Temperature and pH dependent solubility of novel poly(N-isopropylacrylamide)-copolymers

Kuckling, Dirk; Adler, Hans-Jürgen P.; Arndt, Karl‐Friedrich; Ling, Liansheng; Habicher, Wolf D.

doi:10.1002/(sici)1521-3935(20000201)201:2<273::aid-macp273>3.0.co;2-e

Cited by 146 publications

(42 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the temperature increases from 10 to 50 8C, an endothermal peak appears at 31.26 8C with an enthalpy of 1.06 J Á g À1 , which is similar to the LCST of pure PNIPAM. [1] Correspondingly, an associated exothermal peak with an enthalpy of 1.19 J Á g À1 at 27.46 8C appeared as the temperature decreased from 50 to 10 8C. This phenomenon may be caused by the result of competition between intermolecular and intramolecular hydrogen bonding below and above the LCST.…”

Section: Resultsmentioning

confidence: 99%

“…[1] The inverse solubility-temperature relationship of this polymer in water results in the phase separation of PNIPAM solutions above the lower critical solution temperature (LCST) and thus PNIPAM is considered to be hydrophilic below the LCST or hydrophobic above the LCST. For PNIPAM in pure water, the LCST is 32 8C.…”

Section: Introductionmentioning

confidence: 97%

“…For PNIPAM in pure water, the LCST is 32 8C. [1] PNIPAM-based polymers and derivatives are being exploited in sensors, responsive membranes, drug-delivery vehicles, and anti-fouling surfaces. [2][3][4][5] Nanotubes have been widely investigated due to their special properties and exciting potential applications in optical, electronic, magnetic, and thermosensitive devices.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of Thermosensitive PNIPAM‐co‐MBAA Nanotubes by Atom Transfer Radical Polymerization within a Porous Membrane

Cui

Cheng

Zheng

et al. 2005

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Summary: Thermosensitive polymer nanotubes can be fabricated within an aminopropylsilane‐modified porous anodic aluminum oxide membrane by surface‐initiated atom transfer radical polymerization (ATRP) followed by template removal. DSC experiments prove that the synthesized PNIPAM‐co‐MBAA copolymer nanotubes have a reversible thermosensitive behavior. The temperature‐induced changes in dimension and shape of the nanotubes were studied by AFM in real time in an aqueous environment. It indicates that the nanotubes undergo a shape alteration from an “ellipse” to “circular” shape in water upon heating to LCST or above.DSC curves of PNIPAM‐co‐MBAA nanotubes.magnified imageDSC curves of PNIPAM‐co‐MBAA nanotubes.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of Thermosensitive PNIPAM‐co‐MBAA Nanotubes by Atom Transfer Radical Polymerization within a Porous Membrane

Cui

Cheng

Zheng

et al. 2005

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…[35,36] It is well known that combining PNiPAAm with hydrophilic groups increases the T c . [37][38][39] This has to be considered when glycomonomers are combined with PNiPAAm forming block or random copolymers aiming to increase biocompatibility. [40,41] However, copolymers of PNiPAAm and glycomonomers are very interesting materials for polymeric scaffolds in tissue engineering and for biocompatible and bioactive coatings for cell cultures, medical tools and implants which makes it necessary to adjust T c carefully.…”

Section: Full Papermentioning

confidence: 99%

Thermoresponsive Glycopolymers via Controlled Radical Polymerization

Özyürek

Komber

Gramm

et al. 2007

Macro Chemistry & Physics

View full text Add to dashboard Cite

New glycomonomers 3′‐(1′,2′:5′,6′‐di‐O‐isopropylidene‐α‐D‐glucofuranosyl)‐6‐methacrylamido hexanoate (MAIpGlcC5) and 3′‐(1′,2′:5′,6′‐di‐O‐isopropylidene‐α‐D‐glucofuranosyl)‐6‐methacrylamido undecanoate (MAIpGlcC10) with hydrophobic spacer units were synthesized and their homopolymers, as well as random copolymers with N‐isopropylacrylamide (NiPAAm) were prepared in varying compositions. The acidolysis of the isopropylidene protection groups of the polymers gave well‐defined sugar‐containing water‐soluble homopolymers (PMAGlcCn, n = 5, 10) and copolymers. By using the reversible addition–fragmentation chain transfer (RAFT) process, it was possible to afford these copolymers with a polydispersity index (PDI) of 1.1–1.5. Furthermore, NiPAAm homopolymers with an active chain transfer unit at the chain end could be prepared by RAFT, which were used as macro‐chain transfer agents (macro‐CTAs) to prepare a variety of sugar containing responsive block copolymers from new glycomonomers by the monomer addition concept. The cloud points of the aqueous solutions of the copolymers were strongly affected by the comonomer content, spacer chain length of the glycomonomer, and the chain architecture of the copolymers. Especially by the block copolymer concept, glycopolymers with lower critical solution temperatures (LCSTs) in the physiologically interesting range could be realized.magnified image

show abstract

“…However, the LCST of the PNIPAM polymer is below the physiological temperature which limits the drug delivery application of these polymers as the drug is released as soon as it is injected into the blood stream, preventing delivery to the targeted sites. Recently, it was shown that the LCST of PNIPAM could be controlled by including hydrophilic units (to increase the LCST) or hydrophobic residues (to lower the LCST) (12,13). Thus, Richard et al (14) have studied the tunability of LCST of poly (2-oxazoline)s by varying its composition and molecular weight.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

2014

View full text Add to dashboard Cite

Abstract. Herein, we report the successful development of a novel nanosystem capable of an efficient delivery and temperature-triggered drug release specifically aimed at cancer. The water-soluble 130.1±0.2 nm iron oxide nanoparticles (IONPs) were obtained via synthesis of a monodispersed iron oxide core stabilized with tetramethylammonium hydroxide pentahydrate (TMAOH), followed by coating with the thermoresponsive copolymer poly-(NIPAM-stat-AAm)-block-PEI (PNAP). The PNAP layer on the surface of the IONP undergoes reversible temperature-dependent structural changes from a swollen to a collapsed state resulting in the controlled release of anticancer drugs loaded in the delivery vehicle. We demonstrated that the phase transition temperature of the prepared copolymer can be precisely tuned to the desired value in the range of 36°C-44°C by changing the monomers ratio during the preparation of the nanoparticles. Evidence of modification of the IONPs with the thermoresponsive copolymer is proven by ATR-FTIR and a quantitative analysis of the polymeric and iron oxide content obtained by thermogravimetric analysis. When loaded with doxorubicin (DOX), the IONPs-PNAP revealed a triggered drug release at a temperature that is a few degrees higher than the phase transition temperature of a copolymer. Furthermore, an in vitro study demonstrated an efficient internalization of the nanoparticles into the cancer cells and showed that the drugfree IONPs-PNAP were nontoxic toward the cells. In contrast, sufficient therapeutic effect was observed for the DOX-loaded nanosystem as a function of temperature. Thus, the developed temperature-tunable IONPsbased delivery system showed high potential for remotely triggered drug delivery and the eradication of cancer cells.

show abstract

Temperature and pH dependent solubility of novel poly(N-isopropylacrylamide)-copolymers

Cited by 146 publications

References 19 publications

Synthesis of Thermosensitive PNIPAM‐co‐MBAA Nanotubes by Atom Transfer Radical Polymerization within a Porous Membrane

Synthesis of Thermosensitive PNIPAM‐co‐MBAA Nanotubes by Atom Transfer Radical Polymerization within a Porous Membrane

Thermoresponsive Glycopolymers via Controlled Radical Polymerization

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

Contact Info

Product

Resources

About