results of the DBMTJs-LSMO show an enhancement of the thermopower compared to DBMTJs-CoFeB and conventional single-barrier MTJs (SBMTJs) due to the LSMO physical properties and also the existence of the quantum-well (QW) states. The parallel (P) and anti-parallel (AP) thermopower of
and
are achieved at room temperature for DBMTJs-LSMO. The tunnel magneto-thermopower ratio is found to be
at room temperature along with its maximum value of
at
for DBMTJs-LSMO.