The aim of this work is to complete our studies on physical properties of binary mixtures of alkane + 1-alkanols. This work reports densities, refractive indices, speeds of sound, and isentropic compressibilities of the mixture of hexane with 1-hexanol at different temperatures, from 288.15 K to 308.15 K. From the experimental values, the corresponding excess and deviation values were computed (excess molar volumes, changes of refractive index upon mixing, changes of speed of sound upon mixing, and changes of isentropic compressibilities upon mixing). Variable-degree polynomials were fitted to the results. A comparative study of these results with other available physical properties of the same mixture was performed. Excess molar volumes were compared with the predictions of the Nitta-Chao Group contribution model.