Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization

Hesse, Janina; Schleimer, Jan-Hendrik; Maier, Nikolaus; Schmitz, Dietmar; Schreiber, Susanne

doi:10.1038/s41467-022-31195-6

Cited by 11 publications

(17 citation statements)

References 47 publications

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“…Introduction. -With the development of nonlinear physics and neuroscience, theoretical explanations to more and more complex electrical behaviors modulated by excitatory or inhibitory effects and related to brain functions or dysfunctions are awaited [1][2][3][4]. For example, seizure is often paralleled with the enhanced electrical activity of excitatory pyramidal neurons induced by the declining inhibitory effect of GABAergic interneuron [5].…”

Section: Copyright C 2023 Eplamentioning

confidence: 99%

Relationship between threshold and bifurcations for paradoxical firing responses along with seizure induced by inhibitory stimulation

Wang

Jia

2023

EPL

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Inhibition-induced enhancement or paradoxical response of firing was related to Hopf bifurcation instead of saddle-node bifurcation on an invariant cycle (SNIC), due to the ``negative" threshold and rotated vector fields. In the present Letter, by changing multiple parameters to adjust the vector fields, condition for the paradoxical response and ``negative" threshold is extended to SNIC near a codimension-2 bifurcation appearing prior to the Hopf bifurcation, which presents a comprehensive relationship between bifurcations and threshold. Especially, the result for a special current can well explain the enhanced firing along with seizure induced by inhibitory interneuron, implying that SNIC far from the codimension-2 bifurcation of pyramidal neuron is a potential candidate to avoid seizure.

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Section: Copyright C 2023 Eplamentioning

confidence: 99%

Relationship between threshold and bifurcations for paradoxical firing responses along with seizure induced by inhibitory stimulation

Wang

Jia

2023

EPL

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“…The spiking dynamics of biological neurons are a function of intrinsic neuron properties such as ion channel composition and morphology, and vary within as well as between cell types [1,2]. Additionally, spiking dynamics are subject to fluctuations in environmental parameters such as temperature [3], energy availability [4] and extracellular ion concentrations [5]. Moreover, spiking dynamics can be actively regulated through altered expression levels of ion channels [6].…”

Section: Introductionmentioning

confidence: 99%

Qualitative switches in single-neuron spike dynamics on neuromorphic hardware: implementation, impact on network synchronization and relevance for plasticity

Weerdmeester,

Niemeyer,

Pfeiffer

et al. 2024

Neuromorph. Comput. Eng.

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Most efforts on spike-based learning on neuromorphic hardware focus on synaptic plasticity and do not yet exploit the potential of altering the spike-generating dynamics themselves. Biological neurons show distinct mechanisms of spike generation, which affect single-neuron and network computations. Such a variety of spiking mechanisms can only be mimicked on chips with more advanced, nonlinear single-neuron dynamics than the commonly implemented leaky integrate-and-fire (LIF) neurons. Here, we demonstrate that neurons on the BrainScaleS-2 chip configured for exponential leaky integrate-and-fire (EIF) dynamics can be tuned to undergo a qualitative switch in spike generation via a modulation of the reset voltage. This switch is accompanied by altered synchronization properties of neurons in a network and thereby captures a main characteristic of the unfolding of the saddle-node loop (SNL) bifurcation - a qualitative transition that was recently demonstrated in biological neurons. Using this switch, cell-intrinsic properties alone provide a means to control whether small networks of all-to-all coupled neurons on the chip exhibit synchronized firing or splayed-out spiking patterns. We use an example from a central pattern generating circuit in the fruitfly to show that such dynamics can be induced and controlled on the chip. Our study thereby demonstrates the potential of neuromorphic chips with relatively complex and tunable single-neuron dynamics such as the BrainScaleS-2 chip, to generate computationally distinct single unit dynamics. We conclude with a discussion of the utility of versatile spike-generating mechanisms on neuromorphic chips.

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“…[1][2][3][4][5][6][7][8] These concepts play important roles in understanding brain functions and diseases, such as information coding, locomotion, and seizure. [9][10][11][12][13][14][15] The threshold is a basic conception to represent neuronal excitation property to external stimulation. Well known that a positive (or excitatory) stimulation beyond a threshold can elicit a spike, which has been widely accepted as common view.…”

Section: Introductionmentioning

confidence: 99%

Bifurcations for counterintuitive post-inhibitory rebound spike related to absence epilepsy and Parkinson disease

Wang

Jia

et al. 2023

Chinese Phys. B

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Seizures are caused by increased neuronal firing activity resulting from reduced inhibitory effect and enhancement of inhibitory modulation to suppress this activity is used as a therapeutic tool. However, recent experiments have shown a counterintuitive phenomenon that inhibitory modulation does not suppress but elicit post-inhibitory rebound (PIR) spike along with seizure to challenge the therapeutic tool. The nonlinear mechanism to avoid the PIR spike can present theoretical guidance to seizure treatment. This paper focuses on identifying credible bifurcations that underlie PIR spike by modulating multiple parameters in multiple theoretical models. The study identifies a codimension-2 bifurcation called Saddle-Node Homoclinic Orbit (SNHOB), which is an intersection between saddle node bifurcation on invariant cycle (SNIC) and other two bifurcations. PIR spike cannot be evoked for the SNIC far from the SNHOB but induced for the SNIC close to the SNHOB, which extends the bifurcation condition for PIR spike from the well-known Hopf to SNIC. Especially, in a thalamic neuron model, increases of conductance of T-type Ca2+ (TCa) channel induce SNIC bifurcation approaching to the SNHOB to elicit PIR spikes, closely matching experimental results of the absence seizure or Parkinson diseases. Such results imply that, when inhibition is employed to relieve absence seizure and Parkinson diseases related to PIR spike, modulating SNIC to get far from the SNHOB to avoid PIR spike is the principle. The study also addresses the complex roles of TCa current and comprehensive relationships between PIR spike and nonlinear conceptions such as bifurcation types and shapes of threshold curve.

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Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization

Cited by 11 publications

References 47 publications

Relationship between threshold and bifurcations for paradoxical firing responses along with seizure induced by inhibitory stimulation

Relationship between threshold and bifurcations for paradoxical firing responses along with seizure induced by inhibitory stimulation

Qualitative switches in single-neuron spike dynamics on neuromorphic hardware: implementation, impact on network synchronization and relevance for plasticity

Bifurcations for counterintuitive post-inhibitory rebound spike related to absence epilepsy and Parkinson disease

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