Temperature course in small volume [18O]water targets for [18F]F− production

A Target-Temperature Monitoring System for Cyclotron Targets: Safety Device and Tool to Experimentally Validate Targetry Studies

“…Figure 1 also shows that although the temperature of the refrigerated water only stabilizes after a long period (due to slow thermal stabilization in the different vast sub-systems cyclotron; such as coils of the magnetic field, radiofrequency structure, etc. ), rising temperature occurs and stabilizes instantaneously in the target and the collimator, as already reported by Steinbach et al [14]. Moreover, Figure 1 indicates that the temperature increments seem to be almost independent of the refrigerated water temperature since these are nearly constant during the irradiation.…”

Facile calculation of specific rate constants and activation energies of 18F-fluorination reaction using combined processes of coat-capture–elution and microfluidics

“…2 Most 18 F-labeling reactions are nucleophilic substitution using [ 18 F]fluoride produced by bombardment of [ 18 O]water with accelerated proton. 3,4 Generally, [ 18 F]fluoride is captured on an anion exchange resin and then eluted with base solution such as K 2 CO 3 / Kryptofix 2.2.2 (K222) or tetrabutylammonium bicarbonate (TBAB) (Fig. 1a).…”

Convenient recycling and reuse of bombarded [ 18 O]H 2 O for the production and the application of [ 18 F]F −

“…Many factors during the bombardment influence the production activities, e.g. thermodynamic effects as previously discovered (Steinbach et al, 1990 (Fig. 4A) or in the spectra of other radionuclides (Fig.…”