1991
DOI: 10.1002/jor.1100090617
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Telopeptide‐depleted bovine skin collagen as a carrier for bone morphogenetic protein

Abstract: The telopeptide of type I collagen is thought to be responsible for causing immunogenic response when introduced into xenogenic hosts. To eliminate this problem, solubilized bovine skin collagen was filtered through a millipore membrane, digested repeatedly with pepsin to remove telopeptides, and used as a carrier for a water-soluble, partially-purified fraction of bone morphogenetic protein (BMP) in mice. Composite implants of this telopeptide-depleted collagen and the partially-purified BMP fraction consiste… Show more

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Cited by 130 publications
(60 citation statements)
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“…Osteoconductive delivery systems have included collagenous materials, such as type I collagen (as sponges, gels, or fibrils) [19,[26][27][28][29][30], and type IV collagen [31,32]; inorganic ceramic materials, such as hydroxyapatite (HA) (as a powder, granules, or blocks) [33,34], tricalcium phosphate (TCP) [35], glass ceramic, and other inorganic materials; cartilage-or bone-derived materials, such as coral, chitin, and bone mineral,; and composites of different types of these materials [20]. BMP have also been used in combination with titanium and other metal alloys [36].…”
Section: Delivery Systems For Bmpmentioning
confidence: 99%
“…Osteoconductive delivery systems have included collagenous materials, such as type I collagen (as sponges, gels, or fibrils) [19,[26][27][28][29][30], and type IV collagen [31,32]; inorganic ceramic materials, such as hydroxyapatite (HA) (as a powder, granules, or blocks) [33,34], tricalcium phosphate (TCP) [35], glass ceramic, and other inorganic materials; cartilage-or bone-derived materials, such as coral, chitin, and bone mineral,; and composites of different types of these materials [20]. BMP have also been used in combination with titanium and other metal alloys [36].…”
Section: Delivery Systems For Bmpmentioning
confidence: 99%
“…To explore the mechanism for BMP-induced bone formation, we developed an in vivo experimental model system for the local delivery of recombinant human BMP-2 (rhBMP-2) impregnated in pepsin-digested Type I collagen [29]. With this model we can reproducibly induce ectopic bone and assess bone formation quantitatively in any wildtype or transgenic mice [17,34].…”
Section: Introductionmentioning
confidence: 99%
“…Bone morphogenetic protein1-3), which is a bioactive factor, has been traditionally used to induce bone reconstruction in conjunction with various biomaterials [4][5][6][7] .…”
Section: Introductionmentioning
confidence: 99%