Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations

Bolzán, Alejandro D.; Bianchi, Martha S.

doi:10.1016/j.mrrev.2005.12.003

Cited by 141 publications

(175 citation statements)

References 299 publications

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“…Gels were UV cross-linked, denaturated, neutralized and transferred onto nylon membranes. Filters were hybridized in rapid hybridization buffer in the presence of a digoxigenin-labelled telomeric probe (TTAGGG) 4 . Telomere restriction fragments were detected by autoradiography and densitometric analysis.…”

Section: (A) Telomere Length Analysismentioning

confidence: 99%

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Nestling telomere length does not predict longevity, but covaries with adult body size in wild barn swallows

et al. 2013

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Telomere length and dynamics are increasingly scrutinized as ultimate determinants of performance, including age-dependent mortality and fecundity. Few studies have investigated longevity in relation to telomere length (TL) in the wild and none has analysed longevity in relation to TL soon after hatching, despite the fact that telomere shortening may mostly occur early in life. We show that TL in nestling barn swallows (Hirundo rustica) in the wild does not predict longevity. However, TL positively covaries with body size, suggesting that individuals with large TL can afford to grow larger without paying the cost of reduced TL, and/or that benign rearing conditions ensure both large body size and low rates of telomere shortening. Overall, our study hints at a role of TL in developmental processes, but also indicates a need for further analyses to assess the expectation that TL in young individuals predicts longevity in the wild.

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Section: (A) Telomere Length Analysismentioning

confidence: 99%

“…Telomeres accomplish multiple functions, including protection of chromosomes from loss of encoding parts caused by the 'end replication' problem, that is, failure of DNA polymerase to fully replicate linear DNA at its 3 0 end [4]. Telomere shortening can be countered by telomerase enzymatic action, which tends to elongate telomeres [5].…”

Section: Introductionmentioning

confidence: 99%

Nestling telomere length does not predict longevity, but covaries with adult body size in wild barn swallows

et al. 2013

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“…[63] Decades of subsequent studies have revealed this telomeric 'capping' function is related to a wide variety of telomere associated proteins, [64,65] attachment to the nuclear matrix, [66,67] and higher-order chromatin structures. [68][69][70] It should be noted that large differences in telomere length, [71] elongation mechanism(s), [6] and different telomeric end structures have been observed, [6,69] even in closely related species and cell types.…”

Section: Evidence For Telomeric G-quadruplex Dnamentioning

confidence: 99%

“…[41,63,72] These overhangs contain repetitive G-rich sequences such as (G 2-3 (TG) 1-6 T) n for Saccharomyces, (TG-GGGT) n for Tetrahymena, (TTTTGGGG) n for Stylonychia, (TTTAGGG) n for Arabidopsis, and (TTAGGG) n for vertebrates. In the late 1980s G-quadruplex structures derived from 3' telomeric overhangs were first reported.…”

Section: Evidence For Telomeric G-quadruplex Dnamentioning

confidence: 99%

Targeting G-Quadruplex DNA with Small Molecules

Luedtke¹

2009

Chimia

100

105

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Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered. Cell-permeable G-quadruplex specific probes should provide researchers with new tools for studying these alternately folded DNA structures and their potential involvement in gene expression, chromosome stability, viral integration, and recombination. In this review, a survey of the binding affinity, specificity, and biological/pharmacological activities of some well-characterized G-quadruplex ligands is presented along with the potential importance of G-quadruplex DNA in vivo.134 CHIMIA 2009, 63, No. 3 Young AcAdemics in switzerlAnd PArt ii doi:10.2533doi:10. /chimia.2009doi:10. .134 Chimia 63 (2009 Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered. Cell-permeable Gquadruplex specific probes should provide researchers with new tools for studying these alternately folded DNA structures and their potential involvement in gene expression, chromosome stability, viral integration, and recombination. In this review, a survey of the binding affinity, specificity, and biological/pharmacological activities of some well-characterized G-quadruplex ligands is presented along with the potential importance of G-quadruplex DNA in vivo.

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“…The telomere structure, consisting of DNA repeat sequences (5′-TTAGGG-3′), is highly conserved among vertebrates (Meyne et al, 1989) as well as among invertebrates (Traut et al, 2007). Cells approach senescence if telomere length reaches a certain threshold, the so-called Hayflick limit (Bolzán and Bianchi, 2006;Hayflick, 1965). The activation of the enzyme telomerase (Aubert and Lansdorp, 2008) or alternative telomere lengthening pathways (Bryan et al, 1997) can maintain telomere lengths, leading to theoretically unlimited proliferative potential.…”

Section: Introductionmentioning

confidence: 99%

Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica

Gruber

Schaible

Ridgway

et al. 2014

Experimental Gerontology

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The shortening of telomeres as a causative factor in ageing is a widely discussed hypothesis in ageing research. The study of telomere length and its regenerating enzyme telomerase in the longest-lived non-colonial animal on earth, Arctica islandica, should inform whether the maintenance of telomere length plays a role in reaching the extreme maximum lifespan (MLSP) of N500 years in this species. Since longitudinal measurements on living animals cannot be achieved, a cross-sectional analysis of a short-lived (MLSP 40 years from the Baltic Sea) and a long-lived population (MLSP 226 years Northeast of Iceland) and in different tissues of young and old animals from the Irish Sea was performed. A high heterogeneity of telomere length was observed in investigated A. islandica over a wide age range (10-36 years for the Baltic Sea, 11-194 years for Irish Sea, 6-226 years for Iceland). Constant telomerase activity and telomere lengths were detected at any age and in different tissues; neither correlated with age or population habitat. Stable telomere maintenance might contribute to the long lifespan of A. islandica. Telomere dynamics are no explanation for the distinct MLSPs of the examined populations and thus the cause of it remains to be investigated.

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Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations

Cited by 141 publications

References 299 publications

Nestling telomere length does not predict longevity, but covaries with adult body size in wild barn swallows

Nestling telomere length does not predict longevity, but covaries with adult body size in wild barn swallows

Targeting G-Quadruplex DNA with Small Molecules

Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica

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