Temperature-dependent expression of turtleDmrt1 prior to sexual differentiation

Kettlewell, Jae R.; Raymond, Christopher S.; Zarkower, David

doi:10.1002/(sici)1526-968x(200003)26:3<174::aid-gene2>3.0.co;2-j

Cited by 191 publications

(23 citation statements)

References 21 publications

(23 reference statements)

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“…However, it is interesting to note that, in larvae reared at FPT, dmrt1 expression remained low throughout the experiment (See Additional file 1: Table S1), which opens the question on the function of dmrt1 in ovarian development in pejerrey [76]. Similar results have been reported in reptiles with TSD [30,77-79]. …”

Section: Reviewsupporting

confidence: 63%

Molecular players involved in temperature-dependent sex determination and sex differentiation in Teleost fish

Shen

Wang

2014

Genet Sel Evol

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The molecular mechanisms that underlie sex determination and differentiation are conserved and diversified. In fish species, temperature-dependent sex determination and differentiation seem to be ubiquitous and molecular players involved in these mechanisms may be conserved. Although how the ambient temperature transduces signals to the undifferentiated gonads remains to be elucidated, the genes downstream in the sex differentiation pathway are shared between sex-determining mechanisms. In this paper, we review recent advances on the molecular players that participate in the sex determination and differentiation in fish species, by putting emphasis on temperature-dependent sex determination and differentiation, which include temperature-dependent sex determination and genetic sex determination plus temperature effects. Application of temperature-dependent sex differentiation in farmed fish and the consequences of temperature-induced sex reversal are discussed.

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Section: Reviewsupporting

confidence: 63%

Molecular players involved in temperature-dependent sex determination and sex differentiation in Teleost fish

Shen

Wang

2014

Genet Sel Evol

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“…In humans, DMRT1 maps to the short arm of chromosome 9, and hemizygous deletion of this region is associated with defective testicular development (6,7). Dmrt1 has also been isolated in fish (8)(9)(10)(11)(12)(13), amphibians (14), reptiles (15), and marsupials (16), and Dmrt1 expression pattern in these species is consistent with a role in testis differentiation.…”

mentioning

confidence: 79%

The doublesex-related gene, XDmrt4 , is required for neurogenesis in the olfactory system

Huang

Hong

O’Donnell

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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The Dmrt genes encode a large family of transcription factors whose function in sexual development has been well studied. However, their expression pattern is not restricted to the gonad, suggesting that Dmrt genes might regulate other developmental processes. Here, we report the expression and functional analysis of one member of this family: Xenopus Dmrt4 (XDmrt4). XDmrt4 is initially expressed in the anterior neural ridge and then becomes progressively restricted to part of the telencephalon and the olfactory placode͞epithelium. XDmrt4 is induced at the anterior neural plate by a balance of neural inducers and caudalizing factors. Interference with XDmrt4 function by injection of a morpholino oligonucleotide or an inhibitory mutant resulted in a similar phenotype, the specific disruption of the olfactory placode expression of Xebf2 without affecting the expression of other placodal markers. Xebf2 belongs to a family of helix-loop-helix transcription factors implicated in neuronal differentiation, and later in embryogenesis XDmrt4-deficient embryos show impaired neurogenesis in the olfactory epithelium. Consistent with this finding, XDmrt4 is sufficient to activate neurogenin, Xebf2, and neural cell adhesion molecule expression in animal explants and is required for Noggin-mediated neuralization. Altogether, these results indicate that XDmrt4 is an important regulator of neurogenesis in the olfactory system upstream of neurogenin and Xebf2.placode ͉ Xenopus ͉ Xebf2 ͉ forebrain ͉ neurogenin G enes related to the Drosophila doublesex and Caenorhabditis elegans mab-3 genes encode transcription factors conserved during evolution (1). They constitute the Dmrt (doublesex and mab-3-related transcription factor) gene family, a class of molecules characterized by a signature zinc finger-like DNA-binding motif known as the DM domain (2).Dmrt genes have been shown to regulate sexual development in arthropods, nematodes, and vertebrates and, as such, represent a rare example of genes whose function in sex regulation has been highly conserved during evolution (3). Dmrt1 was the first DM domain gene identified in vertebrates (4). In the mouse, Dmrt1 is expressed in the genital ridge, and upon sexual differentiation its expression decreases in the ovary and is maintained in the testis (4). Mice with a targeted deletion of Dmrt1 show normal development in XX individuals, whereas genetically male individuals have severely hypoplastic testes (5). In humans, DMRT1 maps to the short arm of chromosome 9, and hemizygous deletion of this region is associated with defective testicular development (6, 7). Dmrt1 has also been isolated in fish (8-13), amphibians (14), reptiles (15), and marsupials (16), and Dmrt1 expression pattern in these species is consistent with a role in testis differentiation.There is accumulating evidence from different phyla that more than one Dmrt gene could be involved in sexual development. For example, Dmrt3, Dmrt5, and Dmrt7 also exhibit sexually dimorphic expression in the early embryonic gonad (17). Conv...

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“…In the temperature-dependent sex determination of alligators and turtles, DMRT1 exhibits the expected expression pattern for a sex-determining gene (19,33). In rainbow trout it has been shown that DMRT1 is expressed in the developing male gonad before morphological differentiation (15).…”

Section: Discussionmentioning

confidence: 99%

A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

Nanda

Kondo

Hornung

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

799

628

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The genes that determine the development of the male or female sex are known in Caenorhabditis elegans, Drosophila, and most mammals. In many other organisms the existence of sex-determining factors has been shown by genetic evidence but the genes are unknown. We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy of the autosomal DMRT1 gene, named DMRT1Y. This is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. The gene is expressed during male embryonic and larval development and in the Sertoli cells of the adult testes. These features make DMRT1Y a candidate for the medaka male sex-determining gene.

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Temperature-dependent expression of turtleDmrt1 prior to sexual differentiation

Cited by 191 publications

References 21 publications

Molecular players involved in temperature-dependent sex determination and sex differentiation in Teleost fish

Molecular players involved in temperature-dependent sex determination and sex differentiation in Teleost fish

The doublesex-related gene, XDmrt4 , is required for neurogenesis in the olfactory system

A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

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