Temperature gradient between brain tissue and arterial blood mirrors the flow‐metabolism relationship in uninjured brain: an experimental study

Soukup, Jens; Rieger, Andreas; Holz, Carsten; Miko, Iren; Németh, Norbert; Menzel, M.

doi:10.1111/j.1399-6576.2007.01356.x

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…In the brain for example, being able to implant sensors into injured white matter and/or cerebral ventricles [9] has shown variations in organ temperature from deep to superficial structures [14] and across the brain [8] and has revolutionised our understanding of the pathophysiology of brain damage [27,36]. Similar variations in regional tissue temperature have also been reported, with non-invasive imaging of healthy brain using 1 H magnetic resonance spectroscopy ( 1 HMRS) and imaging ( 1 H MRSI) [7].…”

Section: Human Temperature Measurementmentioning

confidence: 58%

Infrared Thermal Mapping, Analysis and Interpretation in Biomedicine

Selvan

Childs

2017

Application of Infrared to Biomedical Sciences

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Section: Human Temperature Measurementmentioning

confidence: 58%

Infrared Thermal Mapping, Analysis and Interpretation in Biomedicine

Selvan

Childs

2017

Application of Infrared to Biomedical Sciences

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“…There are publications also from Australia [38,[198][199][200], Austria [53,85], Brazil [58], Canada [93,118,132,135,139], China [9, 201,202], Croatia [203], the Czech Republic [204], Denmark [134]; Finland [134], France [43,77,114,205,206], Greece [207], Hungary [141], India [208], Japan [140,146,167,209], Portugal [64]; Russia [210,211], Singapore [2,4,10,16,74,212,213]; Serbia [214]; South Africa [26,28,35], South Korea [127], Sweden [90,134,215], Switzerland [11,216,217]...…”

Section: Clinical Applicationsmentioning

confidence: 99%

“…PbtO2 monitoring is almost exclusively used in combination with other cerebral non-invasive and invasive monitoring modalities, in particular intracranial pressure [ICP] monitoring [4, 6, 17, 22, 24, 26, 32, 33, 50, 51, 53, 55, 72, 81, 88 202, 91, 130, 176, 187, 203, 206, 219-223], cerebral perfusion pressure (CPP) monitoring [3,4,10,25,178,187,198,[224][225][226], jugular venous saturation (JvDO2) monitoring [184,190,206,227,228] 88 202, 178, 237], regional cerebral blood flow measurements (rCBF) [47,[240][241][242], near infrared spectroscopy (NIRS) [15,123,179,190,243], intracranial temperature measurements [9,97,99,141], oxygen-15 positron emission tomography (15O-PET) [230], continuous surface electroencephalogram [94], and cortical spreading depolarizations (CSD) monitoring using subdural electrocorticography (ECoG) strip electrodes [244].…”

Section: Clinical Applicationsmentioning

confidence: 99%

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Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Lang

Jaeger²

2013

TOCCMJ

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This review has been compiled to assess publications related to the clinical application of direct cerebral tissue oxygenation (pbtO2) monitoring published in international, peer-reviewed scientific journals, or major meeting reports published as journal supplements. Its goal was to extract relevant, i.e. positive and negative, information on indications, clinical application, safety issues and impact on clinical situations, as well as treatment strategies in neurosurgery, neurosurgical anaesthesiology, neurosurgical intensive care, neurology, and related specialties. For completeness' sake it also presents related basic science research and case reports. This review is an update of its previous edition published elsewhere in 2007. This review reflects publications from 2004 to 2012. Only relevant publications prior to 2004, which explicitly addressed or systematically examined the above issues, are included in this review and are listed in the reference section. Based on 349 citations it is the most comprehensive review available on direct cerebral oxygen monitoring to this date.Keywords: Review, cerebral oxygenation, raumedic, licox, neurotrend, cerebral partial pressure of oxygen, brain tissue oxygenation. METHODSThis review is based on a systematic "Medline" literature search using the following search terms: licox, neurotrend, neurovent, raumedic, brain tissue oxygen, brain tissue oxygenation, cerebral oxygenation, cerebral tissue oxygen, cerebral partial pressure of oxygen, btO2, ptiO2, pti(O)2, ptiO(2), pbrO2, PBr(O2), P(bt)O(2), P(br)O(2), PbrO(2), BTpO2, tP(O2), PbO2, PbtO2, Pbto, PbtO(2).Only few publications were not retrieved using this technique. They were, however, identified through personal communication with scientists in the field, meeting proceedings and reviewer assignments. This strategy provided sufficient certainty that relevant papers have not been missed. Unpublished meeting abstracts and published conference proceedings were excluded for this review expect for few which provided comparative studies between different probes. To address relevant matters, related to specific pbtO2 issues, selected non-peer reviewed papers published in supplements were also used only when no other peer-reviewed information was available. RESULTSThis review is based on a previous review [1]. It is currently based on 349 papers, 274 more papers compared to its previous version in 2007, which warrants the update.

