Temoporfin mediated photodynamic therapy in patients with local persistent and recurrent nasopharyngeal carcinoma after curative radiotherapy: A feasibility study

Nyst, Heike J.; Wildeman, Maarten A.; Indrasari, Sagung Rai; Karakullukçu, Barış; Veen, R.L.P. van; Adham, Marlinda; Stewart, Fiona; Levendag, Peter C.; Sterenborg, Henricus J. C. M.; Tan, I. Bing

doi:10.1016/j.pdpdt.2012.07.002

Cited by 24 publications

(20 citation statements)

References 28 publications

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“…Nyst et al [17•] treated 22 patients with temoporfin (second-generation photosensitizer) mediated PDT in Indonesia. They did not make a distinction in therapy response between residual and recurrent disease, but only one patient had recurrent disease.…”

Section: Treatmentmentioning

confidence: 99%

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Current Treatment Options for Local Residual Nasopharyngeal Carcinoma

Stoker

Diessen

Boer

et al. 2013

Curr. Treat. Options in Oncol.

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Opinion statementLocal residual disease occurs in 7-13 % after primary treatment for nasopharyngeal carcinoma (NPC). To prevent tumor progression and/or distant metastasis, treatment is indicated. Biopsy is the “gold standard” for diagnosing residual disease. Because late histological regression frequently is seen after primary treatment for NPC, biopsy should be performed when imaging or endoscopy is suspicious at 10 weeks. Different modalities can be used in the treatment of local residual disease. Interestingly, the treatment of residual disease has better outcomes than treatment of recurrent disease. For early-stage disease (rT1-2), treatment results and survival rates are very good and comparable to patients who had a complete response after the first treatment. Surgery (endoscopic or open), brachytherapy (interstitial or intracavitary), external or stereotactic beam radiotherapy, or photodynamic therapy all have very good and comparable response rates. Choice should depend on the extension of disease, feasibility of the treatment, and doctor’s and patient’s preferences and experience, as well as the risks of the adverse events. For the more extended tumors, choice of treatment is more difficult, because complete response rates are poorer and severe side effects are not uncommon. The results of external beam reirradiation and stereotactic radiotherapy are better than brachytherapy for T3-4 tumors. Photodynamic therapy resulted in good palliative responses in a few patients with extensive disease. Also, chemotherapeutics or the Epstein-Barr virus targeted therapies can be used when curative intent treatment is not feasible anymore. However, their advantage in isolated local failure has not been well described yet. Because residual disease often is a problem in countries with a high incidence of NPC and limited radiotherapeutic and surgical facilities, it should be understood that most of the above mentioned therapeutic modalities (radiotherapy and surgery) will not be readily available. More research with controlled, randomized trials are needed to find realistic treatment options for residual disease.

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Section: Treatmentmentioning

confidence: 99%

“…We would like to emphasize the need to study residual disease, because we believe, based on our experience in Indonesia, that residual disease is an underexposed problem [16••, 17•]. The reason for the good results of residual disease compared with recurrent might be derived from insufficient primary treatment.…”

Section: Introductionmentioning

confidence: 99%

Current Treatment Options for Local Residual Nasopharyngeal Carcinoma

Stoker

Diessen

Boer

et al. 2013

Curr. Treat. Options in Oncol.

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“…Lofgren et al [18] treated five patients with a tumour depth <10 mm; 3 out of 5 patients remained local disease free for over 4 years [18]. In 2012, we published the results of 22 patients treated for tumours with a depth <10 mm; 17 (77%) were available for evaluation with biopsy, all had a complete response, and the 3 year overall survival was >50% (20). Recently, Succo et al [21] published the results of six NPC patients with small local disease (T1 or T2a (AJCC, 2007)), five (83%) had a complete response.…”

Section: Discussionmentioning

confidence: 99%

“…After the treatment the applicator was removed. The procedure is described more in detail in previous publications of our group [13,20].…”

Section: Treatmentmentioning

confidence: 99%

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Photodynamic therapy as salvage therapy for patients with nasopharyngeal carcinoma experiencing local failures following definitive radiotherapy

Stoker

Indrasari

Herdini

et al. 2015

Photodiagnosis and Photodynamic Therapy

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Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

Volgger

Betz

2016

Journal of Biophotonics

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The gold standard in the treatment of (pre)malignancies of the upper aerodigestive tract (UADT) is either surgery or (chemo)radiotherapy. Nevertheless, there are special indications where an alternative treatment, such as photodynamic therapy (PDT), might be as effective for and better tolerated by the patients concerned. This article aims to present a contemporary and comprehensive review on the role of photodynamic therapy in the treatment of (pre)malignancies of the UADT. PubMed was searched for "photodynamic therapy larynx/oral cavity/oropharynx/head and neck" in 01/2016. PDT can be efficient in the treatment of recurrent, residual or multiple carcinomas of the UADT without other treatment options. It has also been used with success in the treatment of early oral or laryngeal carcinomas, widespread precancerous lesions or "difficult-to-treat" skin cancer, even though these treatments are off-label. For now, unsolved scientific and economical challenges hinder the methods spread. In special cases, PDT is a highly effective method to treat head and neck (pre)malignancies. Nevertheless, further clinical studies are needed to better define its true value in head and neck oncology.

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Temoporfin mediated photodynamic therapy in patients with local persistent and recurrent nasopharyngeal carcinoma after curative radiotherapy: A feasibility study

Cited by 24 publications

References 28 publications

Current Treatment Options for Local Residual Nasopharyngeal Carcinoma

Current Treatment Options for Local Residual Nasopharyngeal Carcinoma

Photodynamic therapy as salvage therapy for patients with nasopharyngeal carcinoma experiencing local failures following definitive radiotherapy

Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

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