Temperature-dependent phagocytosis of highly branched poly(N-isopropyl acrylamide-co-1,2 propandiol-3-methacrylate)s prepared by RAFT polymerization

Hopkins, Sally A.; Carter, Stephen; Swanson, Linda; MacNeil, Sheila; Rimmer, Stephen

doi:10.1039/b708415c

Cited by 35 publications

(35 citation statements)

References 34 publications

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“…The synthesis of hyperbranched polymer has also been described for the encapsulation of drug or gene (siRNA). 102d-g, 358 Recently, CAMD 102d-e developed two different strategies for the synthesis of hyperbranched polymers built with disulfide bridges. The presence of disulfide bonds allows for a slow biodegradation of the hyperbranched structures.…”

Section: Stimuli-responsive Micelles/vesicles/starsmentioning

confidence: 99%

Bioapplications of RAFT Polymerization

et al. 2009

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His Ph.D. was in collaboration with Solvay-Solexis and devoted to the synthesis of new graft copolymers using grafting "to". In 2005, he undertook a postdoctorate position with Dupont Performance and Elastomers (Willmington, United States) and Dr. B. Ameduri dealing with the synthesis of original fluorinated elastomers using controlled radical polymerization (e.g., iodine transfer polymerization). Since October 2006, he has been a senior research fellow under the direction of Prof. Thomas Davis in the Centre of Advanced Macromolecular Design (CAMD), University of New South Wales. His research interests mainly cover the preparation of well-defined polymers, protein-polymer conjugates, and hybrid organic-inorganic nanoparticles using controlled radical polymerization. He has coauthored over 40 peer-reviewed research papers, including 2 book chapters, and 2 patents. Volga Bulmus received her B.E. and M.Sc. in Chemical Engineering and her Ph.D. in bioengineering (Hacettepe University, Turkey), in 2000. She worked as a postdoctoral research fellow in the Bioengineering Department at the University of Washington between 2001 and 2003. In 2004, she was granted a highly competitive The University of New South Wales (UNSW) Vice Chancellor's Research Fellowship (Australia). In 2008, she was appointed as a Senior Lecturer at the School of Biotechnology and Biomolecular Sciences (UNSW). She is also an adjunct member of The Centre for Advanced Macromolecular Design (CAMD) at UNSW. Dr. Bulmus leads a group of 5-10 researchers working on the development of advanced polymers for biotechnology and biomedical applications. She has published over 45 peer reviewed research papers. Her research interests include design, synthesis, and evaluation of well-defined polymeric systems for nanobiotechnology and drug delivery applications ranging from antitumor chemotherapy and gene silencing to bioseparations and biosensors. Tom Davis has been an academic at UNSW for 17 years following a stint in industry as a research manager at ICI in the U.K. He has coauthored 315+ reviewed papers, patents, and book chapters. He is the Director of the Centre for Advanced Macromolecular Design (CAMD) at UNSWsa Centre with expertise in bio/organic polymer synthesis and polymerization kinetics. He is also a visiting Professor at the Institute for Materials Research & Engineering (IMRE) in Singapore. In 2005 he was awarded a Federation Fellowship by the Australian Research Council. He serves (or has served) on the editorial advisory boards of Macromolecules,

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Section: Stimuli-responsive Micelles/vesicles/starsmentioning

confidence: 99%

Bioapplications of RAFT Polymerization

et al. 2009

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“…Hyperbranched polymers have potential uses in bio‐applications357 and surface coatings,358–360 and have been synthesized via conventional free radical copolymerization of monomers with difunctional monomers (used as cross‐linker) in the presence of thiols361–363 or in the presence of cobalt chain transfer (CCT) agents 364. The emergence of controlled radical polymerizations, such as ATRP, RAFT and NMP, has significantly extended the synthetic scope for generating hyperbranched structures, with improved control over the branching process as well as the overall molecular weight of the branched chains.…”

Section: Synthesis Of Well‐control Polymer Architecture Using Raft Pomentioning

confidence: 99%

Characterization and electrical properties of methyl‐2‐hydroxyethyl cellulose doped with erbium nitrate salt

El‐Kader

Said

El-Naggar

et al. 2006

J of Applied Polymer Sci

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X-ray diffraction, infrared (IR), and electrical properties for pure and Er (NO 3 ) 3 -doped methyl-2-hydroxyethyl cellulose (MHEC) with concentrations of 0.5, 1, 2, 5, 7, and 10 wt % were studied. X-ray analysis indicates that the addition of Er (NO 3 ) 3 , which is a crystalline material, to MHEC at concentrations 10 and 13 wt % leads to the formation of crystalline phases in the amorphous polymeric matrix. The appearance of the bending mode n 2 and the combination mode (n 1 þ n 4 ) of Er (NO 3 ) 3 in the IR spectra of composite samples indicates the coordination of nitro group in the chains of MHEC. From the I-V characteristics, it was found that the charge transport mechanism in MHEC appears to be essentially space charge limited conduction, while the predominant mechanism in the composite samples is Poole-Frenkel. Values of both drift mobility (m) and the charge carrier density (n) has been reported. The temperature dependence conductivity data has been analyzed in terms of the Arrhenius and Mott's variable range hopping models. Different Mott's parameters such as the density of states, N(E F ), hopping distance (R), and average hopping energy (W) have been evaluated.

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“…Changing the architecture to highly branched pNIPAAm continues the trend of using topology to modify properties. The resulting polymer exhibits a globular structure that can be exploited for controlled drug delivery, a subject of much current research 8–10. In addition to its globular structure, highly branched pNIPAAm also undergoes a thermal transition from hydrophilic to hydrophobic on reaching a critical temperature and can be used as a system to control drug delivery based on local temperature.…”

Section: Introductionmentioning

confidence: 99%

Cathepsin B cleavable novel prodrug Ac‐Phe‐Lys‐PABC‐ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis

Shao

Liu

Hou

et al. 2011

Cancer

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Highly branched “smart” polymers have emerged as a unique class of polymers with wide‐ranging applications. Poly(N‐isopropylacrylamide) (pNIPAAm) is at the forefront of stimuli‐responsive polymers; however, few transition temperature‐modification methods of linear pNIPAAm have been explored in highly branched systems. In this study, the three primary techniques of transition temperature modification of linear pNIPAAm are investigated for their efficacy on highly branched polymers. Of these techniques, cosolvent‐mediated tacticity control demonstrates an effect opposite of that which is expected. Temperature transition control via end‐group modification shows a marked decrease in efficacy in highly branched systems, despite highly branched systems having more end groups per polymer. Copolymerization with hydrophilic comonomers exhibits varying changes in efficacy compared to linear analogs, lending insights into the specific effects on the structured water surrounding the copolymer. While copolymerization proved to be most versatile in changing the transition temperature, all of the techniques showed interesting secondary effects. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013

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Temperature-dependent phagocytosis of highly branched poly(N-isopropyl acrylamide-co-1,2 propandiol-3-methacrylate)s prepared by RAFT polymerization

Cited by 35 publications

References 34 publications

Bioapplications of RAFT Polymerization

Bioapplications of RAFT Polymerization

Characterization and electrical properties of methyl‐2‐hydroxyethyl cellulose doped with erbium nitrate salt

Cathepsin B cleavable novel prodrug Ac‐Phe‐Lys‐PABC‐ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis

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