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“…11–14 Similarly, systemic surrogates of brain temperature, such as tympanic or rectal probes, may be inaccurate as estimates of brain temperature, particularly during dysregulation, while similarly unable to address the presence of spatial temperature gradients directly. 15–19 …”

Section: Introductionmentioning

confidence: 99%

Proton Resonance Frequency Chemical Shift Thermometry: Experimental Design and Validation toward High-Resolution Noninvasive Temperature Monitoring and In Vivo Experience in a Nonhuman Primate Model of Acute Ischemic Stroke

Dehkharghani

Mao

Howell

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE Applications for non-invasive biological temperature monitoring are widespread in biomedicine, and of particular interest in the context of brain temperature regulation, where traditionally costly and invasive monitoring schemes limit their applicability in many settings. Brain thermal regulation therefore remains controversial, motivating the development of non-invasive approaches such as temperature-sensitive NMR phenomena. The purpose of this work was to compare the utility of competing approaches to MR thermometry (MRT) employing proton resonance frequency chemical shift. Three methodologies were tested, hypothesizing the feasibility of a fast and accurate approach to chemical shift thermometry, in a phantom study at 3.0 Tesla. MATERIALS AND METHODS A conventional, paired approach (DIFF-1), an accelerated single-scan approach (DIFF-2), and a new, further accelerated strategy (DIFF-3) were tested. Phantom temperatures were modulated during real-time fiber optic temperature monitoring, with MRT derived simultaneously from temperature-sensitive changes in the water proton chemical shift (~0.01 ppm/°C). MRT was subsequently performed in a series of in vivo non-human primate experiments under physiologic and ischemic conditions testing its reproducibility and overall performance. RESULTS Chemical shift thermometry demonstrated excellent agreement with phantom temperatures for all three approaches (DIFF-1 linear regression R2=0.994, p<0.001, acquisition time 4 min 40 s; DIFF-2 R2=0.996, p<0.001, acquisition time 4 min; DIFF-3 R2=0.998, p<0.001, acquisition time 40 s). CONCLUSION These findings confirm the comparability in performance of three competing approaches MRT, and present in vivo applications under physiologic and ischemic conditions in a primate stroke model.

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Temperature gradient between brain tissue and arterial blood mirrors the flow‐metabolism relationship in uninjured brain: an experimental study

Abstract: The temperature difference between brain tissue and arterial blood DeltaT(br-a) mainly reflects the cerebral blood flow-brain tissue oxygenation-metabolism relationship as far as the estimation of the individual lower cerebral autoregulation threshold.

Cited by 12 publications

References 28 publications

Infrared Thermal Mapping, Analysis and Interpretation in Biomedicine

Infrared Thermal Mapping, Analysis and Interpretation in Biomedicine

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Proton Resonance Frequency Chemical Shift Thermometry: Experimental Design and Validation toward High-Resolution Noninvasive Temperature Monitoring and In Vivo Experience in a Nonhuman Primate Model of Acute Ischemic Stroke

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