Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination

Garanina, Anastasiia S.; Naumenko, Victor; Никитин, А. А.; Myrovali, Eirini; Petukhova, Anna Y.; Klimyuk, Svetlana V.; Nalench, Yulia A; Ilyasov, Artem; Vodopyanov, Stepan S.; Erofeev, Alexander; Gorelkin, Peter; Angelakeris, Makis; Savchenko, Alexander; Wiedwald, Ulf; Majouga, Alexander G.; Abakumov, Maxim

doi:10.1016/j.nano.2020.102171

Cited by 57 publications

(42 citation statements)

References 47 publications

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“…Not only is drug combination necessary, but therapy combination too, ideally localized at the target site and possibly by using the same platform for a simultaneous application of several therapies. In the context of cancer, this is especially relevant because all the most consolidated therapies (surgery, radiotherapy, chemotherapy, and photodynamic therapy) are not fully effective, especially chemo- and radiotherapy, which provoke severe side effects due to their lack of specificity [ 3 ]. For this reason, alternative strategies are becoming attractive, and among them, magnetic hyperthermia (MH) is one of the most promising [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

et al. 2020

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The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

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Section: Introductionmentioning

confidence: 99%

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

et al. 2020

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“…Finally, a step forward is to use the same nanoplatform as nanocarrier and as a magnetic hyperthermia agent to enhance the cytotoxic effect of chemotherapy with hyperthermia. Indeed, it is well known that magnetic nanoparticles exposed to an AMF develop heat, thus selectively killing tumor cells which are more sensitive than normal cells to high temperatures in the range of 43–46 °C [ 3 , 77 ]. Such a potential application was first tested in in vitro experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Although substantial advancements in therapy have been reached with surgery, chemotherapy, radiotherapy, and immunotherapy, there are still many drawbacks that require novel approaches [ 1 , 2 ]. Chemotherapy is the most common treatment for the majority of tumors, although its limited specificity toward cancer targets is responsible for important severe side effects [ 3 , 4 , 5 ]. The anthracycline Doxorubicin (DOXO) is one of the most effective chemotherapeutics used for treatment of solid tumors and, in particular, breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Magnetite Nanoparticles as Targeted Drug Nanocarriers and Mediators of Hyperthermia in an Experimental Cancer Model

Oltolina

Peigneux

Colangelo

et al. 2020

Cancers

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Biomimetic magnetic nanoparticles mediated by magnetosome proteins (BMNPs) are potential innovative tools for cancer therapy since, besides being multifunctional platforms, they can be manipulated by an external gradient magnetic field (GMF) and/or an alternating magnetic field (AMF), mediating targeting and hyperthermia, respectively. We evaluated the cytocompatibility/cytotoxicity of BMNPs and Doxorubicin (DOXO)-BMNPs in the presence/absence of GMF in 4T1 and MCF-7 cells as well as their cellular uptake. We analyzed the biocompatibility and in vivo distribution of BMNPs as well as the effect of DOXO-BMNPs in BALB/c mice bearing 4T1 induced mammary carcinomas after applying GMF and AMF. Results: GMF enhanced the cell uptake of both BMNPs and DOXO-BMNPs and the cytotoxicity of DOXO-BMNPs. BMNPs were biocompatible when injected intravenously in BALB/c mice. The application of GMF on 4T1 tumors after each of the repeated (6×) iv administrations of DOXO-BMNPs enhanced tumor growth inhibition when compared to any other treatment, including that with soluble DOXO. Moreover, injection of DOXO-BMNPs in the tumor combined with application of an AMF resulted in a significant tumor weight reduction. These promising results show the suitability of BMNPs as magnetic nanocarriers for local targeted chemotherapy and as local agents for hyperthermia.

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“…Additionally, MNPs have also been used as nanocarriers, where the use of a magnetic field might result in accumulation in a particular spot in the organism. Furthermore, by using an alternating magnetic field these MNPs may act as "heat-converters", assisting strategies relying on mild hyperthermia (42-45 • C), which have been shown to improve gene delivery efficiency through the cell compartments, enhancing gene silencing effects [87][88][89][90].…”

Section: Metal Nps For Gene Silencingmentioning

confidence: 99%

Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics

et al. 2020

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Cancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhance therapy success. Among these nanomedicines, nanoparticle mediated delivery of nucleic acids has been put forward as key instrument to modulate gene expression, be it targeted gene silencing, interference RNA mechanisms and/or gene edition. These novel delivery systems have strongly relied on nanoparticles and, in particular, gold nanoparticles (AuNPs) have paved the way for efficient delivery systems due to the possibility to fine-tune their size, shape and surface properties, coupled to the ease of functionalization with different biomolecules. Herein, we shall address the different molecular tools for modulation of expression of oncogenes and tumor suppressor genes and discuss the state-of-the-art of AuNP functionalization for nucleic acid delivery both in vitro and in vivo models. Furthermore, we shall highlight the clinical applications of these spherical AuNP based conjugates for gene delivery, current challenges, and future perspectives in nanomedicine.

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Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination

Cited by 57 publications

References 47 publications

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Biomimetic Magnetite Nanoparticles as Targeted Drug Nanocarriers and Mediators of Hyperthermia in an Experimental Cancer Model

Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics

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