Temozolomide‐induced flare in high‐grade gliomas: a new clinical entity

Rosenthal, MA; Ashley, David M.; Cher, Lawrence

doi:10.1046/j.1445-5994.2002.00242.x

Cited by 14 publications

(11 citation statements)

References 7 publications

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“…Chao et al reported that 18 F-FDG was 75% sensitive and 81% specific in differentiating recurrence from RN. 27 Two studies compared the use of 18 F-FDG and 11 carbon-methionine ( 11 C-MET) and concluded that Table 1 Characteristics of pseudoprogression (PP), recurrence and necrosis (RN) in patients with high-grade glioma [2][3][4][5][6][7][8][9][10] Time after treatment PP Recurrence RN 2-3 mo 2 mo to 5 yrs 3 mo to 20 yrs 123 I-IMT = 123 iodine-alpha-methyl-tyrosine, 201 Tl = 201 thallium, 99m Tc-GHA = 99m technetium-glucoheptonate acid, 99m Tc-MIBI = 99m Tc-hexakis-2-methoxyisobutylisonitrile, Accy = accuracy, HGG = high-grade glioma, NPV = negative predictive value, P = prospective, PPV = positive predictive value, R = retrospective, Sn = sensitivity, Sp = specificity, SPECT = single photon emission CT. * Path = total number of patients with pathological confirmation. both radiotracers were more sensitive (95% and 75%) than specific (50% and 70%) in detecting recurrence.…”

Section: Petmentioning

confidence: 99%

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Imaging modalities in high-grade gliomas: Pseudoprogression, recurrence, or necrosis?

Caroline

Rosenthal

2012

Journal of Clinical Neuroscience

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Section: Petmentioning

confidence: 99%

“…2 It is believed that PP is due to cytotoxic effects of chemotherapy and radiation. 3 PP usually occurs within two to three months of treatment and, in particular, appears more frequent following concurrent chemotherapy and radiotherapy. PP lesions may decrease in size or stabilise without intervention.…”

Section: Introductionmentioning

confidence: 99%

Imaging modalities in high-grade gliomas: Pseudoprogression, recurrence, or necrosis?

Caroline

Rosenthal

2012

Journal of Clinical Neuroscience

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“…[193][194][195][196][197] For non-haematological AEs, a syndrome of TMZinduced neurological 'flare' has been described by Rosenthal and co-workers. 198 They report eight patients (at least 2% of those receiving TMZ in their unit) experiencing a sudden and unexpected deterioration in neurological status within a few days of commencing TMZ. Symptoms included weakness, dysphagia, headache, confusion and convulsions.…”

Section: Case Reportsmentioning

confidence: 99%

The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation

Garside¹,

Pitt²,

Anderson³

et al. 2007

Health Technol Assess

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“…This may represent a flare response as previously reported by our group. 18 There are two obvious limitations with this study. First, radiological assessment of response in glioma treatment is recognised as complex and fraught with error.…”

Section: Discussionmentioning

confidence: 95%