Telomeres shorten more slowly in long-lived birds and mammals than in short–lived ones

Haussmann, Mark F.; Winkler, David W.; O’Reilly, Kathleen; Huntington, Charles E.; Nisbet, Ian C. T.; Vleck, Carol M.

doi:10.1098/rspb.2003.2385

Cited by 248 publications

(300 citation statements)

References 48 publications

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“…Another concept critical to the interpretation of the data in this study is that relationships between BER (or other DNA repair activities) and lifespan may be highly cell-type specific. Previously, various authors have described positive correlations between species' MLSP and poly(ADP-ribose) polymerase activity (Grube and Bürkle 1992), NER (Cortopassi and Wang 1996), double-strand break recognition (Lorenzini et al 2009), and telomere length maintenance (Haussmann et al 2003) in fibroblasts and blood cells. These cell types will have very different characteristics than those Table 1) and NP=no nuclear protein extract.…”

Section: Discussionmentioning

confidence: 99%

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan

Page

Stuart

2011

AGE

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Accumulation of DNA lesions compromises replication and transcription and is thus toxic to cells. DNA repair deficiencies are generally associated with cellular replicative senescence and premature aging syndromes, suggesting that efficient DNA repair is required for normal longevity. It follows that the evolution of increasing lifespan amongst animal species should be associated with enhanced DNA repair capacities. Although UV damage repair has been shown to correlate positively with mammalian species lifespan, we lack similar insight into many other DNA repair pathways, including base excision repair (BER). DNA is continuously exposed to reactive oxygen species produced during aerobic metabolism, resulting in the occurrence of oxidative damage within DNA. Shortpatch BER plays an important role in repairing the resultant oxidative lesions. We therefore tested whether an enhancement of BER enzyme activities has occurred concomitantly with the evolution of increased maximum lifespan (MLSP). We collected brain and liver tissue from 15 vertebrate endotherm species ranging in MLSP over an order of magnitude. We measured apurinic/ apyrimidinic (AP) endonuclease activity, as well as the rates of nucleotide incorporation into an oligonucleotide containing a single nucleotide gap (catalyzed by BER polymerase β) and subsequent ligation of the oligonucleotide. None of these activities correlated positively with species MLSP. Rather, nucleotide incorporation and oligonucleotide ligation activities appeared to be primarily (and negatively) correlated with species body mass.

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Section: Discussionmentioning

confidence: 99%

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan

Page

Stuart

2011

AGE

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“…Recent studies in birds have examined telomere length as a potential biomarker of individual age, and in relation to interspecific variation in lifespan (Haussmann & Vleck 2002;Haussmann et al 2003a,b). Old birds display shorter blood cell telomeres in the domestic chicken (Gallus domesticus) (Venkatesan & Price 1998;Delany et al 2000), zebra finch (Taeniopygia guttata), tree swallow (Tachycineta bicolor), Adélie penguin (Pygoscelis adeliae) and common tern (Sterna hirundo) (Haussmann & Vleck 2002;Haussmann et al 2003b). As in most investigations of changes in telomere length with age, these avian studies are based on comparisons of telomere length among individuals of differing ages (cross-sectional analysis), because repeat measures of known-age individuals across a sufficient time span are very difficult to obtain, especially from long-lived organisms in the wild.…”

Section: Introductionmentioning

confidence: 99%

Telomere loss in relation to age and early environment in long-lived birds

Hall

Nasir

Daunt

et al. 2004

Proc. R. Soc. Lond. B

196

208

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Shortening of telomeres, specific nucleotide repeats that cap eukaryotic chromosomes, is thought to play an important role in cellular and organismal senescence. We examined telomere dynamics in two longlived seabirds, the European shag and the wandering albatross. Telomere length in blood cells declines between the chick stage and adulthood in both species. However, among adults, telomere length is not related to age. This is consistent with reports of most telomere loss occurring early in life in other vertebrates. Thus, caution must be used in estimating annual rates of telomere loss, as these are probably not constant with age. We also measured changes within individuals in the wild, using repeat samples taken from individual shags as chicks and adults. We found high inter-individual variation in the magnitude of telomere loss, much of which was explained by circumstances during growth. Individuals laying down high tissue mass for their size showed greater telomere shortening. Independently of this, individuals born late in the season showed more telomere loss. Early conditions, possibly through their effects on oxidative stress, appear to play an important role in telomere attrition and thus potentially in the longevity of individuals.

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“…Furthermore, telo meres did not shorten with age in Leach's storm-petrels, an extremely long-lived bird, but actually lengthened. This novel finding suggests that regulation of TL is associated not only with cellular replicative life span but also with organismal life span and that very long-lived organisms have escaped entirely any telomeric constraint on cellular replicative life span [50].…”

Section: Molecular Biologics Of Telomeredependent Senescencementioning

confidence: 80%

“…These findings may provide a mechanistic basis for epidemiological studies linking early growth retardation to adult degenerative diseases [49]. Another group of authors measured TL in erythrocytes from five bird species with markedly different life spans [50]. Species with shorter life spans lost more telomeric repeats with age than species with longer life spans.…”

Section: Molecular Biologics Of Telomeredependent Senescencementioning

confidence: 98%

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

Babizhayev¹,

Vishnyakova

Yegorov

2014

Journal of Basic and Clinical Physiology and Pharmacology

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It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, and telomere length (TL) may be an informative biomarker of healthy aging. Hormone-brain-aging behaviormodulated telomere dynamics and changes in telomerase activity are consistent elements of cellular alterations associated with changes in proliferative state, and these processes are consequently considered as the new therapeutic drug targets for physiological control with advanced drug delivery and nutritional formulations. We raise and support a therapeutic concept of using nonhydrolyzed forms of naturally occurring neuron-specific imidazole dipeptide-based compounds carnosine and carcinine, making it clinically possible that slowing down the rate of telomere shortening could slow down the human aging process in specific tissues where proliferative senescence is known to occur, with the demonstrated evidence of telomere shortening that appeared to be a hallmark of oxidative stress and disease. Carnosine released from skeletal muscle during exercise may be transported into the hypothalamic tuberomammillary nucleus (TMN) histamine neurons and hydrolyzed. The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and hormone-like antiaging physiological function. The preliminary longitudinal studies of elderly individuals suggest that longer telomeres are associated with better survival, and an advanced oral nutritional support with nonhydrolyzed carnosine (or carcinine and patented compositions thereof) is a useful therapeutic tool for a critical TL maintenance that may fundamentally be applied in the treatment of age-related sight-threatening eye disorders, prolonged life expectancy, increased survival and chronological age of an organism in health control, smoking behavior, and disease."Our pleasures were simple-they included survival." -Dwight D. Eisenhower, 34th President of the United States, 1953States, -1961

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Telomeres shorten more slowly in long-lived birds and mammals than in short–lived ones

Cited by 248 publications

References 48 publications

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan

Telomere loss in relation to age and early environment in long-lived birds

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

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