Temperature and pH dependent solubility of novel poly(N-isopropylacrylamide)-copolymers

Kuckling, Dirk; Adler, Hans-Jürgen P.; Arndt, Karl‐Friedrich; Лонг, Линг; Habicher, Wolf D.

doi:10.1002/(sici)1521-3935(20000201)201:2<273::aid-macp273>3.3.co;2-5

Cited by 51 publications

(72 citation statements)

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“…It is possible to obtain polymeric structures sensitive to both temperature and pH, by the simple combination of ionisable and hydrophobic (inverse thermosensitive) functional groups. It has mainly been achieved by the copolymerization of monomers bearing these functional groups,190, 191 combining thermosensitive polymers with polyelectrolytes (SIPN, IPN)192 or by the development of new monomers that respond simultaneously to both stimuli 193. Leung et al194 prepared smart core/shell microgels based on PNIPAAm, MBAAm and chitosan or poly(ethyleneimine) in the absence of surfactants.…”

Section: Advancements In Polymer Systems For Cell Culturementioning

confidence: 99%

Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications

Ravichandran

Sundarrajan

Venugopal

et al. 2012

Macromolecular Bioscience

173

105

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The characteristics of tissue engineered scaffolds are major concerns in the quest to fabricate ideal scaffolds for tissue engineering applications. The polymer scaffolds employed for tissue engineering applications should possess multifunctional properties such as biocompatibility, biodegradability and favorable mechanical properties as it comes in direct contact with the body fluids in vivo. Additionally, the polymer system should also possess biomimetic architecture and should support stem cell adhesion, proliferation and differentiation. As the progress in polymer technology continues, polymeric biomaterials have taken characteristics more closely related to that desired for tissue engineering and clinical needs. Stimuli responsive polymers also termed as smart biomaterials respond to stimuli such as pH, temperature, enzyme, antigen, glucose and electrical stimuli that are inherently present in living systems. This review highlights the exciting advancements in these polymeric systems that relate to biological and tissue engineering applications. Additionally, several aspects of technology namely scaffold fabrication methods and surface modifications to confer biological functionality to the polymers have also been discussed. The ultimate objective is to emphasize on these underutilized adaptive behaviors of the polymers so that novel applications and new generations of smart polymeric materials can be realized for biomedical and tissue engineering applications.

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Section: Advancements In Polymer Systems For Cell Culturementioning

confidence: 99%

Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications

Ravichandran

Sundarrajan

Venugopal

et al. 2012

Macromolecular Bioscience

173

105

View full text Add to dashboard Cite

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“…All definitions focused on the change in the physical properties of material with response to their surrounding environment [1]- [7]. On the basis of their response, they are pH, temperature, light, electrical or ionic strength [8]- [14]. The occurrence of such materials has been found in many natural products, like leaves of Mimosa pudica and Venus flytrap [15].…”

Section: Introductionmentioning

confidence: 99%

Poly (N-Isopropyl Acrylamide-<i>Co</i>-Vanillin Acrylate) Dual Responsive Functional Copolymers for Grafting Biomolecules by Schiff’s Base Click Reaction

Abdelaty¹,

Kuckling²

2018

OJOPM

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This article reports on the synthesis of acrylate monomer from renewable material. Vanillin was selected to be the start material to produce new monomer called vanillin acrylate and abbreviated by (VA). It has been successfully investigated by 1 H, 13 C NMR, IR and UV and all results were in logic state. The next step was to synthetize three different thermo-responsive functional copolymers by incorporation of three different molar ratios of vanillin acrylate (10, 20, 30 mol%) with N-Isopropylacrylamide via free radical polymerization by AIBN as initiator in solution. All copolymers were deduced by 1 NMR and IR and all showed the presence of aldehyde group. The copolymer was used for grafting of tryptophan and ß-alanine through the chemical link between amino group and the active aldehyde group by click reactions to form Schiff's base imine compounds. Moreover, polymers were also elucidated by 1 HNMR, IR and UV, Size Exclusion Chromatography (SEC) was used for the molecular weight determination, differential scanning calorimeter (DSC) for glass temperature of solid polymers, XRD for crystallinity. UV-vis Spectroscopy was used for the determination of phase separation or the lower critical solution temperature (T c) of polymers solution not only in deionized water but in pH5 and pH11. The mount of conversation and linked amino acid was determined by UV-vis Spectroscopy.

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“…13 These all take advantage of the thermosensitive characteristics of PNIPAm. To obtain additional functionality, polyelectrolytes have been fabricated as a copolymer with PNIPAm so as to yield thermosensitive and pHsensitive polymers, using alginate, 14 varying amounts of acrylamide derivatives bearing carboxylic groups, 15 propylacrylic acid 16 and acrylic acid. 17 The chain-end structure 18 and hydrogel structure 19,20 have also been modified for PNIPAm.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a thermosensitive polycation by random copolymerization of N-vinylformamide and N-vinylbutyramide

Tachaboonyakiat

Ajiro

Akashi

2013

Polym J

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The novel thermoresponsive polycations poly(N-vinylbutyramide-co-vinylamide) (poly(NVBA-co-VAm)), with different mole ratios of poly(VAm) (PVAm):poly(NVBA) (PNVBA), were synthesized as a biomaterial by free radical copolymerization of poly (N-vinylbutyramide-coN -vinylformamide) (poly(NVBA-co-NVF), followed by acid hydrolysis. Such poly(N-vinylamide)s do not generate toxic low-molecular-weight amine compounds by hydrolysis, although the poly(acrylamide) structural isomers do. The mole ratio of PVAm and PNVBA was varied by adjusting the NVF:NVBA mol% feeding ratio used in the copolymerization. The lower critical solution temperature (LCST) of the obtained copolymers was investigated and compared with that of PNVBA. PNVBA showed an LCST of 32 1C, while that for poly(NVBA-co-VAm) increased as the VAm mole ratio increased (due to the increasing hydrophilicity), and the more physiologically relevant temperature (for humans) of 36.5 1C was obtained at a VAm mole ratio of 5%. Furthermore, the LCST of these copolymers not only depended on the VAm mole ratios but also on the pH, the concentration of the copolymer solution and ionic strength. Variation in the copolymer LCST could lead to several applications, especially for copolymers with an LCST value around physiological temperature that would potentially be of merit for a controlled drug or biomolecule delivery system.

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Temperature and pH dependent solubility of novel poly(N-isopropylacrylamide)-copolymers

Cited by 51 publications

References 0 publications

Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications

Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications

Poly (N-Isopropyl Acrylamide-<i>Co</i>-Vanillin Acrylate) Dual Responsive Functional Copolymers for Grafting Biomolecules by Schiff’s Base Click Reaction

Synthesis of a thermosensitive polycation by random copolymerization of N-vinylformamide and N-vinylbutyramide

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Temperature and pH dependent solubility of novel poly(N-isopropylacrylamide)-copolymers

Cited by 51 publications

References 0 publications

Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications

Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications

Poly (N-Isopropyl Acrylamide-&lt;i&gt;Co&lt;/i&gt;-Vanillin Acrylate) Dual Responsive Functional Copolymers for Grafting Biomolecules by Schiff’s Base Click Reaction

Synthesis of a thermosensitive polycation by random copolymerization of N-vinylformamide and N-vinylbutyramide

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Product

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About

Poly (N-Isopropyl Acrylamide-<i>Co</i>-Vanillin Acrylate) Dual Responsive Functional Copolymers for Grafting Biomolecules by Schiff’s Base Click Reaction