The aim of this work is to examine the thermohydric behavior of a building made of compressed stabilized earth bricks (CSEB), by testing its effectiveness in stabilizing the quality of indoor air, compared to four conventional materials. The study is carried out using TRNSYS-COMIS software with its Buffer Storage Humidity Model for three types of climates: desert, Mediterranean, and dry and cold semi-arid climate. The results highlight the contribution of the CSEB material in regulating the indoor relative humidity of buildings, also in limiting the effects of condensation thanks to its adsorption effect.