Telomeric repeat‐containing <scp>RNA</scp> (<scp>TERRA</scp>) related to polycystic ovary syndrome (<scp>PCOS</scp>)

Wang, Caiqin; Shen, Fengxian; Zhu, Yangjun; Fang, Yuying; Lü, Shiming

doi:10.1111/cen.13283

Cited by 26 publications

(18 citation statements)

References 36 publications

(60 reference statements)

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“…Of the 7 studies reviewed, 3 studies showed a negative association between LTL and PCOS patients (35-37) while Wei et al demonstrated significantly longer GTL but a negative association between LTL and PCOS patients (56). Further, 1 study revealed significantly longer LTL in patients with PCOS (57). Contrastingly, Li et al demonstrated that LTL was shorter in women with PCOS and that a short LTL increased the risk of disease (58).…”

Section: Telomere Length and Female Infertilitymentioning

confidence: 89%

The association of female and male infertility with telomere length (Review)

et al. 2019

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Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negative association between relative TL and different factors of female and male infertility. A systematic search of the PubMed database was conducted. Out of the 206 studies identified, 45 were reviewed as they fulfilled the criteria of validity and relevance. Following an analysis and a comparison of the study outcomes, several clear trends were observed. The majority of female infertility factors were associated with a shorter TL, with the exception of endometriosis, premature ovarian failure and clear cell carcinoma that were associated with a longer TL and polycystic ovary syndrome (PCOS), which revealed conflicting results among several studies, leading to ambiguous conclusions. Male infertility factors were associated with a shorter TL. Although this review can provide an outline of general trends in the association of TL with infertility factors, further epidemiological and original research studies are required to focus on investigating the basis of these varying lengths of telomeres. Contents 1. Introduction 2. Telomere length and female infertility 3. Telomere length and male infertility 4. Conclusions and future perspectives

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Section: Telomere Length and Female Infertilitymentioning

confidence: 89%

The association of female and male infertility with telomere length (Review)

et al. 2019

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“…The decrease in estrogen levels in postmenopausal females compared to premenopause may prevent activation of telomerase to catalyze the synthesis and extension of telomeres[39]. For the relationship between LTL and testosterone, one previous study performed by Wang et al, reported LTL were positively associated with polycystic ovary syndrome(PCOS) and indicated higher testosterone expression could promote telomere lengthening[42]. In a prospective clinical study, patients with short telomeres had an increase in telomere length in response to a pharmacologic intervention with male hormone[43].…”

Section: Discussionmentioning

confidence: 99%

Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length

et al. 2017

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The mechanism of cellular aging likely involves decreased telomere length and is associated with age-related diseases such as cardiovascular disease. Metabolic syndrome (MetS) is an important risk factor for CVD. The purpose of this study was to investigate the association between LTL and MetS. We evaluated 7370 participants in the National Health and Nutrition Examination Survey (1999–2002). The association between LTL and individual MetS components and the number of MetS components was analyzed by multivariable regression models, adjusting for gender, race/ethnicity, albumin, C-reactive protein, alanine transaminase, uric acid and medical condition. An increase in the number of MetS components was strongly associated with shorter telomere length, especially in female participants (p for trend < 0.05). In addition, triglycerides were negatively associated with LTL in female participants (p < 0.001). Waist circumstance was associated with decreased LTL (p < 0.05) in both males and females. In summary, our study indicated that an increment of MetS component is strongly associated with shorter LTL, especially in the female population.

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“…(2017) also analyzed telomere length and TERRA levels in peripheral blood leukocytes of patients with PCOS and control subjects [96] and found that the telomeres were significantly longer in the patient-derived leukocytes [96]. Of note, the level of TERRAs, contributing to the regulation of telomere length, was found to be lower in the PCOS patients [96]. Previous studies have shown that, after aromatization, androgens may regulate telomerase expression and activity, acting through ERα [97, 98].…”

Section: Ovarian Function and Telomeres/telomerase Activity In Humansmentioning

confidence: 99%

Telomere length and telomerase activity during folliculogenesis in mammals

Kosebent

Uysal

Öztürk

2018

Journal of Reproduction and Development

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Telomeres are repetitive non-coding DNA sequences located at the ends of chromosomes in eukaryotic cells. Their most important function is to protect chromosome ends from being recognized as DNA damage. They are also implicated in meiosis and synapse formation. The length of telomeres inevitably shortens at the end of each round of DNA replication and, also, as a consequence of the exposure to oxidative stress and/or genotoxic agents. The enzyme telomerase contributes to telomere lengthening. It has been reported that telomerase is exclusively expressed in germ cells, granulosa cells, early embryos, stem cells, and various types of cancerous cells. Granulosa cells undergo many mitotic divisions and either granulosa cells or oocytes are exposed to a variety of genotoxic agents throughout folliculogenesis; thus, telomerase plays an important role in the maintenance of telomere length. In this review article, we have comprehensively evaluated the studies focusing on the regulation of telomerase expression and activity, as well as telomere length, during folliculogenesis from primordial to antral follicles, in several mammalian species including mice, bovines, and humans. Also, the possible relationships between female infertility caused by follicular development defects and alterations in the telomeres and/or telomerase activity are discussed.

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Telomeric repeat‐containing RNA (TERRA) related to polycystic ovary syndrome (PCOS)

Abstract: We found TERRA expression in human peripheral blood leucocytes, and LTLs were positively associated with PCOS. TERRA and testosterone play an important role in the LTL regulation in PCOS.

Cited by 26 publications

References 36 publications

The association of female and male infertility with telomere length (Review)

The association of female and male infertility with telomere length (Review)

Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length

Telomere length and telomerase activity during folliculogenesis in mammals

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