Télomères et télomérase comme cibles thérapeutiques dans le traitement du cancer

Souiden, Yousra; Bouraoui, Abderrahman; Chaieb, Kamel; Mahdouani, Kacem

doi:10.1684/bdc.2010.1155

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…Telomerase is an enzyme responsible for telomere replication and is overexpressed in cancer cells but inactive in healthy cells [48]. In this regard, it has already been reported that HPV E6 and E7 persistently drive the expression of a catalytic unit in telomerase called hTERT, which gives these cells unlimited replicative capacity [49].…”

Section: Schematic Representation Of the Main Action Of E6 And E7 Vir...mentioning

confidence: 99%

Molecular and cell biology of cervical cancer

Garcia-Becerra,

A. Garcia-Becerra,

Fernandez-Avila

et al. 2023

Cervical Cancer - Recent Advances and New Perspectives

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The molecular and cell biology of cervical cancer will be covered in detail in this chapter, particularly emphasizing the disease’s etiology, brief epidemiology, risk factors, cervical cancer hallmarks, and the main signaling pathways involved. The chapter will go in-depth about the characteristics of cancer, such as changes in cell cycle regulation, apoptosis, and cell differentiation, as well as the tumoral microenvironment. Signal pathways like the PI3K/AKT/mTOR pathway and the Wnt/beta-catenin pathway will be highlighted for their significance in the development of cervical cancer. The chapter will thoroughly explain the molecular and cell biology underlying this terrible illness.

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Section: Schematic Representation Of the Main Action Of E6 And E7 Vir...mentioning

confidence: 99%

Molecular and cell biology of cervical cancer

Garcia-Becerra,

A. Garcia-Becerra,

Fernandez-Avila

et al. 2023

Cervical Cancer - Recent Advances and New Perspectives

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Biochemical Characterization of G4 Quadruplex Telomerase RNA Unwinding by the RNA Helicase RHAU

Booy

McRae

McKenna

2014

Methods in Molecular Biology

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G4 quadruplexes are stable secondary structures prevalent in DNA and RNA that exhibit diverse regulatory functions. Herein, we describe an in vitro technique using the purified RNA helicase RHAU to unwind a G4 quadruplex identified near the 5' end of the human telomerase RNA (hTR). A synthetic RNA corresponding to the quadruplex forming region of hTR (hTR10-43), as well as a predicted complementary strand (25P1), are combined in a reaction containing the purified helicase and ATP. Reaction products and appropriate controls are resolved by native gel electrophoresis. Gels can be stained using a combination of total RNA and quadruplex-specific dyes to observe the expected quadruplex to duplex conversion. This straightforward method can be extended to study structural changes in other inter- or intramolecular quadruplex containing DNA/RNA molecules with the RHAU helicase or other RNA/DNA remodeling enzymes.

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Télomères et télomérase comme cibles thérapeutiques dans le traitement du cancer

Cited by 2 publications

References 64 publications

Molecular and cell biology of cervical cancer

Molecular and cell biology of cervical cancer

Biochemical Characterization of G4 Quadruplex Telomerase RNA Unwinding by the RNA Helicase RHAU

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