Temperature-dependent inhibition of evoked acetylcholine release in tick paralysis

Cooper, Benedict; Spence, Ian

doi:10.1038/263693a0

Cited by 81 publications

(48 citation statements)

References 8 publications

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“…In the case of paralysis in dogs caused by/. holocyclus, even a very small drop in body temperature may partially reverse the paralysis condition (Cooper and Spence, 1976;Stone, 1988).…”

Section: Discussionmentioning

confidence: 96%

The effect of feeding immature Karoo paralysis ticksIxodes rubicundus (Acari: Ixodidae) on the metabolic rate of the rock elephant shrew

Toit¹,

Fourie

1994

Exp Appl Acarol

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The effect of feeding immature Karoo paralysis ticks (Ixodes rubicundus) on the resting metabolic rate (RMR) of their principal natural host, the rock elephant shrew (Elephantulus myurus), was investigated under laboratory conditions. The elephant shrews were artificially infested with numbers of ticks simulating natural burdens. The RMR of the elephant shrews was quantified by measuring the oxygen consumption in an open through-flow system. The RMR of hosts infested only with larvae did not differ from that of the control group. Those infested with nymphs, or nymphs and larvae, had significantly lower RMR's compared to the control animals. There were no signs of paralysis in any of the infested hosts.

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“…In the case of paralysis in dogs caused by/. holocyclus, even a very small drop in body temperature may partially reverse the paralysis condition (Cooper and Spence, 1976;Stone, 1988).…”

Section: Discussionmentioning

confidence: 96%

The effect of feeding immature Karoo paralysis ticksIxodes rubicundus (Acari: Ixodidae) on the metabolic rate of the rock elephant shrew

Toit¹,

Fourie

1994

Exp Appl Acarol

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“…However, based on neurophysiological studies, it is thought most likely to act at the distal nerve ending, 3 although some evidence suggests possible effects at the neuromuscular junction. 4 Toxin production is likely related to feeding, as it takes approximately 5 days of feeding before the clinical effects of the neurotoxin are seen. 1 The diagnosis of tick paralysis is made with a thorough skin examination, performed based on recognition of the clinical presentation: an ascending fl accid paralysis.…”

Section: Discussionmentioning

confidence: 99%

A 4-Year-Old Boy with Ascending Weakness and a New ‘Skin Tag’

Hsieh¹,

Singh²,

Zecavati³

2011

Pediatr Ann

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“…In the Eastern USA, Dermacentor variabilis (American dog tick) is the most common culprit [34]. Salivary neurotoxins secreted during tick feeding impact presynaptic acetylcholine release [35,36], classically causing the onset of an ataxic gait followed by an acute ascending flaccid paralysis within a few days of tick attachment. As with some other types of ascending motor dysfunction, tick paralysis is associated with a relative sparing of sensation [6].…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Thoracic Arachnoid Cyst with Coexisting Tick Paralysis: Case Report and Review of the Literature

Foster¹,

Zwagerman²,

Ricks³

et al. 2013

Pediatr Neurosurg

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Tick paralysis is an uncommon phenomenon resulting from the release of a neurotoxin from the salivary glands of an engorged, gravid female tick about 5-7 days after attachment. The neurotoxin produces ascending weakness, mimicking other ascending paralytic processes. We present a case of a child presenting with weakness of the lower extremities and frequent falls who was found to have a compressive thoracic arachnoid cyst and a large distal syrinx. After surgical decompression, the patient made significant improvement in her leg strength, but quickly developed an ascending quadriparesis, followed by respiratory depression. Subsequent imaging and physical examination revealed an engorged tick embedded in her scalp. The tick was removed, and the patient made a rapid and complete clinical recovery. We present a unique case of concomitant tick paralysis and a symptomatic spinal intradural arachnoid cyst, and review the literature on tick paralysis.

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Temperature-dependent inhibition of evoked acetylcholine release in tick paralysis

Cited by 81 publications

References 8 publications

The effect of feeding immature Karoo paralysis ticksIxodes rubicundus (Acari: Ixodidae) on the metabolic rate of the rock elephant shrew

The effect of feeding immature Karoo paralysis ticksIxodes rubicundus (Acari: Ixodidae) on the metabolic rate of the rock elephant shrew

A 4-Year-Old Boy with Ascending Weakness and a New ‘Skin Tag’

Symptomatic Thoracic Arachnoid Cyst with Coexisting Tick Paralysis: Case Report and Review of the Literature

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