Temperature controlled camptothecin release from biodegradable magnetic PLGA microspheres

Zahn, Diana; Weidner, Andreas; Nosrati, Zeynab; Wöckel, Lucas; Dellith, Jan; Müller, Robert N.; Saatchi, Katayoun; Häfeli, Urs O.; Dutz, Silvio

doi:10.1016/j.jmmm.2018.09.011

Cited by 8 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These can be actively guided to a target location and then thermally activated using hyperthermia to increase the drug and nanoparticle release. This process can again be monitored using the difference in the MPI signal of incorporated and free magnetic nanoparticles. , Also possible is the application in the inner ear for targeted drug delivery . Another application scenario includes the guidance of AMM into vessel branches with occlusions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Selective Actuation and Tomographic Imaging of Swarming Magnetite Nanoparticles

Bente

Bakenecker

Gladiss

et al. 2021

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Micro- and nanomotors have seen substantial progress in recent years for biomedical applications. However, three grand challenges remain: (i) high velocities to overcome the blood flow, (ii) spatially selective control to enable complex navigation, and (iii) integration of a medical, tomographic real-time imaging method to acquire feedback information. Here, we report the combination of active magnetic matter and a medical imaging technique, namely magnetic particle imaging (MPI), which addresses these needs. We synthesize ∼200 nm magnetic nanoparticles and observe a macroscopic, collective effect in a homogeneous magnetic field with a rotating field vector. The nanoparticles form a millimeter-sized cloud and reach speeds of 8 mm s–1. This cloud is imaged and selectively steered with an MPI scanner. Our experimental results are supported by a model that highlights the role of the Mason number, the particle’s volume fraction, and the height of the cloud. The successful introduction of a fast swarm of microscopic units and the spatial selectivity of the technique suggest an effective approach to translate the use of micro- and nanobots into a clinical application.

show abstract

Section: Discussionmentioning

confidence: 99%

“…This process can again be monitored using the difference in the MPI signal of incorporated and free magnetic nanoparticles. 43,44 Also possible is the application in the inner ear for targeted drug delivery. 45 Another application scenario includes the guidance of AMM into vessel branches with occlusions.…”

Section: ■ Discussion and Conclusionmentioning

confidence: 99%

Selective Actuation and Tomographic Imaging of Swarming Magnetite Nanoparticles

Bente

Bakenecker

Gladiss

et al. 2021

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…This study and another using citric acid-modified magnetic nanoparticles incorporated into DOX-containing liposomes showed feasibility of using external magnetic fields to spatiotemporally control drug release, building off of the earlier work that used non-MH induction sources 109 . Additional drug carriers have since been developed to improve uptake by tumor cells 110 , release other chemotherapeutic drugs 111 , 112 , or use differing heat-triggered release mechanisms 113 .…”

Section: Magnetic Systemsmentioning

confidence: 99%

Magnetic systems for cancer immunotherapy

Day

Wixson

Shields

2021

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors. Magnetic systems offer several advantages for improving the performance of immunotherapies, including increased spatiotemporal control over transport, release, and dosing of immunomodulatory drugs within the body, resulting in reduced off-target effects and improved efficacy. Compared to alternative methods for stimulating drug release such as light and pH, magnetic systems enable several distinct methods for programming immune responses. First, we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug release. Second, we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target sites. Third, we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated drugs. Fourth, we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor activity. Finally, we discuss translational considerations of these systems, such as toxicity, clinical compatibility, and future opportunities for improving cancer treatment.

show abstract

“…7 Hariri et al 8 investigated the targeted delivery of PTX and CMPT from a cross-linked sponge against lung cancer. The use of targeted drug delivery systems such as liposomes, 9,10 microspheres, 11,12 nanoparticles, 13,14 and nanobers [15][16][17][18] could provide the sustained delivery of anticancer drugs. k-Carrageenan, an anionic sulfonated polysaccharide, is extracted from red algae and used for biomedical applications such as food, tissue engineering and drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%