Temperature and pH‐response swelling behavior of poly(2‐ethyl‐2‐oxazoline)/chitosan interpenetrating polymer network hydrogels

Abstract

ABSTRACT:Interpenetrating polymer network (IPN) hydrogels composed of poly(2-ethyl-2-oxazoline) (PEtOz) and chitosan (CS) were prepared with radical polymerization and were characterized for their swelling properties. Sample OC11 (hydrogel weight ratio PEtOz/CS ϭ 1/1) swelled more than samples OC21 (PEtOz/CS ϭ 2/1) and OC31 (PEtOz/CS ϭ3/1), exhibiting a swelling ratio of about 2000 wt % in deionized water; the swelling ratios of the other samples were about 1000 and 700 wt %. The swelling behavior of the IPN hydrogels was observed under various pH and temperature conditions. The swelling ratios of the samples ranged from about 2000 to 6500 wt % at lower pHs, with a maximum swelling ratio of about 6500 wt % in a pH 2 aqueous solution. They exhibited low critical solution temperature behavior, with sample OC31 more sensitive to temperature and sample OC11 more sensitive to pH.

Bioinspired Poly(2-oxazoline)s

“…These hydrogels exhibited reversible swelling-deswelling behavior upon step-wise change of temperature from 20 to 70 °C. Similarly, Kim reported reversible temperature-induced swelling-deswelling cycles for interpenetrating network hydrogels of cross-linked PEtOx macromonomer with poly(vinyl alcohol) (PVA) [41] or chitosan [42]. Albertson et al reported the synthesis and swelling behavior of ternary microgel particles consisting of PNIPAM, PHEMA, and PMeOx or PEtOx [43].…”

Preparation of Carbopol/chitosan interpolymer complex as a controlled release tablet matrix; effect of complex formation medium on drug release characteristics

“…The hydrogel in a swollen state maintains a soft and rubbery state comparable to living tissues and displays excellent biocompatibility (Ju et al, 2002). Among various hydrogels, chitosan-based hydrogels have been the focus of study by many investigators (Kim et al, 2006;Ahn et al, 2002) due to its relatively high biocompatibility and ability to be cross-linked, thereby rendering a threedimensional network structure to it. The network structure prevents a dosage form from dissolving easily in the medium, and the extended drug release from the swollen gel structure can thus be achieved.…”

“…Among various polymers, hydrogels have been widely used in the development of various controlled release matrix tablets (Kim et al, 2006;Noble et al, 1999). The hydrogel in a swollen state maintains a soft and rubbery state comparable to living tissues and displays excellent biocompatibility (Ju et al, 2002).…”

Poly(2‐oxazoline): eine Polymerklasse mit vielfältigen Anwendungsmöglichkeiten

“…[37] Interessanterweise ermöglichte die Kontrolle der Triblockcopolymer-Zusammensetzung die Absenkung des [77] oder Chitosan. [78] In einer neueren Untersuchung berichteten David et al über die Synthese und das Quellungsverhalten ternärer Mikrogelpartikel, die aus NIPAM, HEMA und PMeOx-oder PEtOx-Makromonomeren bestehen. [79] Beim…”