Temperature and H2O2-operated nano-valves on mesoporous silica nanoparticles for controlled drug release and kinetics

Guo, Feng; Li, Guiying; Zhou, Hengquan; Ma, Shenggui; Guo, Lei; Liu, Xunyong

doi:10.1016/j.colsurfb.2019.110643

Cited by 30 publications

(21 citation statements)

References 42 publications

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“…The enhanced rate of release was reported with increasing temperature or adding H2O2. 205 Crosslinking of the β-cyclodextrin functionalized chitosan (CD-CS) with disulfide bond implanted crosslinker (Ad-SSAd) febricated pH/reduction dual stimuli responsive supramolecular nanogel.…”

Section: Multistimuli Responsivenessmentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

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Hydrogels are three-dimensional, hydrophilic, polymeric frameworks, constructed through diverse physical or chemical crosslinks. Recent research focuses on their physiological stimuli sensitivity enhancing bioapplications. Biopolymers with responsiveness to local environment like temperature, pH etc. form the foundation in this regard, around which all major natural processes are circulated. Polysaccharides, being most the abundant biopolymers and essential constituent of our daily food like cereals and fruits, are readily available in nature. Hence, among numerous biomacromolecules, polysaccharides are extensively used to prepare hydrogel recently. However, incorporation of certain properties to these gels through derivatization can trigger stimuli responsiveness suitable for various applications especially in biomedical field inspired from the mother nature. For example, in situ cross-linking ability may deliver an intermediate platform between solid scaffolds and saline injections through reversible or irreversible sol-gel transition. Easy injectability provides patient’s relief through reducing recovery time and inflectional hazards. Self recovery of gel within body results automatic inflammation and damage recovery of tissues. This review provides a detail impression on the synthesis of natural polysaccharide derived hydrogel network with structural classification to bulk, supramolecular, micro and nano gel. Several properties important from biomedical point such as in situ, injectable, self healing nature of these hydrogels and various physical, chemical, or biochemical stimuli-responsive characteristics are discussed further. Lastly, their major bioapplications are highlighted.

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Section: Multistimuli Responsivenessmentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

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“…The standard calibration was repeated 3 times, and the R 2 of the standard curve were all more than 0.99. The drug-loading content (DLC%) and entrapment efficiency (EE%) of the nanogels were calculated according to the reference [27].…”

Section: Drug Loadingmentioning

confidence: 99%

Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery

et al. 2021

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Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and uniformity of the multiple-crosslinked nanogels. The multiple-crosslinked nanogels with the smallest size and the best uniformity was selected for the drug delivery. The drug-loading content and encapsulation efficiency were up to 35.01 and 66.82%, respectively. Their release behaviours are correlated with the pH value and the drug dosage. In general, the lower pH value and the lower drug dosage promoted the drug release. With the assistance of several kinetic models, it is found that drug diffusion plays a preponderant role in drug release, while polymer relaxation has a subtle effect. The multiple-crosslink resulting from ionic compounds and enzymes may provide a new perspective on developing novel biocompatible materials.

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“…Temperature and H2O2 dual-responsive nano-valves ZHUH SUHSDUHG IURP ȕ-cyclodextrin-poly(N-LVRSURS\ODFU\ODPLGH ȕ-CD-PNIPAM)-ferrocene nanovalves modified MSNs (MSN-Fc) [36]. Ferrocene (Fc) has a sandwiched structure and high biocompatibility and in the presence of H2O2 it gets LQVHUWHG WR ȕ-CD.…”

Section: Multiple Stimuli Responsive CD Based Materialsmentioning

confidence: 99%

Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review

et al. 2021

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In this review we discuss about the research advances in multiple stimuli responsive cyclodextrin (CD) based smart materials. CD based systems which are responsive to temperature, pH, enzymes, light, redox etc. along with various applications of these systems in the biomedical area are extensively covered. Current challenges and future perspectives of these smart stimuli-responsive drug delivery systems are also discussed.

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Temperature and H2O2-operated nano-valves on mesoporous silica nanoparticles for controlled drug release and kinetics

Cited by 30 publications

References 42 publications

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery

Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review

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