volume 8, issue 2, P382-393 2016
DOI: 10.18632/aging.100904
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Birgit Linkus, Diana Wiesner, Martina Meßner, Alexander Karabatsiakis, Annika Scheffold, K. Lenhard Rudolph, Dietmar R. Thal, Jochen H. Weishaupt, Albert C. Ludolph, Karin M. Danzer

Abstract: Telomere shortening has been linked to a variety of neurodegenerative diseases. Recent evidence suggests that reduced telomerase expression results in shorter telomeres in leukocytes from sporadic patients with amyotrophic lateral sclerosis (ALS) compared with healthy controls. Here, we have characterized telomere length in microglia, astroglia and neurons in human post mortem brain tissue from ALS patients and healthy controls. Moreover, we studied the consequences of telomerase deletion in a genetic mouse mo…

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