Temperature dependent changes in cocaine- and amphetamine regulated transcript (CART) peptide in the brain of tadpole, Sylvirana temporalis

Shewale, Swapnil; Gaupale, Tekchand C.; Bhargava, S.

doi:10.1016/j.ygcen.2014.06.025

Cited by 8 publications

(1 citation statement)

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“…Both CART precursors have been reported to be abundantly expressed in brain, pituitary and also in other peripheral tissues such as eye, interrenal tissues, and gonads in goldfish (39). CART exerts multiple physiological functions in fish, including the inhibition of appetite (39), regulation of the stress response (40) and energy balance (41).…”

Section: Hormones Regulating Food Intakementioning

confidence: 99%

Nutrient Regulation of Endocrine Factors Influencing Feeding and Growth in Fish

et al. 2019

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Endocrine factors regulate food intake and growth, two interlinked physiological processes critical for the proper development of organisms. Somatic growth is mainly regulated by growth hormone (GH) and insulin-like growth factors I and II (IGF-I and IGF-II) that act on target tissues, including muscle, and bones. Peptidyl hormones produced from the brain and peripheral tissues regulate feeding to meet metabolic demands. The GH-IGF system and hormones regulating appetite are regulated by both internal (indicating the metabolic status of the organism) and external (environmental) signals. Among the external signals, the most notable are diet availability and diet composition. Macronutrients and micronutrients act on several hormone-producing tissues to regulate the synthesis and secretion of appetite-regulating hormones and hormones of the GH-IGF system, eventually modulating growth and food intake. A comprehensive understanding of how nutrients regulate hormones is essential to design diet formulations that better modulate endogenous factors for the benefit of aquaculture to increase yield. This review will discuss the current knowledge on nutritional regulation of hormones modulating growth and food intake in fish.

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Section: Hormones Regulating Food Intakementioning

confidence: 99%

Nutrient Regulation of Endocrine Factors Influencing Feeding and Growth in Fish

et al. 2019

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One evidence of cocaine- and amphetamine-regulated transcript (CART) has the bidirectional effects on appetite in Siberian sturgeon (Acipenser baerii)

Zhang

Gao

Tang

et al. 2017

Fish Physiol Biochem

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Cocaine- and amphetamine-regulated transcript (CART), discovered in 1995, with various biological functions, has received much attention recently due to its role in the regulation of appetite in mammals. However, the function of CART on the appetite control in fish species is still not very clear. In this study, Siberian sturgeon (Acipenser baerii Brandt) cart gene was cloned for the first time, and the cart mRNA levels in 11 feeding-related tissues was investigated. The Siberian sturgeon cart gene sequence was 1459 base pairs (bp), including a 3'-terminal untranslated region (3'-UTR) of 39 bp, a 5'-terminal untranslated region (5'-UTR) of 52 bp, and an open reading frame (ORF) of 348 bp encoding 115 amino acids. Siberian sturgeon cart gene has three exons and two introns including 341 bp intron 1 and 679 bp intron 2. The result of tissue distribution showed that cart was widely distributed in 11 tissues with the highest expression in the whole brain. The effects of periprandial (pre- and post-feeding), fasting, and re-feeding on cart mRNA abundance in the whole brain were assessed. Periprandial result showed the expression of cart mRNA in the whole brain significantly elevated after feeding for 3 h. However, fasting experiment showed that the level of cart significantly decreased after 1 day of fasting, but that significantly increased after 3-17 days of food deprivation and returned to the basic level after 3 days of re-feeding in the fishes which were fasted for 15 days. In conclusion, this study suggests that CART has the bidirectional effects on appetite, which acts as a satiety factor in short-term feeding regulation but as a starvation factor in long-term appetite regulation in Siberian sturgeon.

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