Temperature alters the hypothalamic transcription of photoperiod responsive genes in induction of seasonal response in migratory redheaded buntings

Trivedi, Amit Kumar; Sur, Sayantan; Sharma, Aakansha; Taufique, S. K. Tahajjul; Gupta, Neelu; Kumar, Vinod

doi:10.1016/j.mce.2019.110454

Cited by 36 publications

(23 citation statements)

References 73 publications

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“…In this study, EYA3 was expressed in all eight tissues in rams, which implies that it plays a role in promoting the differentiation of many tissues. This is in agreement with EYA3 being widely expressed in the pituitary, pineal gland, cerebrum, cerebellum, hypothalamus, fallopian tube, ovary, adrenal gland and kidney in seasonal estrous and year-round estrous ewes (Xia et al, 2018). The highest expression of EYA3 in testis in STH ram indicated that EYA3 is associated with the testis function.…”

Section: Eya3 Expression In Seasonally Estrous Andsupporting

confidence: 86%

Expression analysis of DIO2, EYA3, KISS1 and GPR54 genes in year-round estrous and seasonally estrous rams

Xia

et al. 2020

Arch. Anim. Breed.

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Abstract. The expression characteristics of the hypothalamic–pituitary–gonadal (HPG) axis-related candidate genes, DIO2, EYA3, KISS1 and GPR54, were analyzed in year-round estrous rams (small-tail Han sheep, STH) and seasonally estrous rams (Sunite sheep, SNT) using qPCR. The results were as follows: DIO2 was mainly expressed in pituitary, and KISS1 was specifically expressed in hypothalamus in the two groups. However, EYA3 and GPR54 were widely expressed in the cerebrum, cerebellum, hypothalamus, pituitary, testis, epididymis, vas deferens and adrenal gland tissues in both breeds, with significant differences in the cerebellum, hypothalamus, pituitary, testis and vas deferens tissues. We speculated that DIO2 and KISS1 may have positive roles in different regions in ram year-round estrus. Moreover, the expression patterns of EYA3 and GPR54 suggested that they may regulate the estrous mode of ram via testis and vas deferens. This is the first study to systematically analyze the expression patterns of HPG axis-related genes in rams.

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Section: Eya3 Expression In Seasonally Estrous Andsupporting

confidence: 86%

Expression analysis of DIO2, EYA3, KISS1 and GPR54 genes in year-round estrous and seasonally estrous rams

Xia

et al. 2020

Arch. Anim. Breed.

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“…In temperate and tropical bird species, [20][21][22][23][24][25] the seasonal reproductive response depends on photoperiodic control of thyrotropin beta subunit (Tshb) expression in the PT and consequent thyrotropin-receptor-mediated changes in MBH function exemplified by changes in the expression of the thyroid hormone deiodinase genes, Dio2 and Dio3. Similarly, in the Svalbard ptarmigan, Tshb expression in the PT was continuously suppressed under SP, and transfer to LL strongly induced Tshb expression, which peaked 13 h after lights on, i.e., circadian time 13 (CT 13) (Figure 1E; p < 0.0001 compared to SP control birds by Sidak's multiple comparisons test after two-way ANOVA; all test details can be found online (https://doi.org/10.18710/LUAHFK), before falling back to SP levels 23 h after lights on (CT 23).…”

Section: In Briefmentioning

confidence: 99%

Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird

et al. 2021

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“…In both sheep and mouse, EYA3 and its partner SIX1 synergistically act as upstream inducers of the TSHB transcription to induce the expression of TSHB ( 8 , 19 ). Furthermore, TSHB acts locally on TSHR -expressing cells in the adjacent basal hypothalamus, leading to altered expression of DIO2 ( 5 , 6 , 47 ). Then, DIO2 can regulate the secretion of TH in the basal hypothalamus and further modulate the transition of reproductive status through the spatial structure of GnRH neurons ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of Photoperiod-Induced LncRNAs and mRNAs in Pituitary Pars Tuberalis of Sheep

Xia

Chu

et al. 2021

Front. Vet. Sci.

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The pituitary pars tuberalis (PT) is the regulating center of seasonal reproduction, which can sense the melatonin signal and eventually cause downstream changes of GnRH secretion through TSHβ. Recently, lncRNAs have been identified in animal reproductive-related tissues, and they play important roles in reproductive regulation. Therefore, in this study, we expect to identify photoperiod-induced lncRNAs and genes in pituitary PT of sheep by comparison of expression profiles between short photoperiod (SP) and long photoperiod (LP). Through RNA-Seq, a total of 55,472 lncRNAs were identified in pituitary PT of Sunite ewes. The number of differentially expressed (DE) genes and lncRNAs between SP and LP increased gradually with the extension of LP (from LP7 to LP42). The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2, and EZH2, and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3, and TH. In enriched pathways for DE genes and lncRNA target genes between SP and LP, the reproduction- and circadian-related pathways were highlighted. In addition, the interactome analysis of lncRNAs and their targets implied that MSTRG.209166 and its trans-target TSHB, MSTRG.288068 and its cis-target SIX1, and ENSOARG00000026131 and its cis-target TH might participate in regulation of seasonal reproduction. Together, these results will help to determine important photoperiod-induced lncRNAs and genes and give us some new insights into the epigenetic regulation of seasonal reproduction in sheep.

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Temperature alters the hypothalamic transcription of photoperiod responsive genes in induction of seasonal response in migratory redheaded buntings

Cited by 36 publications

References 73 publications

Expression analysis of <i>DIO2</i>, <i>EYA3</i>, <i>KISS1</i> and <i>GPR54</i> genes in year-round estrous and seasonally estrous rams

Expression analysis of <i>DIO2</i>, <i>EYA3</i>, <i>KISS1</i> and <i>GPR54</i> genes in year-round estrous and seasonally estrous rams

Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird

Identification of Photoperiod-Induced LncRNAs and mRNAs in Pituitary Pars Tuberalis of Sheep

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Temperature alters the hypothalamic transcription of photoperiod responsive genes in induction of seasonal response in migratory redheaded buntings

Cited by 36 publications

References 73 publications

Expression analysis of &lt;i&gt;DIO2&lt;/i&gt;, &lt;i&gt;EYA3&lt;/i&gt;, &lt;i&gt;KISS1&lt;/i&gt; and &lt;i&gt;GPR54&lt;/i&gt; genes in year-round estrous and seasonally estrous rams

Expression analysis of &lt;i&gt;DIO2&lt;/i&gt;, &lt;i&gt;EYA3&lt;/i&gt;, &lt;i&gt;KISS1&lt;/i&gt; and &lt;i&gt;GPR54&lt;/i&gt; genes in year-round estrous and seasonally estrous rams

Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird

Identification of Photoperiod-Induced LncRNAs and mRNAs in Pituitary Pars Tuberalis of Sheep

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Expression analysis of <i>DIO2</i>, <i>EYA3</i>, <i>KISS1</i> and <i>GPR54</i> genes in year-round estrous and seasonally estrous rams

Expression analysis of <i>DIO2</i>, <i>EYA3</i>, <i>KISS1</i> and <i>GPR54</i> genes in year-round estrous and seasonally estrous rams