Temperature controlled encapsulation and release using partially biodegradable thermo-magneto-sensitive self-rolling tubes

Zakharchenko, Svetlana; Puretskiy, Nikolay; Stoychev, Georgi; Stamm, Manfred; Ionov, Leonid

doi:10.1039/c0sm00088d

Cited by 143 publications

(158 citation statements)

References 23 publications

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“…An interesting use of thermoresponsive polymer films was shown by Zakharchenko et al where a bilayer of PVCL on top of PNIPAAm with encapsulated magnetic nanoparticles was prepared [128]. At temperatures greater than the LCST the films were flat and allowed for adsorption of nanoparticles, cells or drugs onto the surface, Figure 9, upon cooling the films rolled up entrapping the absorbed particles which could then be release by heating again [128].…”

Section: Filmsmentioning

confidence: 99%

“…At temperatures greater than the LCST the films were flat and allowed for adsorption of nanoparticles, cells or drugs onto the surface, Figure 9, upon cooling the films rolled up entrapping the absorbed particles which could then be release by heating again [128]. This is a novel approach for the encapsulation and release of nanoparticles and cells with the addition of the magnetic particles allowing manipulation of the films by an external field [128].…”

Section: Filmsmentioning

confidence: 99%

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Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Filmsmentioning

confidence: 99%

Section: Filmsmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…At temperatures greater than the lower critical solution temperature (LCST) the films were flat and allowed for adsorption of nanoparticles, cells or drugs onto the surface, upon cooling the films rolled up entrapping the absorbed particles which could then be released by heating again. This is a novel approach for the encapsulation and release of nanoparticles and cells with the addition of the magnetic particles allowing manipulation of the films by an external field [31]. Some of the IPN based films with their applications are shown in Table 1.…”

Section: Features Of Ipnmentioning

confidence: 99%

Biomedical Applications of Interpenetrating Polymer Network System

Qadri¹,

Malviya²,

Sharma³

2015

PHARMSCI

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Abstract:Interpenetrating polymer network (IPN) has been regarded as one of the novel technology in recent years showing the superior performances over the conventional techniques. This system is designed for the delivery of drugs at a predetermined rate and thus helps in controlled drug delivery. Due to its enhanced biological and physical characteristics like biodegradability, biocompatibility, solubility, specificity and stability, IPN has emerged out to be one of the excellent technologies in pharmaceutical industries. This article focuses mainly on the biomedical applications of IPN along with its future applicability in pharmaceutical research. It summarizes various aspects of IPN, biomedical applications and also includes the different dosage forms based on IPN.

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“…For instance, in semiconductor epitaxially grown heterofilms, the strain is provoked by the mismatch of the crystal lattice constants of the top and bottom layers [4][5][6][7]. In polymer multi-layer films, curling can be triggered by an unequal swelling ratio of the top and bottom layers in a given solvent [8][9][10][11][12]. For instance, polystyrene/poly(4-vinyl pyridine) bilayer films roll up in acidic water due to preferential swelling of the P4VP layer [8].…”

Section: Introductionmentioning

confidence: 99%

Photochemistry for Advanced Nanoengineering: Polymer Microtubes with Inner Walls Coated with Silver Nanoparticles

Luchnikov

Balan

2014

Nanomaterials and Nanotechnology

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Micro-capillaries with an engineered hidden surface were produced via the self-rolling of polymer thin films whose surface was photochemically modified so as to coat it with silver nanoparticles. The polymer films consisted of a poly(4-vinyl pyridine) (P4VP) layer topcoated with a polystyrene layer. When immersed in acid water, they underwent self-rolling due to selective swelling of the poly(4-vinyl pyridine) layer. The generation of Ag nanoparticles at the inner structure of the 40 µm-wide capillaries was carried out by a photochemically initiated reduction process. It was confirmed by UV-VIS spectroscopy, transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDX) analysis. The possibility of designing non-uniform distributions of silver particles at the inner surface of the tubes was also established. It consists of photopatterning the top of the film -the polystyrene side -prior to the swelling/selfrolling step. This approach provides new opportunities for the design of micro-compartments for micro-biological research and for micro-fluidics applications.

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Temperature controlled encapsulation and release using partially biodegradable thermo-magneto-sensitive self-rolling tubes

Abstract: † Electronic supplementary information (ESI) available: Movies of tube formation, particle capture by rolling tubes, reversible encapsulation and release of particles and flow of particle-loaded tubes in a magnetic field.

Cited by 143 publications

References 23 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

Biomedical Applications of Interpenetrating Polymer Network System

Photochemistry for Advanced Nanoengineering: Polymer Microtubes with Inner Walls Coated with Silver Nanoparticles

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