Temperature Control Function of the Choroid May Be the Reason for the Increase in Choroidal Thickness during the Acute Phase of Familial Mediterranean Fever

Kaya, Abdullah; Aksoy, Yakup; Sevinc, Mehmet Koray; Diner, Oktay

doi:10.1159/000443849

Cited by 2 publications

(4 citation statements)

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“…If they project to the same ventrocaudal part of the spinal trigeminal nucleus as the corneal sensory fibers, then the choroidal sensory fibers could mediate choroidal vasodilation in response to thermal signals or inflammatory signals. In this light, choroidal thickening during viral fever is of interest, since it could be driven by either the thermal signals or inflammatory signals caused by the viral illness (Kaya et al, 2016). Note also that Gallar et al (2003) reported the presence of cold sensing scleral and episcleral fibers at the back of the eye in cats and noted that these fibers respond to cooling associated with experimentally diminished choroidal blood flow.…”

Section: Trigeminal Sensory Input To Choroidmentioning

confidence: 99%

Neural control of choroidal blood flow

Reiner

Fitzgerald

Mar

et al. 2018

Progress in Retinal and Eye Research

148

128

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The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow. As the choroid lies behind the retina and cannot respond readily to retinal metabolic signals, its innervation is important for adjustments in flow required by either retinal activity, by fluctuations in the systemic blood pressure driving choroidal perfusion, and possibly by retinal temperature. The former two appear to be mediated by the sympathetic and parasympathetic nervous systems, via central circuits responsive to retinal activity and systemic blood pressure, but adjustments for ocular perfusion pressure also appear to be influenced by local autoregulatory myogenic mechanisms. Adaptive choroidal responses to temperature may be mediated by trigeminal sensory fibers. Impairments in the neural control of choroidal blood flow occur with aging, and various ocular or systemic diseases such as glaucoma, age-related macular degeneration (AMD), hypertension, and diabetes, and may contribute to retinal pathology and dysfunction in these conditions, or in the case of AMD be a precondition. The present manuscript reviews findings in birds and mammals that contribute to the above-summarized understanding of the roles of the autonomic and sensory innervation of the choroid in controlling choroidal blood flow, and in the importance of such regulation for maintaining retinal health.

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Section: Trigeminal Sensory Input To Choroidmentioning

confidence: 99%

Neural control of choroidal blood flow

Reiner

Fitzgerald

Mar

et al. 2018

Progress in Retinal and Eye Research

148

128

View full text Add to dashboard Cite

show abstract

“…We read Kaya et al's comments [1] on our article entitled ‘Choroidal Thickness Changes in the Acute Attack Period in Patients with Familial Mediterranean Fever' [2] with great interest. Kaya et al [1] assert that there is no evidence of inflammation in the choroid during the acute phase of familial Mediterranean fever (FMF).…”

mentioning

confidence: 99%

“…Kaya et al [1] assert that there is no evidence of inflammation in the choroid during the acute phase of familial Mediterranean fever (FMF). The authors claim that if an inflammation was present, a uveitic presentation like Vogt-Koyanagi-Harada disease would be seen in the patients.…”

mentioning

confidence: 99%

“…Another important point is that not all inflammatory conditions of choroid have funduscopic findings, even Vogt-Koyanagi-Harada disease [5,6]. Kaya et al [1] hypothesized that the cause of increase in choroidal thickness may be the temperature control function of the choroid. As mentioned in the methods section of our study [2], body temperature of all patients was within normal limits.…”

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confidence: 99%

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